Paper  doi  abstract   bibtex   

@article{lindeus_educational_2020,
	title = {Educational inequalities in fracture-related mortality using multiple cause of death data in the {Skåne} region, {Sweden}},
	volume = {48},
	issn = {1651-1905},
	url = {https://doi.org/10.1177/1403494818807831},
	doi = {10.1177/1403494818807831},
	abstract = {Aim: To assess the absolute and relative educational inequalities in mortality from hip and non-hip fractures in Skåne region, Sweden. Methods: We conducted a population-based open cohort study. People aged 30-99 years, resident in the region during 1998-2013 (n = 999, 148) were followed until death, their 100th birthday, relocation outside Skåne, or the end of 2014. We obtained individual-level data from the Statistics Sweden and the Swedish National Board of Health and Welfare's Cause of Death Register. Death certificates coded with any fracture diagnosis were defined as fracture-related deaths. Educational inequalities were assessed by slope and relative indices of inequality (SII and RII). Cox regression and additive hazard models were used to estimates these indices. Results: During a mean follow-up of 12.2 years, there were 5,121 fracture-related deaths, of which 3,110 were associated with hip fracture. Age-standardized, hip fracture-related mortality rates per 100,000 person-years were 31, 95\% confidence interval (CI) (30, 32) and 23 (20, 26) in people with low and high levels of education, respectively (rate ratio 1.4, 95\% CI (1.2, 1.5)). Corresponding mortality rates for non-hip-fracture related deaths were 20 (18, 21) and 16 (14, 19) (rate ratio 1.2, 95\% CI (1.0, 1.4)). SII and RII revealed educational inequalities in hip fracture-related mortality in favour of highly educated people. For non hip fracture-related mortality, there were statistically significant educational inequalities in people aged {\textless}70 years. Conclusions: We found higher fracture-related mortality with lower education suggesting preventative and therapeutic interventions for fractures should pay special attention to people with low-level education.},
	language = {eng},
	number = {1},
	journal = {Scandinavian Journal of Public Health},
	author = {Lindéus, Maria and Englund, Martin and Kiadaliri, Aliasghar A.},
	month = feb,
	year = {2020},
	pmid = {30345871},
	keywords = {Adult, Aged, Aged, 80 and over, Cause of Death, Cohort Studies, Educational Status, Educational inequality, Female, Fractures, Bone, Health Status Disparities, Hip Fractures, Humans, Male, Middle Aged, Sweden, fracture, mortality, multiple cause of death},
	pages = {72--79},
}

@article{correia_accelerated_2020,
	title = {Accelerated high-resolution free-breathing {3D} whole-heart {T2}-prepared black-blood and bright-blood cardiovascular magnetic resonance},
	volume = {22},
	issn = {1532-429X},
	doi = {10.1186/s12968-020-00691-3},
	abstract = {BACKGROUND: The free-breathing 3D whole-heart T2-prepared Bright-blood and black-blOOd phase SensiTive inversion recovery (BOOST) cardiovascular magnetic resonance (CMR) sequence was recently proposed for simultaneous bright-blood coronary CMR angiography and black-blood late gadolinium enhancement (LGE) imaging. This sequence enables simultaneous visualization of cardiac anatomy, coronary arteries and fibrosis. However, high-resolution ({\textless} 1.4 × 1.4 × 1.4 mm3) fully-sampled BOOST requires long acquisition times of {\textasciitilde} 20 min.
METHODS: In this work, we propose to extend a highly efficient respiratory-resolved motion-corrected reconstruction framework (XD-ORCCA) to T2-prepared BOOST to enable high-resolution 3D whole-heart coronary CMR angiography and black-blood LGE in a clinically feasible scan time. Twelve healthy subjects were imaged without contrast injection (pre-contrast BOOST) and 10 patients with suspected cardiovascular disease were imaged after contrast injection (post-contrast BOOST). A quantitative analysis software was used to compare accelerated pre-contrast BOOST against the fully-sampled counterpart (vessel sharpness and length of the left and right coronary arteries). Moreover, three cardiologists performed diagnostic image quality scoring for clinical 2D LGE and both bright- and black-blood 3D BOOST imaging using a 4-point scale (1-4, non-diagnostic-fully diagnostic). A two one-sided test of equivalence (TOST) was performed to compare the pre-contrast BOOST images. Nonparametric TOST was performed to compare post-contrast BOOST image quality scores.
RESULTS: The proposed method produces images from 3.8 × accelerated non-contrast-enhanced BOOST acquisitions with comparable vessel length and sharpness to those obtained from fully- sampled scans in healthy subjects. Moreover, in terms of visual grading, the 3D BOOST LGE datasets (median 4) and the clinical 2D counterpart (median 3.5) were found to be statistically equivalent (p {\textless} 0.05). In addition, bright-blood BOOST images allowed for visualization of the proximal and middle left anterior descending and right coronary sections with high diagnostic quality (mean score {\textgreater} 3.5).
CONCLUSIONS: The proposed framework provides high-resolution 3D whole-heart BOOST images from a single free-breathing acquisition in {\textasciitilde} 7 min.},
	language = {eng},
	number = {1},
	journal = {Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance},
	author = {Correia, Teresa and Ginami, Giulia and Rashid, Imran and Nordio, Giovanna and Hajhosseiny, Reza and Ismail, Tevfik F. and Neji, Radhouene and Botnar, René M. and Prieto, Claudia},
	month = dec,
	year = {2020},
	pmid = {33317570},
	pmcid = {PMC7737390},
	keywords = {Adult, Aged, Aged, 80 and over, Black-blood, Case-Control Studies, Compressed sensing, Contrast Media, Coronary Vessels, Coronary magnetic resonance angiography (CMRA), Female, Fibrosis, Heart Diseases, Humans, Image navigator, Imaging, Three-Dimensional, Late gadolinium enhancement (LGE), Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Predictive Value of Tests, Reproducibility of Results, Respiratory motion compensation, Workflow, Young Adult},
	pages = {88},
}

Paper  doi  abstract   bibtex   

@article{widerstrom_aspects_2019,
	title = {Aspects influencing clinical reasoning and decision-making when matching treatment to patients with low back pain in primary healthcare},
	volume = {41},
	issn = {2468-7812},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/30818071},
	doi = {10.1016/j.msksp.2019.02.003},
	abstract = {BACKGROUND: It is unclear how physiotherapists match treatment to patients with low-back pain (LBP) in primary healthcare. A further exploration of physiotherapists' perspective of matching treatments to the individual patient in this setting is needed. OBJECTIVE: The aim of this study was to explore and describe aspects influencing physiotherapists' clinical reasoning in the decision-making on individualized treatment of LBP in primary healthcare. DESIGN: This was an explorative study using qualitative content analysis. METHOD: Fifteen semi-structured individual interviews were conducted with physiotherapists, men and women, experienced and novice, working in primary healthcare settings in one sparsely populated region and in one larger city in Sweden. FINDINGS: Two overarching themes were identified influencing decision-making for individualized treatment of LBP: 1) Matching requires differentiation and adaptation, with categories describing specific patient characteristics, assessment findings and treatment adaptations (classification of pain and bodily findings; patient physical capacity and emotions; patient awareness and motivation; treatment combinations and atypical treatment rationales): and 2) The tension between trust and barriers; with categories describing aspects of physiotherapists' convictions, constraints and working environment (confidence in treatments and oneself; physiotherapists' terms overrule patients' preferences; personal constraints and workplace approach and priorities). CONCLUSION: This study describes aspects of the patients, the physiotherapists and their workplaces that influence decisions for individualized treatment of LBP. The findings underpin the need for clinician self-reflection, initiatives for skilled clinical competence and the weight clinician observations carry on the complex treatment selection process which need to be appreciated when implementing evidence-based recommendations in clinical practice.},
	language = {eng},
	journal = {Musculoskeletal science \& practice},
	author = {Widerström, Birgitta and Rasmussen-Barr, Eva and Boström, Carina},
	month = jun,
	year = {2019},
	keywords = {*Attitude of Health Personnel, *Health Knowledge, Attitudes, Practice, *Professional-Patient Relations, Adult, Aged, Aged, 80 and over, Decision Making, Female, Humans, Low Back Pain/*therapy, Male, Middle Aged, Patient Preference/*psychology, Physical Therapists/*psychology, Primary Health Care/*methods, Qualitative Research},
	pages = {6--14},
}

@article{brain_cost-effectiveness_2019,
	title = {Cost-effectiveness analysis of an innovative model of care for chronic wounds patients},
	volume = {14},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0212366},
	abstract = {Current provision of services for the care of chronic wounds in Australia is disjointed and costly. There is large variability in the way that services are provided, and little evidence regarding the cost-effectiveness of a specialist model of care for treatment and management. A decision-analytic model to evaluate the cost-effectiveness of a specialist wound care clinic as compared to usual care for chronic wounds is presented. We use retrospective and prospective data from a cohort of patients as well as information from administrative databases and published literature. Our results show specialist wound clinics are cost-effective for the management of chronic wounds. On average, specialist clinics were \$3,947 cheaper than usual clinics and resulted in a quality adjusted life year gain of 0.04 per patient, per year. Specialist clinics were the best option under multiple scenarios including a different cost perspective and when the cost of a hospital admission was reduced. Current models of care are inefficient and represent low value care, and specialist wound clinics represent a good investment compared to current approaches for the management of chronic wounds in Australia.},
	language = {eng},
	number = {3},
	journal = {PloS One},
	author = {Brain, David and Tulleners, Ruth and Lee, Xing and Cheng, Qinglu and Graves, Nicholas and Pacella, Rosana},
	year = {2019},
	pmid = {30840658},
	pmcid = {PMC6402622},
	keywords = {Adult, Aged, Aged, 80 and over, Australia, Chronic Disease, Cost-Benefit Analysis, Female, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, Quality-Adjusted Life Years, Retrospective Studies, Wound Healing, \_tablet},
	pages = {e0212366}
}

@article{monaro_chaos_2018,
	title = {The chaos of hospitalisation for patients with critical limb ischaemia approaching  major amputation.},
	volume = {27},
	copyright = {© 2018 John Wiley \& Sons Ltd.},
	issn = {1365-2702 0962-1067},
	doi = {10.1111/jocn.14536},
	abstract = {AIMS AND OBJECTIVES: To illuminate the hospital experience for patients and families  when major amputation has been advised for critical limb ischaemia (CLI).  BACKGROUND: CLI creates significant burden to the health system and the family,  particularly as the person with CLI approaches amputation. Major amputation is often  offered as a late intervention for CLI in response to the marked deterioration of an  ischaemic limb, and functional decline from reduced mobility, intractable pain,  infection and/or toxaemia. While a wealth of clinical outcome data on CLI and  amputation exists internationally, little is known about the patient/family-centred  experience of hospitalisation to inform preservation of personhood and  patient-centred care planning. DESIGN: Longitudinal qualitative study using  Heideggerian phenomenology. METHODS: Fourteen patients and 13 family carers provided  a semistructured interview after advice for major amputation. Where amputation  followed, a second interview (6 months postprocedure) was provided by eight patients  and seven family carers. Forty-two semistructured interviews were audio-recorded and  transcribed verbatim. Hermeneutic phenomenological analysis followed. RESULTS:  Hospitalisation for CLI, with or without amputation, created a sense of chaos,  characterised by being fragile and needing more time for care (fragile body and  fragile mind, nurse busyness and carer hypervigilance), being adrift within  uncontrollable spaces (noise, unreliable space, precarious accommodation and  unpredictable scheduling) and being confused by missed and mixed messages (multiple  stakeholders, information overload and cultural/linguistic diversity). CONCLUSIONS:  Patients and families need a range of strategies to assist mindful decision-making  in preparation for amputation in what for them is a chaotic process occurring within  a chaotic environment. Cognitive deficits increase the care complexity and burden of  family advocacy. RELEVANCE TO CLINICAL PRACTICE: A coordinated, interprofessional  response should improve systems for communication, family engagement, operation  scheduling and discharge planning to support preparation, adjustment and allow a  sense of safety to develop. Formal peer support for patients and caregivers should  be actively facilitated.},
	language = {eng},
	number = {19-20},
	journal = {Journal of clinical nursing},
	author = {Monaro, Susan and West, Sandra and Pinkova, Jana and Gullick, Janice},
	month = oct,
	year = {2018},
	pmid = {29776002},
	note = {Place: England},
	keywords = {*Hospitalization, Adult, Aged, Aged, 80 and over, Amputation/*psychology, Caregivers/psychology, Extremities/*blood supply, Female, Humans, Ischemia/*psychology/*surgery, Longitudinal Studies, Male, Middle Aged, Risk Factors, Treatment Outcome, communication, critical limb ischaemia, frailty, major amputation, phenomenology, qualitative research},
	pages = {3530--3543},
}

Paper  doi  abstract   bibtex   

@article{kiadaliri_high_2018,
	title = {High and rising burden of hip and knee osteoarthritis in the {Nordic} region, 1990–2015},
	volume = {89},
	issn = {1745-3674},
	url = {https://doi.org/10.1080/17453674.2017.1404791},
	doi = {10.1080/17453674.2017.1404791},
	abstract = {Background and purpose — Osteoarthritis (OA) imposes a substantial burden on individuals and societies. We report on the burden of knee and hip OA in the Nordic region.Patients and methods — We used the findings from the 2015 Global Burden of Diseases Study to explore prevalence, years lived with disability (YLDs), and disability-adjusted life-years (DALYs) of OA in the 6 Nordic countries during 1990–2015 (population of about 27 million in 2015).Results — During 1990–2015, the number of prevalent OA cases increased by 43\% to 1,507,587 (95\% uncertainty interval [UI] 1,454,338–1,564,778) in the region. OA accounted for 1.3\% (UI 1.0–1.7) of YLDs in 1990, increasing to 1.6\% (UI 1.2–2.0) in 2015. Of 315 causes studied, OA was the 15th leading cause of YLDs, causing 52,661 (UI 34,056–77,499) YLDs in 2015; of these 23\% were attributable to high body mass index. The highest relative importance of OA was reported for women aged 65–74 years (8th leading cause of YLDs in 2015). Among the top 30 leading causes of YLDs in the region, OA had the 5th greatest relative increase in total YLDs during 1990–2015. From 1990 to 2015, increase in age-standardized YLDs from OA in the region was slightly lower than increase at the global level (7.5\% vs. 10.5\%). OA was, however, responsible for a higher proportional burden of DALYs in the region compared with the global level.Interpretation — The OA burden is high and rising in the Nordic region. With population growth, aging, and the obesity epidemic, a substantial rise in the burden of OA is expected and should be addressed in health policies.},
	number = {2},
	journal = {Acta Orthopaedica},
	author = {Kiadaliri, Aliasghar A. and Lohmander, L. Stefan and Moradi-Lakeh, Maziar and Petersson, Ingemar F. and Englund, Martin},
	month = mar,
	year = {2018},
	pmid = {29160139},
	keywords = {Adult, Age Distribution, Aged, Aged, 80 and over, Body Mass Index, Cost of Illness, Female, Humans, Male, Middle Aged, Osteoarthritis, Hip, Osteoarthritis, Knee, Prevalence, Quality-Adjusted Life Years, Scandinavian and Nordic Countries, Sex Distribution},
	pages = {177--183},
}

Paper  doi  abstract   bibtex   

@article{ahlen_bergman_increased_2018,
	title = {Increased {CD}4(+) {T} cell lineage commitment determined by {CpG} methylation correlates with better prognosis in urinary bladder cancer patients},
	volume = {10},
	issn = {1868-7083},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/30075815},
	doi = {10.1186/s13148-018-0536-6},
	abstract = {BACKGROUND: Urinary bladder cancer is a common malignancy worldwide. Environmental factors and chronic inflammation are correlated with the disease risk. Diagnosis is performed by transurethral resection of the bladder, and patients with muscle invasive disease preferably proceed to radical cystectomy, with or without neoadjuvant chemotherapy. The anti-tumour immune responses, known to be initiated in the tumour and draining lymph nodes, may play a major role in future treatment strategies. Thus, increasing the knowledge of tumour-associated immunological processes is important. Activated CD4(+) T cells differentiate into four main separate lineages: Th1, Th2, Th17 and Treg, and they are recognized by their effector molecules IFN-γ, IL-13, IL-17A, and the transcription factor Foxp3, respectively. We have previously demonstrated signature CpG sites predictive for lineage commitment of these four major CD4(+) T cell lineages. Here, we investigate the lineage commitment specifically in tumour, lymph nodes and blood and relate them to the disease stage and response to neoadjuvant chemotherapy. RESULTS: Blood, tumour and regional lymph nodes were obtained from patients at time of transurethral resection of the bladder and at radical cystectomy. Tumour-infiltrating CD4(+) lymphocytes were significantly hypomethylated in all four investigated lineage loci compared to CD4(+) lymphocytes in lymph nodes and blood (lymph nodes vs tumour-infiltrating lymphocytes: IFNG -4229 bp p {\textless} 0.0001, IL13 -11 bp p {\textless} 0.05, IL17A -122 bp p {\textless} 0.01 and FOXP3 -77 bp p {\textgreater} 0.05). Examination of individual lymph nodes displayed different methylation signatures, suggesting possible correlation with future survival. More advanced post-cystectomy tumour stages correlated significantly with increased methylation at the IFNG -4229 bp locus. Patients with complete response to neoadjuvant chemotherapy displayed significant hypomethylation in CD4(+) T cells for all four investigated loci, most prominently in IFNG p {\textless} 0.0001. Neoadjuvant chemotherapy seemed to result in a relocation of Th1-committed CD4(+) T cells from blood, presumably to the tumour, indicated by shifts in the methylation patterns, whereas no such shifts were seen for lineages corresponding to IL13, IL17A and FOXP3. CONCLUSION: Increased lineage commitment in CD4(+) T cells, as determined by demethylation in predictive CpG sites, is associated with lower post-cystectomy tumour stage, complete response to neoadjuvant chemotherapy and overall better outcome, suggesting epigenetic profiling of CD4(+) T cell lineages as a useful readout for clinical staging.},
	language = {eng},
	number = {1},
	journal = {Clinical epigenetics},
	author = {Ahlén Bergman, Emma and Hartana, Ciputra Adijaya and Johansson, Markus and Linton, Ludvig B and Berglund, Sofia and Hyllienmark, Martin and Lundgren, Christian and Holmström, Benny and Palmqvist, Karin and Hansson, Johan and Alamdari, Farhood and Huge, Ylva and Aljabery, Firas and Riklund, Katrine and Winerdal, Malin E and Krantz, David and Zirakzadeh, A Ali and Marits, Per and Sjöholm, Louise K and Sherif, Amir and Winqvist, Ola},
	month = aug,
	year = {2018},
	keywords = {*CD4-positive T lymphocytes, *DNA Methylation, *DNA methylation, *Urinary bladder neoplasms, Aged, Aged, 80 and over, CD4-Positive T-Lymphocytes/*cytology/immunology, Cell Differentiation, Cell Lineage, Cells, Cultured, CpG Islands, Cystectomy, Drug Therapy, Epigenesis, Genetic, Female, Forkhead Transcription Factors/genetics, Humans, Interferon-gamma/genetics, Interleukin-13/genetics, Interleukin-17/genetics, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Prognosis, Sequence Analysis, DNA/*methods, Treatment Outcome, Urinary Bladder Neoplasms/genetics/immunology/*pathology/*surgery},
	pages = {102--102}
}

@article{muller_development_2018,
	title = {The development and validation of different decision-making tools to predict urine culture growth out of urine flow cytometry parameter},
	volume = {13},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0193255},
	abstract = {OBJECTIVE: Patients presenting with suspected urinary tract infection are common in every day emergency practice. Urine flow cytometry has replaced microscopic urine evaluation in many emergency departments, but interpretation of the results remains challenging. The aim of this study was to develop and validate tools that predict urine culture growth out of urine flow cytometry parameter.
METHODS: This retrospective study included all adult patients that presented in a large emergency department between January and July 2017 with a suspected urinary tract infection and had a urine flow cytometry as well as a urine culture obtained. The objective was to identify urine flow cytometry parameters that reliably predict urine culture growth and mixed flora growth. The data set was split into a training (70\%) and a validation set (30\%) and different decision-making approaches were developed and validated.
RESULTS: Relevant urine culture growth (respectively mixed flora growth) was found in 40.2\% (7.2\% respectively) of the 613 patients included. The number of leukocytes and bacteria in flow cytometry were highly associated with urine culture growth, but mixed flora growth could not be sufficiently predicted from the urine flow cytometry parameters. A decision tree, predictive value figures, a nomogram, and a cut-off table to predict urine culture growth from bacteria and leukocyte count were developed, validated and compared.
CONCLUSIONS: Urine flow cytometry parameters are insufficient to predict mixed flora growth. However, the prediction of urine culture growth based on bacteria and leukocyte count is highly accurate and the developed tools should be used as part of the decision-making process of ordering a urine culture or starting an antibiotic therapy if a urogenital infection is suspected.},
	language = {eng},
	number = {2},
	journal = {PloS One},
	author = {Müller, Martin and Seidenberg, Ruth and Schuh, Sabine K. and Exadaktylos, Aristomenis K. and Schechter, Clyde B. and Leichtle, Alexander B. and Hautz, Wolf E.},
	year = {2018},
	pmid = {29474463},
	pmcid = {PMC5825091},
	keywords = {Adult, Aged, Aged, 80 and over, Bacteria, Decision Making, Emergency Service, Hospital, Female, Flow Cytometry, Humans, Leukocytes, Male, Middle Aged, Urinary Tract Infections, Urine},
	pages = {e0193255},
}

@article{koyama_serum_2017,
	title = {Serum ferritin level is a prognostic marker in patients with peripheral {T}-cell lymphoma},
	volume = {39},
	issn = {1751-553X},
	doi = {10.1111/ijlh.12592},
	abstract = {INTRODUCTION

The prognostic value of serum ferritin level in patients with peripheral T-cell lymphoma (PTCL) remains unknown.


METHODS

We retrospectively analyzed clinical data from 78 consecutive patients with newly diagnosed PTCL that were treated with anthracycline-containing regimens between 1998 and 2011.


RESULTS

The patients consisted of 50 males and 28 females with a median age of 64 years (range, 16-83 years). The subtypes of PTCL were 39 PTCL, not otherwise specified and 39 angioimmunoblastic T-cell lymphoma (AITL). The median observation period for the surviving patients was 50 months. The overall survival (OS) was poorer in patients with serum ferritin level above the upper normal limit (n = 28), compared with patients with serum ferritin level within normal range (n = 50; 4-year OS: 23\% vs. 72\%; P {\textless} 0.001). In the multivariate analysis, poor performance status (P = 0.006) and elevated serum ferritin level (P = 0.018) were independent risk factors for poor OS.


CONCLUSION

Serum ferritin level is a useful prognostic marker for PTCL.},
	number = {1},
	journal = {International journal of laboratory hematology},
	author = {Koyama, S and Fujisawa, S and Watanabe, R and Itabashi, M and Ishibashi, D and Ishii, Y and Hattori, Y and Nakajima, Y and Motohashi, K and Takasaki, H and Kawasaki, R and Hashimoto, C and Yamazaki, E and Koharazawa, H and Takemura, S and Tomita, N and Sakai, R and Motomura, S and Nakajima, H},
	month = feb,
	year = {2017},
	pmid = {27885817},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Anthracyclines, Disease-Free Survival, Female, Ferritins, Humans, Lymphoma, T-Cell, Peripheral, Male, Middle Aged, Retrospective Studies, Survival Rate},
	pages = {112--117}
}

Paper  abstract   bibtex   

@article{correa-selm_use_2017,
	title = {Use of {Biologics} in {Private} {Practice}: {Nine} {Years} of {Lessons} and {Learning}},
	volume = {16},
	copyright = {All rights reserved},
	issn = {1545-9616 (Print) 1545-9616 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/28301616},
	abstract = {{\textless}p{\textgreater}Over a decade ago, the FDA approved biologics for psoriasis, which changed how the disease is treated and, in most cases, has a significant positive impact on the lives of patients. Side effects primarily identified during the investigational and research phase led to the development of specific guidelines for treatment. The treatment guidelines have been amended to incorporate better understandings of side-effects over the years that the disease has been treated. In this study, we focused on a chart review that included assessing the current guidelines and their alignment with modern patient management and the recent side effects presented. This life-cycle evaluation included over 100 patients, management of their treatment, laboratory abnormalities, criteria for choosing or changing to a different biologic, and the effects of the treatments management throughout the years. The review identified some recommended changes in the application and treatment of psoriasis with biologics. To further evidence our findings, we hope to expand this study to a larger scale with more patients.{\textless}/p{\textgreater} {\textless}p{\textgreater}{\textless}em{\textgreater}J Drugs Dermatol. 2017;16(3):215-217.{\textless}/em{\textgreater}{\textless}/p{\textgreater}.},
	number = {3},
	journal = {J Drugs Dermatol},
	author = {Correa-Selm, L. M. and Alamgir, M. and Rao, B. K.},
	month = mar,
	year = {2017},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Biological Products/administration \& dosage/adverse effects/*therapeutic use, Child, Female, Humans, Male, Middle Aged, Practice Guidelines as Topic, Private Practice/*trends, Psoriasis/blood/*drug therapy, Quality of Life, Retrospective Studies, Severity of Illness Index, Young Adult},
	pages = {215--217},
}

Paper  doi  bibtex   

@article{giordano_j_lung_2017,
title = {Lung perfusion characteristics in pulmonary arterial hypertension (PAH) and peripheral forms of chronic thromboembolic pulmonary hypertension (pCTEPH): Dual-energy CT experience in 31 patients},
volume = {27},
issn = {0938-7994},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27480438},
DOI = {10.1007/s00330-016-4500-6},
Language = {English},
Journal = {Eur. Radiol.},
author = {{Giordano J} and {Khung S} and {Duhamel A} and {Hossein-Foucher C} and {Bellèvre D} and {Lamblin N} and {Remy J} and {Remy-Jardin M}},
year = {2017},
keywords = {Adult, Aged, Aged, 80 and over, Angiography/methods, Chronic Disease, Diagnosis, Differential, Female, Humans, Hypertension, Pulmonary/diagnostic imaging*, Hypertension, Pulmonary/etiology, Male, Middle Aged, Perfusion Imaging/methods, Pulmonary Embolism/complications, Pulmonary Embolism/diagnostic imaging*, Tomography, X-Ray Computed/methods, Young Adult},
pages = {1631-1639}
}

@article{hirakawa_content_2017,
	title = {Content of advance care planning among {Japanese} elderly people living at home: {A}  qualitative study.},
	volume = {70},
	copyright = {Copyright © 2017 Elsevier B.V. All rights reserved.},
	issn = {1872-6976 0167-4943},
	doi = {10.1016/j.archger.2017.01.007},
	abstract = {PURPOSE OF STUDY: Elderly peoples' values and preferences for end-of-life care have  not yet known in details. The aim of the present study was to investigate the  end-of-life wishes and decision making among Japanese elderly people who required  home care services. The study was designed to qualitative research strategies, using  face to face interview data recorded in nursing care records, with a focus on  advance care planning. DESIGN AND METHODS: A total of 102 elderly people (47 males,  55 females) of 6 home care support offices in Hyogo prefecture participated. RESULTS  AND IMPLICATIONS: We finally extracted the following 5 themes: anxiety about the  future, abandonment of control, clinging to current daily life, precarious mutual  support, delegating decision-making. While elderly people living at home generally  feel anxious and fearful about the future, they seemed to try to avoid thinking too  seriously about possible complications in their life. They also tend to leave  end-of-life decision to someone else, and their decisions tend to change as they  advance in age and as their condition deteriorates. Our findings suggest that  medical professionals and care managers always support their patients' decisions,  allowing for the views of the informal caregivers on whom elderly people rely for  decision-making.},
	language = {eng},
	journal = {Archives of gerontology and geriatrics},
	author = {Hirakawa, Yoshihisa and Chiang, Chifa and Hilawe, Esayas Haregot and Aoyama, Atsuko},
	month = jun,
	year = {2017},
	pmid = {28171836},
	note = {Place: Netherlands},
	keywords = {*Advance Care Planning, *Decision Making, Activities of Daily Living, Aged, Aged, 80 and over, Anxiety/psychology, Decision making, End-of-life care, Female, Humans, Japan, Living will, Male, Middle Aged, Personal Autonomy, Proxy, Qualitative study, Social Support},
	pages = {162--168},
}

@article{kuo_climbing_2017,
	title = {Climbing fiber-{Purkinje} cell synaptic pathology in tremor and cerebellar degenerative diseases},
	volume = {133},
	issn = {1432-0533},
	doi = {10.1007/s00401-016-1626-1},
	abstract = {Changes in climbing fiber-Purkinje cell (CF-PC) synaptic connections have been found in the essential tremor (ET) cerebellum, and these changes are correlated with tremor severity. Whether these postmortem changes are specific to ET remains to be investigated. We assessed CF-PC synaptic pathology in the postmortem cerebellum across a range of degenerative movement disorders [10 Parkinson's disease (PD) cases, 10 multiple system atrophy (MSA) cases, 10 spinocerebellar ataxia type 1 (SCA1) cases, and 20 ET cases] and 25 controls. We observed differences in terms of CF pathological features across these disorders. Specifically, PD cases and ET cases both had more CFs extending into the parallel fiber (PF) territory, but ET cases had more complex branching and increased length of CFs in the PF territory along with decreased CF synaptic density compared to PD cases. MSA cases and SCA1 cases had the most severely reduced CF synaptic density and a marked paucity of CFs extending into the PF territory. Furthermore, CFs in a subset of MSA cases formed collateral branches parallel to the PC layer, a feature not seen in other diagnostic groups. Using unsupervised cluster analysis, the cases and controls could all be categorized into four clusters based on the CF pathology and features of PC pathology, including counts of PCs and their axonal torpedoes. ET cases and PD cases co-segregated into two clusters, whereas SCA1 cases and MSA cases formed another cluster, separate from the control cluster. Interestingly, the presence of resting tremor seemed to be the clinical feature that separated the cases into the two ET-PD clusters. In conclusion, our study demonstrates that these degenerative movement disorders seem to differ with respect to the pattern of CF synaptic pathology they exhibit. It remains to be determined how these differences contribute to the clinical presentations of these diseases.},
	language = {eng},
	number = {1},
	journal = {Acta Neuropathologica},
	author = {Kuo, Sheng-Han and Lin, Chi-Ying and Wang, Jie and Sims, Peter A. and Pan, Ming-Kai and Liou, Jyun-You and Lee, Danielle and Tate, William J. and Kelly, Geoffrey C. and Louis, Elan D. and Faust, Phyllis L.},
	month = jan,
	year = {2017},
	pmid = {27704282},
	pmcid = {PMC5481163},
	keywords = {Aged, Aged, 80 and over, Climbing fiber, Cluster Analysis, Essential Tremor, Essential tremor, Female, Humans, Image Interpretation, Computer-Assisted, Immunohistochemistry, Male, Middle Aged, Multiple System Atrophy, Multiple system atrophy, Neural Pathways, Olivary Nucleus, Parkinson Disease, Parkinson’s disease, Purkinje Cells, Purkinje cell, Severity of Illness Index, Spinocerebellar Ataxias, Spinocerebellar ataxia, Synapses, Tremor, Unsupervised Machine Learning, Vesicular Glutamate Transport Protein 2},
	pages = {121--138},
}

@article{failing_lymphocyte--monocyte_2017,
	title = {Lymphocyte-to-monocyte ratio is associated with survival in pembrolizumab-treated metastatic melanoma patients},
	volume = {27},
	issn = {1473-5636},
	doi = {10.1097/CMR.0000000000000404},
	abstract = {The peripheral blood lymphocyte-to-monocyte ratio (LMR) has been associated with prognosis in many malignancies including metastatic melanoma. However, it has not been studied in patients treated with immune checkpoint inhibitors. In this study, we analyzed the baseline LMR with progression-free survival (PFS) and overall survival (OS) in metastatic melanoma patients treated with pembrolizumab. A total of 133 patients with metastatic melanoma treated with pembrolizumab were included in this retrospective study. LMR was calculated from pretherapy peripheral blood counts and the optimal cutoff value was determined by a receiver operator characteristic curve. PFS and OS were evaluated using the Kaplan-Meier method and multivariate Cox proportional hazard modeling. Patients with an LMR of at least 1.7 showed improved PFS (hazard ratio=0.55; 95\% confidence interval: 0.34-0.92; P=0.024) and OS (hazard ratio=0.29; 95\% confidence interval: 0.15-0.59; P=0.0007). The baseline LMR is associated with PFS and OS in metastatic melanoma patients treated with pembrolizumab, and could represent a convenient and cost-effective prognostic biomarker. Validation of these findings in an independent cohort is needed.},
	language = {eng},
	number = {6},
	journal = {Melanoma Research},
	author = {Failing, Jarrett J. and Yan, Yiyi and Porrata, Luis F. and Markovic, Svetomir N.},
	year = {2017},
	pmid = {29016387},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Female, Humans, Lymphocytes, Male, Melanoma, Middle Aged, Monocytes, Prognosis, Retrospective Studies, Young Adult},
	pages = {596--600},
}

@article{pascual_bloodstream_2016,
	title = {Bloodstream infections caused by {Escherichia} coli producing {AmpC} β-lactamases: epidemiology and clinical features},
	volume = {35},
	issn = {1435-4373},
	shorttitle = {Bloodstream infections caused by {Escherichia} coli producing {AmpC} β-lactamases},
	doi = {10.1007/s10096-016-2752-3},
	abstract = {The aim of the study was to investigate the epidemiology and clinical features of bloodstream infections due to Escherichia coli producing AmpC β-lactamases (AmpC-Ec-BSI). In a multi-centre case-control study, all third-generation-cephalosporin-resistant Escherichia coli BSI (3GC-Ec-BSI) isolates were analysed. Acquired bla AmpC (bla ac-AmpC) detection was done by polymerase chain reaction (PCR) and sequencing. Chromosomal bla AmpC (bla c-AmpC) expression was quantified by real-time PCR. Cases were patients with AmpC-Ec-BSI. Controls were patients with cephalosporin-susceptible E. coli BSI, matched 1:1 by sex and age. Demographics, comorbidities, intrinsic and extrinsic risk factors for antimicrobial resistance, clinical presentation and outcomes were investigated. Among 841 E. coli BSI, 17 were caused by AmpC-Ec (2 \%). Eleven isolates (58.8 \%) had bla ac-AmpC and six were bla c-AmpC overproducers. The mean age of cases was 66.2 years and 71 \% were men. Cases were more frequently healthcare-related (82 vs. 52 \% controls, p {\textless} 0.05) and presented more intrinsic and extrinsic risk factors. At least one risk factor was present in 94.1 \% of cases vs. 41.7 \% of controls (p = 0.002). Severity and length of stay (LOS) were higher among cases (mean Pitt Score 2.6 vs. 0.38 in controls, p = 0.03; LOS 17.5 days vs. 6 in controls, p = 0.02). Inappropriate empirical therapy (IET) was administered to 70.6 \% of cases and 23.5 \% of controls (p {\textless} 0.003). No differences were found in terms of cure rate at the 14th day and mortality. Bloodstream infections due to AmpC-Ec (mostly plasmid-mediated) are infrequent in our area. AmpC-Ec-BSI affects mainly patients with intrinsic risk factors and those with previous antibiotic exposure. A high proportion received IET.},
	language = {eng},
	number = {12},
	journal = {European Journal of Clinical Microbiology \& Infectious Diseases: Official Publication of the European Society of Clinical Microbiology},
	author = {Pascual, V. and Alonso, N. and Simó, M. and Ortiz, G. and Garcia, M. C. and Xercavins, M. and Rivera, A. and Morera, M. A. and Miró, E. and Espejo, E. and Navarro, F. and Gurguí, M. and Pérez, J. and Rodríguez-Carballeira, M. and Garau, J. and Calbo, E.},
	year = {2016},
	pmid = {27549108},
	keywords = {Adult, Age Distribution, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacteremia, Bacterial Proteins, Case-Control Studies, DNA, Bacterial, Escherichia coli, Escherichia coli Infections, Female, Humans, Length of Stay, Male, Middle Aged, Polymerase Chain Reaction, Risk Factors, Sequence Analysis, DNA, Severity of Illness Index, Treatment Outcome, beta-Lactamases},
	pages = {1997--2003},
}

@article{kiadaliri_absolute_2016,
	title = {Absolute and relative educational inequalities in obesity among adults in {Tehran}: {Findings} from the {Urban} {HEART} {Study}-2.},
	volume = {10 Suppl 1},
	issn = {1871-403X},
	shorttitle = {Absolute and relative educational inequalities in obesity among adults in {Tehran}},
	doi = {10.1016/j.orcp.2015.05.002},
	abstract = {BACKGROUND: The prevalence of obesity is increasing in Iran. Previous studies showed mixed results in relation to association between socioeconomic status and obesity in the country. The current study aimed to examine educational inequalities among adults in Tehran in 2011.
METHOD: Data on 90,435 persons 18 years and older from Urban Health Equity Assessment and Response Tool (Urban HEART-2) were analyzed. The Slope Index of Inequality (SII) and the Relative Index of Inequality (RII) were used for assessing educational inequalities in obesity. These measures were quantified using generalized linear models for the binomial family adjusted for sex and age. Subgroup analysis was conducted across sex, age groups and the 22 districts of Tehran.
RESULTS: Both SII and RII showed substantial educational inequalities in obesity in favour of more educated adults [RII and SII (95\% CI were equal to 2.91 (2.71-3.11) and 0.12 (0.12-0.13)), respectively]. These educational inequalities were persistent even after adjusting for employment, marital status and smoking. Subgroup analysis revealed that educational inequalities were more profound among women. While among men educational inequalities were generally increasing with age, an inverse trend was observed among women. Educational inequalities were observed within all 22 districts of Tehran and generally there were no statistically significant differences between districts.
CONCLUSION: An inverse association between education and obesity was observed in the current study. To decrease educational inequalities in Tehran, priority should be given to younger women and older men. Further analyses are needed to explain these inequalities.},
	language = {eng},
	journal = {Obesity Research \& Clinical Practice},
	author = {Kiadaliri, Aliasghar A. and Asadi-Lari, Mohsen and Kalantari, Naser and Jafari, Mehdi and Vaez Mahdavi, Mohammad Reza and Faghihzadeh, Soghrat},
	month = sep,
	year = {2016},
	pmid = {26003304},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Educational Status, Educational inequality, Female, Generalized linear model, Humans, Iran, Male, Middle Aged, Obesity, Sex Factors, Social Class, Socioeconomic Factors, Urban-HEART, Young Adult},
	pages = {S57--S63},
}

@article{cuervo_clinical_2016,
	title = {Clinical characteristics, treatment and outcomes of {MRSA} bacteraemia in the elderly},
	volume = {72},
	issn = {1532-2742},
	doi = {10.1016/j.jinf.2015.12.009},
	abstract = {OBJECTIVES: To compare clinical and microbiological characteristics, treatment and outcomes of MRSA bacteraemia among elderly and younger patients.
MATERIAL AND METHODS: Prospective study conducted at 21 Spanish hospitals including patients with MRSA bacteraemia diagnosed between June/2008 and December/2009. Episodes diagnosed in patients aged 75 or more years old (≥75) were compared with the rest of them ({\textless}75).
RESULTS: Out of 579 episodes of MRSA bacteraemia, 231 (39.9\%) occurred in patients ≥75. Comorbidity was significantly higher in older patients (Charlson score ≥4: 52.8 vs. 44\%; p = .037) as was the severity of the underlying disease (McCabe ≥1: 61.9 vs. 43.4\%; p {\textless} .001). In this group the acquisition was more frequently health-care related (43.3 vs. 33.9\%, p = .023), mostly from long-term care centers (12.1 vs. 3.7\%, p {\textless} .001). An unknown focus was more frequent among ≥75 (19.9 vs. 13.8\%; p = .050) while severity at presentation was similar between groups (Pitt score ≥3: 31.2 vs. 27.6\%; p = .352). The prevalence of vancomycin resistant isolates was similar between groups, as was the appropriateness of empirical antibiotic therapy. Early (EM) and overall mortality (OM) were significantly more frequent in the ≥75 group (EM: 12.1 vs. 6\%; p = .010 OM: 42.9 vs. 23\%; p {\textless} .001). In multivariate analysis age ≥75 was an independent risk factor for overall mortality (aOR: 2.47, CI: 1.63-3.74; p {\textless} .001).
CONCLUSION: MRSA bacteraemia was frequent in patients aged ≥75 of our cohort. This group had higher comorbidity rates and the source of infection was more likely to be unknown. Although no differences were seen in severity or adequacy of empiric therapy, elderly patients showed a higher overall mortality.},
	language = {eng},
	number = {3},
	journal = {Journal of Infection},
	author = {Cuervo, Guillermo and Gasch, Oriol and Shaw, Evelyn and Camoez, Mariana and Domínguez, María Ángeles and Padilla, Belén and Pintado, Vicente and Almirante, Benito and Lepe, José A. and López-Medrano, Francisco and Ruiz de Gopegui, Enrique and Martínez, José A. and Montejo, José Miguel and Perez-Nadales, Elena and Arnáiz, Ana and Goenaga, Miguel Ángel and Benito, Natividad and Horcajada, Juan Pablo and Rodríguez-Baño, Jesús and Pujol, Miquel and {REIPI/GEIH study group}},
	year = {2016},
	pmid = {26723914},
	keywords = {Age Factors, Aged, Aged, 80 and over, Bacteraemia, Bacteremia, Elderly, Female, Hospitals, Humans, MRSA, Male, Methicillin-Resistant Staphylococcus aureus, Prospective Studies, Spain, Staphylococcal Infections, Treatment Outcome},
	pages = {309--316},
}

@article{kuo_deep_2016,
	title = {Deep brain stimulation and climbing fiber synaptic pathology in essential tremor},
	volume = {80},
	issn = {1531-8249},
	doi = {10.1002/ana.24728},
	abstract = {Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461-465.},
	language = {eng},
	number = {3},
	journal = {Annals of Neurology},
	author = {Kuo, Sheng-Han and Lin, Chi-Ying and Wang, Jie and Liou, Jyun-You and Pan, Ming-Kai and Louis, Ravi J. and Wu, Wei-Pu and Gutierrez, Jesus and Louis, Elan D. and Faust, Phyllis L.},
	month = sep,
	year = {2016},
	pmid = {27422481},
	pmcid = {PMC5016237},
	keywords = {Aged, Aged, 80 and over, Cerebellar Diseases, Deep Brain Stimulation, Essential Tremor, Female, Humans, Male, Nerve Fibers, Severity of Illness Index, Synapses},
	pages = {461--465},
}

Website  abstract   bibtex   

@article{
 title = {Problematic internet use (PIU): Associations with the impulsive-compulsive spectrum. An application of machine learning in psychiatry},
 type = {article},
 year = {2016},
 identifiers = {[object Object]},
 keywords = {ADHD,Adolescent,Adult,Aged,Aged, 80 and over,Behavior, Addictive,Compulsive Behavior,Compulsivity,Female,Humans,Impulsivity,Internet,Internet use,Machine Learning,Machine learning,Male,Middle Aged,OCD,Obsessive-Compulsive Disorder,Online Systems,Predictive Value of Tests,Psychiatry,ROC Curve,Reproducibility of Results,South Africa,Surveys and Questionnaires,United States,Young Adult},
 pages = {94-102},
 volume = {83},
 websites = {http://files/1161/Ioannidis et al. - 2016 - Problematic internet use (PIU) Associations with .pdf,http://www.ncbi.nlm.nih.gov/pubmed/27580487},
 id = {018be67c-9f6d-3317-bdff-f0e36f34becb},
 created = {2020-09-17T09:27:55.706Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:55.706Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 language = {eng},
 private_publication = {false},
 abstract = {Problematic internet use is common, functionally impairing, and in need of further study. Its relationship with obsessive-compulsive and impulsive disorders is unclear. Our objective was to evaluate whether problematic internet use can be predicted from recognised forms of impulsive and compulsive traits and symptomatology. We recruited volunteers aged 18 and older using media advertisements at two sites (Chicago USA, and Stellenbosch, South Africa) to complete an extensive online survey. State-of-the-art out-of-sample evaluation of machine learning predictive models was used, which included Logistic Regression, Random Forests and Naïve Bayes. Problematic internet use was identified using the Internet Addiction Test (IAT). 2006 complete cases were analysed, of whom 181 (9.0%) had moderate/severe problematic internet use. Using Logistic Regression and Naïve Bayes we produced a classification prediction with a receiver operating characteristic area under the curve (ROC-AUC) of 0.83 (SD 0.03) whereas using a Random Forests algorithm the prediction ROC-AUC was 0.84 (SD 0.03) [all three models superior to baseline models p < 0.0001]. The models showed robust transfer between the study sites in all validation sets [p < 0.0001]. Prediction of problematic internet use was possible using specific measures of impulsivity and compulsivity in a population of volunteers. Moreover, this study offers proof-of-concept in support of using machine learning in psychiatry to demonstrate replicability of results across geographically and culturally distinct settings.},
 bibtype = {article},
 author = {Ioannidis, Konstantinos and Chamberlain, Samuel R and Treder, Matthias S and Kiraly, Franz and Leppink, Eric W and Redden, Sarah A and Stein, Dan J and Lochner, Christine and Grant, Jon E},
 journal = {Journal of Psychiatric Research}
}

@article{k_sunny_interpreting_2016,
	title = {Interpreting the {Lactulose} {Breath} {Test} for the {Diagnosis} of {Small} {Intestinal} {Bacterial} {Overgrowth}},
	volume = {351},
	issn = {1538-2990},
	doi = {10.1016/j.amjms.2015.12.008},
	abstract = {INTRODUCTION: Based on literature review, a positive lactulose breath test (LBT) for small intestinal bacterial overgrowth requires an initial peak value of hydrogen within 100 minutes of lactulose ingestion with a second peak before 180minutes. However, using scintigraphic monitoring of lactulose transit time, mean oral-cecal arrival time has been reported as 73minutes. The goal was to propose new criteria for analysing the LBT to overcome false positive interpretations.
METHODS: LBTs from our referral center were interpreted as positive after ingestion of 10g of lactulose using the following approach for hydrogen concentrations: (1) The literature guidelines: greater than 20ppm from a baseline less than 10ppm achieved within 100minutes followed by a further rise of greater than 15ppm within 180minutes. (2) The proposed criteria: greater than 20ppm from a baseline less than 10ppm within either 60 or 80minutes followed by a further rise of greater than 15ppm during the 180-minute test.
RESULTS: A total of 153 patients with symptoms suspicious for small-bowel bacterial overgrowth underwent testing. Of all, 26.1\% patients tested positive by 100minutes, 11.8\% patients tested positive by 60minutes and 18.3\% patients tested positive by 80minutes. The percentage of positive LBTs at 60 and 80minutes was significantly lesser than for the 100minutes criteria (P {\textless} 0.05).
CONCLUSIONS: The first hydrogen peak increase should occur by either 60 or 80minutes to increase the specificity of LBT for small intestinal bacterial overgrowth based on the reality of lactulose cecal arrival times.},
	language = {eng},
	number = {3},
	journal = {The American Journal of the Medical Sciences},
	author = {K Sunny, Joseph and Garcia, Cesar J. and McCallum, Richard W.},
	month = mar,
	year = {2016},
	pmid = {26992249},
	keywords = {Adult, Aged, Aged, 80 and over, Bacterial Infections, Bloating, Breath Tests, Diarrhea, Female, Gastrointestinal Agents, Humans, Hydrogen, Intestine, Small, Lactulose, Lactulose breath test, Male, Middle Aged, Retrospective Studies, Small intestinal bacterial overgrowth, Young Adult},
	pages = {229--232},
}

@article{garbati_infections_2016,
	title = {Infections due to {Carbapenem} {Resistant} {Enterobacteriaceae} among {Saudi} {Arabian} {Hospitalized} {Patients}: {A} {Matched} {Case}-{Control} {Study}.},
	volume = {2016},
	issn = {2314-6141},
	abstract = {Background. We conducted this case-control study to determine the risk factors and treatment outcome of infections due to carbapenem resistant Enterobacteriaceae in our institution. Methods. This is a matched case-control study of patients with infection due to carbapenem resistant Enterobacteriaceae (CRE) and carbapenem susceptible Enterobacteriaceae (CSE), from Riyadh, Saudi Arabia, between March 2012 and December 2013. Results. During this period, 29 cases and 58 controls were studied. The mean ages of the cases (55.4 years) and controls (54.7 years) were similar (p = 0.065). Cases had higher mean Charlson comorbidity index (CCI) (3.1) than controls (1.9), p = 0.026. Several factors contributed to infection among the studied population. Prior uses of piperacillin-tazobactam, a carbapenem, a quinolone, and metronidazole were significantly associated with CRE infections. Nine of the cases died compared with 7 of the controls, p = 0.031. Mortality was associated with advanced age, the presence of comorbidities, ICU stay, and receipt of invasive procedures. Conclusions. Infections due to CRE resulted in a significantly increased mortality. Combination antibiotic therapy was associated with reduced mortality. Properly designed randomized controlled studies are required to better characterize these findings.},
	number = {101600173},
	journal = {BioMed research international},
	author = {Garbati, M A and Sakkijha, H and Abushaheen, A},
	year = {2016},
	note = {Garbati, M A. Section of Infectious Diseases, Medical Specialties Department, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia.
Sakkijha, H. Pulmonary and Critical Care Medicine Department, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia.
Abushaheen, A. Scientific Research and Publication Center, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia.},
	keywords = {*Carbapenems/tu [Therapeutic Use], *Cross Infection/dt [Drug Therapy], *Cross Infection/mo [Mortality], *Drug Resistance, Bacterial, *Enterobacteriaceae Infections/dt [Drug Therapy], *Enterobacteriaceae Infections/mo [Mortality], Aged, 80 and over, Case-Control Studies, Cross Infection/mi [Microbiology], Enterobacteriaceae Infections/mi [Microbiology], Enterobacteriaceae/cl [Classification], Enterobacteriaceae/de [Drug Effects], Enterobacteriaceae/ip [Isolation \& Purification], Hospitalization/sn [Statistics \& Numerical Data], Humans, Risk Factors, Saudi Arabia/ep [Epidemiology], adolescent, adult, aged, female, incidence, male, middle aged, survival rate, treatment outcome, young adult},
	pages = {3961684}
}

@article{ye_telemedicine_2016,
	title = {A telemedicine wound care model using {4G} with smart phones or smart glasses: {A} pilot study},
	volume = {95},
	issn = {1536-5964},
	shorttitle = {A telemedicine wound care model using {4G} with smart phones or smart glasses},
	doi = {10.1097/MD.0000000000004198},
	abstract = {To assess the feasibility of a wound care model using 4th-generation mobile communication technology standards (4G) with smart phones or smart glasses for wound management.This wound care model is an interactive, real-time platform for implementing telemedicine changing wound dressings, or doing operations. It was set up in March 2015 between Jinhua in Zhejiang province and Shanghai, China, which are 328 km apart. It comprised of a video application (APP), 4G net, smart phones or smart glasses, and a central server.This model service has been used in 30 patients with wounds on their lower extremities for 109 times in 1 month. Following a short learning curve, the service worked well and was deemed to be user-friendly. Two (6.7\%) patients had wounds healed, while others still required wound dressing changes after the study finished. Both local surgeons and patients showed good acceptance of this model (100\% and 83.33\%, respectively).This telemedicine model is feasible and valuable because it provides an opportunity of medical service about wound healing in remote areas where specialists are scarce.},
	language = {eng},
	number = {31},
	journal = {Medicine},
	author = {Ye, Junna and Zuo, Yanhai and Xie, Ting and Wu, Minjie and Ni, Pengwen and Kang, Yutian and Yu, Xiaoping and Sun, Xiaofang and Huang, Yao and Lu, Shuliang},
	month = aug,
	year = {2016},
	pmid = {27495023},
	pmcid = {PMC4979777},
	keywords = {Adult, Aged, Aged, 80 and over, China, Eyeglasses, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pilot Projects, Risk Assessment, Smartphone, Telemedicine, Treatment Outcome, Wound Healing, Wounds and Injuries, \_tablet},
	pages = {e4198}
}

@article{marufu_prediction_2016,
	title = {Prediction of 30-day mortality after hip fracture surgery by the {Nottingham} {Hip} {Fracture} {Score} and the {Surgical} {Outcome} {Risk} {Tool}.},
	volume = {71},
	copyright = {(c) 2016 The Association of Anaesthetists of Great Britain and Ireland.},
	issn = {1365-2044 0003-2409},
	doi = {10.1111/anae.13418},
	abstract = {The care of the elderly with hip fractures and their outcomes might be improved with resources targeted by the accurate calculation of risks of mortality and morbidity. We used a multicentre national dataset to evaluate and recalibrate the Nottingham Hip Fracture Score and Surgical Outcome Risk Tool. We split 9,017 hip  fracture cases from the Anaesthesia Sprint Audit of Practice into derivation and  validation data sets and used logistic regression to derive new model co-efficients for death at 30 postoperative days. The area (95\% CI) under the receiver operator characteristic curve of 0.71 (0.67-0.75) indicated acceptable discrimination by the Nottingham Hip Fracture Score and acceptable calibration fit (Hosmer-Lemeshow test), p = 0.23, with a similar discrimination by the Surgical Outcome Risk Tool, 0.70 (0.66-0.74), which was miscalibrated to the observed data, p = 0.001. We recommend that studies test these scores for patients with hip fractures in other countries. We also recommend these models are compared with case-mix adjustment tools used in the UK.},
	language = {eng},
	number = {5},
	journal = {Anaesthesia},
	author = {Marufu, T. C. and White, S. M. and Griffiths, R. and Moonesinghe, S. R. and Moppett, I. K.},
	month = may,
	year = {2016},
	pmid = {26940757},
	keywords = {Aged, Aged, 80 and over, Anesthesia, Calibration, Databases, Factual, Female, Hip Fractures/diagnosis/*mortality/*surgery, Hospital Mortality, Humans, Male, Middle Aged, Orthopedic Procedures/mortality, ROC Curve, Risk Adjustment, Risk Assessment, Treatment Outcome, United Kingdom/epidemiology, care of the elderly, fractured hip, outcomes, peri-operative, postoperative, surgery},
	pages = {515--521},
}

@article{
 title = {Quality of life in older people with dementia: a multilevel study of individual attributes and residential care center characteristics},
 type = {article},
 year = {2015},
 identifiers = {[object Object]},
 keywords = {Aged,Aged, 80 and over,Cross-Sectional Studies,Dementia/epidemiology/psychology,Female,Health Status,Humans,Institutionalization,Male,Middle Aged,Nursing Homes,Quality of Life,Questionnaires,Retrospective Studies,Spain/epidemiology,dementia,multilevel analysis,older adults,residential care centers},
 pages = {104-110},
 volume = {15},
 month = {1},
 publisher = {Japan Geriatrics Society},
 city = {Department "G.F. Ingrassia", Hygiene and Public Health, University of Catania, Catania, Italy; National School of Public Health, Carlos III Institute of Health, Madrid, Spain.},
 id = {35f0e744-a287-3daf-8594-25c38c57ad04},
 created = {2016-08-20T16:52:14.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {CI: (c) 2014; JID: 101135738; OTO: NOTNLM; 2013/12/10 [accepted]; 2014/01/24 [aheadofprint]; ppublish},
 folder_uuids = {f1983289-bfcc-4bbc-aa58-64df97457698},
 private_publication = {false},
 abstract = {AIM: To analyze how the characteristics of institutionalized older people with dementia and residential care centers are associated with the individual's quality of life (QoL). METHODS: Data were collected from a survey carried out on 525 elderly people aged 60 years or older in 14 nursing care homes across Spain. Multilevel linear analysis to assess the differences in QoL level between centers and individuals was carried out. RESULTS: The characteristics of the individuals that were associated with a higher QoL were functional independence, health status and gathering with family, friends or neighbors. In contrast, higher levels of dementia, depression and the length of institutionalization had a negative effect on QoL. In relation to the residential care center characteristics, the availability of geriatricians was associated with higher QoL, compared with those centers with no geriatricians on staff. In addition, public centers (public ownership and publicly-funded residents) were also associated with higher QoL than private/mixed centers. The multilevel analysis showed that the 16.4% of the differences in QoL was related to residence factors. CONCLUSION: These results reflect the importance of the functional, social, mental and residential dimensions in the QoL of older adults with dementia. Actions devoted to improving these key dimensions would contribute to promote the well-being of this vulnerable population.},
 bibtype = {article},
 author = {Marventano, S and Prieto-Flores, M E and Sanz-Barbero, B and Martin-Garcia, S and Fernandez-Mayoralas, G and Rojo-Perez, F and Martinez-Martin, P and Forjaz, M J and Ageing, Spanish Research Group on Quality of Life and},
 journal = {Geriatrics & gerontology international},
 number = {1}
}

Paper  abstract   bibtex   

@article{
 title = {Vaccines for the prevention of seasonal influenza in patients with diabetes: systematic review and meta-analysis},
 type = {article},
 year = {2015},
 identifiers = {[object Object]},
 pages = {53},
 volume = {13},
 websites = {http://www.biomedcentral.com/1741-7015/13/53},
 id = {2cc07ac9-3895-3d7d-840a-282f79e47294},
 created = {2015-09-09T15:56:50.000Z},
 file_attached = {true},
 profile_id = {7a0fec24-6ec6-312f-956e-f210abd2cdb7},
 group_id = {943817ab-6073-3383-a1c5-963a6e7efbea},
 last_modified = {2015-09-14T17:18:41.000Z},
 tags = {VDECGA,VDECICIDFLUREV,VDECL4,VDECVI},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {VDECICIDFLUREV; VDECSG; GA},
 bibtype = {article},
 author = {Remschmidt, Cornelius and Wichmann, Ole and Harder, Thomas},
 journal = {BMC Medicine},
 number = {1}
}

@article{
 title = {Bathing Disability and Bathing Persons with Dementia},
 type = {article},
 year = {2015},
 identifiers = {[object Object]},
 keywords = {Aged,Aged, 80 and over,Alzheimer Disease/nursing,Baths/nursing,Dementia/nursing,Education, Nursing, Continuing,Female,Humans,Male},
 pages = {9-14,22},
 volume = {24},
 city = {United States},
 id = {e18a4c8b-cd5c-3173-83e1-3972ab130701},
 created = {2016-08-20T16:52:28.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {JID: 9300545; ppublish},
 folder_uuids = {06be5eb7-ff2d-415d-a16d-66085b37f653,06271a48-ad48-43cc-b073-52e57f10f5e1},
 private_publication = {false},
 abstract = {Bathing disability, evidence of functional decline, predicts admission to long-term care facilities following acute care hospitalizations. Nurses are challenged to assess bathing disability in hospitalized older persons and those with dementia to support their maximal functional performance and implement diverse bathing strategies.},
 bibtype = {article},
 author = {Wolf, Z R and Czekanski, K E},
 journal = {Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses},
 number = {1}
}

@article{
 title = {A cross-sectional survey to investigate the quality of care in Tuscan (Italy) nursing homes: the structural, process and outcome indicators of nutritional care},
 type = {article},
 year = {2015},
 identifiers = {[object Object]},
 keywords = {Aged,Aged, 80 and over,Cross-Sectional Studies,Female,Humans,Italy,Male,Nursing Homes/standards,Nutrition Assessment,Outcome and Process Assessment (Health Care),Quality Indicators, Health Care/standards,State Medicine,Surveys and Questionnaires},
 pages = {223-225},
 volume = {15},
 month = {6},
 day = {6},
 city = {Department of Health Science, University of Florence, viale GB Morgagni 48, 50134, Florence, Italy. guglielmo.bonaccorsi@unifi.it.; Regional Health Agency of Tuscany, Tuscany, Italy. francesca.collini@ars.toscana.it.; Regional Health Agency of Tuscany, Tu},
 id = {d64bdbb7-59e8-3cb6-8a02-a76d22344e68},
 created = {2016-08-21T22:19:08.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {LR: 20150608; JID: 101088677; OID: NLM: PMC4458040; 2014/10/30 [received]; 2015/05/19 [accepted]; 2015/06/06 [aheadofprint]; epublish},
 folder_uuids = {911ed6ae-9b6c-4b26-b2c0-eb5c080b23de,63a49397-62a3-4051-829d-7112ba34c71e},
 private_publication = {false},
 abstract = {BACKGROUND: Previous studies have investigated process and structure indicators of nutritional care as well as their use in nursing homes (NHs), but the relative weight of these indicators in predicting the risk of malnutrition remains unclear. Aims of the present study are to describe the quality indicators of nutritional care in older residents in a sample of NHs in Tuscany, Italy, and to evaluate the predictors of protein-energy malnutrition risk. METHODS: A cross-sectional survey was conducted in 67 NHs. Information was collected to evaluate quality indicators of nutritional care and the individual risk factors for malnutrition, which was assessed using the Malnutrition Universal Screening Tool. A multilevel model was used to analyse the association between risk and predictors. RESULTS: Out of 2395 participants, 23.7 % were at high, 11 % at medium, and 65.3 % at low risk for malnutrition. Forty-two percent of the NHs had only a personal scale to weigh residents; 88 % did not routinely use a screening test/tool for malnutrition; 60 % used some standardized approach for weight measurement; 43 % did not assess the severity of dysphagia; 12 % were not staffed with dietitians. Patients living in NHs where a chair or platform scale was available had a significantly lower risk of malnutrition (OR = 0.73; 95 % CI = 0.56-0.94). None of the other structural or process quality indicators showed a statistically significant association with malnutrition risk. CONCLUSIONS: Of all the process and structural indicators considered, only the absence of an adequate scale to weigh residents predicted the risk of malnutrition, after adjusting for case mix. These findings prompt the conduction of further investigations on the effectiveness of structural and process indicators that are used to describe quality of nutritional care in NHs.},
 bibtype = {article},
 author = {Bonaccorsi, G and Collini, F and Castagnoli, M and Di Bari, M and Cavallini, M C and Zaffarana, N and Pepe, P and Mugelli, A and Lucenteforte, E and Vannacci, A and Lorini, C},
 journal = {BMC health services research}
}

@article{robinson_effects_2015,
	title = {The {Effects} of {Relaxation} {Before} or {After} {Skin} {Damage} on {Skin} {Barrier} {Recovery}: {A} {Preliminary} {Study}},
	volume = {77},
	issn = {1534-7796},
	shorttitle = {The {Effects} of {Relaxation} {Before} or {After} {Skin} {Damage} on {Skin} {Barrier} {Recovery}},
	doi = {10.1097/PSY.0000000000000222},
	abstract = {OBJECTIVES: Psychological interventions administered before wounding can reduce stress and improve healing. However, in many cases, it would be more practical for interventions to be delivered after wounding. This preliminary study investigated whether a brief relaxation intervention could improve healing when administered either before or after skin damage produced by tape stripping in comparison to a control group.
METHODS: One hundred twenty-one healthy adults were randomized into one of three groups: (a) relaxation prestripping group, (b) relaxation poststripping group, or (c) no relaxation. Participants completed measures of stress, fatigue, relaxation, and pain. Relaxation consisted of listening to 20 minutes of guided relaxation, whereas the control condition was quiet reading for 20 minutes. Skin barrier function was measured using transepidermal water loss at baseline, immediately after tape stripping and 25 minutes later.
RESULTS: Relaxation either before or after tape stripping improved skin barrier recovery compared with the control group (F(2,92) = 3.58, p = .032, partial η = 0.074). Participants who took part in the relaxation intervention were significantly more relaxed and reported greater reductions in pain than the control group did 25 minutes after tape stripping. Perceived stress over the last month was not significantly related to healing.
CONCLUSIONS: This study showed that a relaxation intervention had a beneficial effect on skin barrier recovery regardless of whether the intervention was administered before or after wounding. Future research needs to replicate these findings in other wound types and in clinical settings, and investigate the biological mechanisms involved.},
	language = {eng},
	number = {8},
	journal = {Psychosomatic Medicine},
	author = {Robinson, Hayley and Jarrett, Paul and Broadbent, Elizabeth},
	month = oct,
	year = {2015},
	pmid = {26335334},
	note = {00002 },
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Epidermis, Female, Humans, Male, Middle Aged, Recovery of Function, Relaxation Therapy, Skin Physiological Phenomena, Treatment Outcome, Wounds and Injuries, Young Adult},
	pages = {844--852}
}

@article{
 title = {Methods for managing residents with dysphagia},
 type = {article},
 year = {2015},
 identifiers = {[object Object]},
 keywords = {Aged,Aged, 80 and over,Deglutition Disorders/diagnosis/nursing,Dysphagia,Geriatric Nursing/methods/standards,Homes for the Aged,Humans,Nurse's Role,Nursing Homes,Oral Hygiene/nursing,Practice Guidelines as Topic,nutrition,oral hygiene,patient safety},
 pages = {29-33},
 volume = {27},
 month = {5},
 city = {Cherry Hinton Care Home, Cambridge.},
 id = {4454d68f-6ac3-3e14-9413-bc399db89685},
 created = {2016-08-20T16:52:34.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {JID: 101084156; OTO: NOTNLM; ppublish},
 folder_uuids = {06271a48-ad48-43cc-b073-52e57f10f5e1},
 private_publication = {false},
 abstract = {Nurses working in nursing homes will care for residents who have dysphagia, or difficulty swallowing, on a regular basis. Clear, evidence-based guidelines are necessary for all staff to be able to meet the needs of these residents safely and efficiently. A multidisciplinary approach is important to ensure accurate assessment, devise appropriate care and achieve specific goals. Equipment such as valved beakers, rimmed plates and non-slip mats will help maintain safety during mealtimes. Prescription items, such as fluid thickeners and anticholinergic medication, help to manage the condition and provide comfort during mealtimes and in between. Robust education and training should be in place for all nursing and care staff who care for residents with the condition.},
 bibtype = {article},
 author = {Rudakiewicz, J},
 journal = {Nursing older people},
 number = {4}
}

@article{hippisley-cox_performance_2014,
	title = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice: a validation study},
	volume = {4},
	issn = {2044-6055},
	shorttitle = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice},
	doi = {10.1136/bmjopen-2014-005809},
	abstract = {OBJECTIVES: To validate the performance of a set of risk prediction algorithms developed using the QResearch database, in an independent sample from general practices contributing to the Clinical Research Data Link (CPRD).
SETTING: Prospective open cohort study using practices contributing to the CPRD database and practices contributing to the QResearch database.
PARTICIPANTS: The CPRD validation cohort consisted of 3.3 million patients, aged 25-99 years registered at 357 general practices between 1 Jan 1998 and 31 July 2012. The validation statistics for QResearch were obtained from the original published papers which used a one-third sample of practices separate to those used to derive the score. A cohort from QResearch was used to compare incidence rates and baseline characteristics and consisted of 6.8 million patients from 753 practices registered between 1 Jan 1998 and until 31 July 2013.
OUTCOME MEASURES: Incident events relating to seven different risk prediction scores: QRISK2 (cardiovascular disease); QStroke (ischaemic stroke); QDiabetes (type 2 diabetes); QFracture (osteoporotic fracture and hip fracture); QKidney (moderate and severe kidney failure); QThrombosis (venous thromboembolism); QBleed (intracranial bleed and upper gastrointestinal haemorrhage). Measures of discrimination and calibration were calculated.
RESULTS: Overall, the baseline characteristics of the CPRD and QResearch cohorts were similar though QResearch had higher recording levels for ethnicity and family history. The validation statistics for each of the risk prediction scores were very similar in the CPRD cohort compared with the published results from QResearch validation cohorts. For example, in women, the QDiabetes algorithm explained 50\% of the variation within CPRD compared with 51\% on QResearch and the receiver operator curve value was 0.85 on both databases. The scores were well calibrated in CPRD.
CONCLUSIONS: Each of the algorithms performed practically as well in the external independent CPRD validation cohorts as they had in the original published QResearch validation cohorts.},
	language = {eng},
	number = {8},
	journal = {BMJ open},
	author = {Hippisley-Cox, Julia and Coupland, Carol and Brindle, Peter},
	year = {2014},
	pmid = {25168040},
	pmcid = {PMC4156807},
	keywords = {Adult, Aged, Aged, 80 and over, Algorithms, Calibration, Cardiovascular Diseases, Cprd, Ethnic Groups, Family, Female, General Practice, Hemorrhage, Humans, Kidney Diseases, Male, Middle Aged, Osteoporotic Fractures, Prognosis, Prospective Studies, QResearch, Qrisk2, Risk, Validation, Venous Thromboembolism, diabetes mellitus},
	pages = {e005809}
}

@article{wiwatanadate_acute_2014,
	title = {Acute air pollution-related symptoms among residents in {Chiang} {Mai}, {Thailand}},
	volume = {76},
	issn = {0022-0892},
	abstract = {Open burnings (forest fires, agricultural, and garbage burnings) are the major sources of air pollution in Chiang Mai, Thailand. A time series prospective study was conducted in which 3025 participants were interviewed for 19 acute symptoms with the daily records of ambient air pollutants: particulate matter less than 10 microm in size (PM10), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3). PM10 was positively associated with blurred vision with an adjusted odds ratio (OR) of 1.009. CO was positively associated with lower lung and heart symptoms with adjusted ORs of 1.137 and 1.117. NO2 was positively associated with nosebleed, larynx symptoms, dry cough, lower lung symptoms, heart symptoms, and eye irritation with the range of adjusted ORs (ROAORs) of 1.024 to 1.229. SO2 was positively associated with swelling feet, skin symptoms, eye irritation, red eyes, and blurred vision with ROAORs of 1.205 to 2.948. Conversely, O3 was negatively related to running nose, burning nose, dry cough, body rash, red eyes, and blurred vision with ROAORs of 0.891 to 0.979.},
	language = {eng},
	number = {6},
	journal = {Journal of Environmental Health},
	author = {Wiwatanadate, Phongtape},
	month = feb,
	year = {2014},
	pmid = {24645417},
	note = {00003 },
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Environmental Exposure, Female, Humans, Male, Middle Aged, Odds Ratio, Particulate Matter, Prospective Studies, Respiration Disorders, Thailand, Weather},
	pages = {76--84}
}

@article{
 title = {Living in uncertain times: trajectories to death in residential care homes},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 keywords = {Advance Care Planning/organization & administratio,Aged,Aged, 80 and over,Attitude of Health Personnel,England/epidemiology,Frail Elderly,Health Services Research,Homes for the Aged/organization & administration,Hospitalization,Humans,Nursing Homes,Policy Making,Primary Health Care,Professional-Patient Relations,Prospective Studies,Qualitative Research,Terminal Care/organization & administration,care homes,dying trajectories,end-of-life care,palliative care},
 pages = {e576-83},
 volume = {64},
 month = {9},
 city = {Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge.; International Observatory on End of Life Care, Faculty of Health and Medicine, Lancaster University, Lancaster.; Primary Care Unit, Department of Public },
 id = {5fd4a42e-17f3-3187-820a-582da2218f36},
 created = {2016-08-20T16:52:36.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {CI: (c) British Journal of General Practice 2014; JID: 9005323; OID: NLM: PMC4141615; OTO: NOTNLM; ppublish},
 folder_uuids = {cbf07968-bdea-492d-b4e4-d50a2e1cb62d},
 private_publication = {false},
 abstract = {BACKGROUND: Older people living in care homes often have limited life expectancy. Practitioners and policymakers are increasingly questioning the appropriateness of many acute hospital admissions and the quality of end-of-life care provided in care homes. AIM: To describe care home residents' trajectories to death and care provision in their final weeks of life. DESIGN AND SETTING: Prospective study of residents in six residential care homes in three sociodemographically varied English localities: Hertfordshire, Essex, and Cambridgeshire. METHOD: Case note reviews and interviews with residents, care home staff, and healthcare professionals. RESULTS: Twenty-three out of 121 recruited residents died during the study period. Four trajectories to death were identified: 'anticipated dying' with an identifiable end-of-life care period and death in the care home (n = 9); 'unexpected dying' with death in the care home that was not anticipated and often sudden (n = 3); 'uncertain dying' with a period of diagnostic uncertainty or difficult symptom management leading to hospital admission and inpatient death (n = 7); and 'unpredictable dying' with an unexpected event leading to hospital admission and inpatient death (n = 4). End-of-life care tools were rarely used. Most residents who had had one or more acute hospital admission were still alive at the end of the study. CONCLUSION: For some care home residents there was an identifiable period when they were approaching the end-of-life and planned care was put in place. For others, death came unexpectedly or during a period of considerable uncertainty, with care largely unplanned and reactive to events.},
 bibtype = {article},
 author = {Barclay, S and Froggatt, K and Crang, C and Mathie, E and Handley, M and Iliffe, S and Manthorpe, J and Gage, H and Goodman, C},
 journal = {The British journal of general practice : the journal of the Royal College of General Practitioners},
 number = {626}
}

Paper  bibtex   

@article{cassagnes_l_left_2014,
title = {Left Atrial Volume in Chronic Obstructive Pulmonary Disease},
volume = {29},
issn = {0883-5993},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24463406},
Language = {English},
Journal = {J. Thorac. Imaging},
author = {{Cassagnes L} and {Pontana F} and {Molinari F} and {Faivre JB} and {Santangelo T} and {Algeri E} and {Duhamel A} and {Remy J} and {Remy-Jardin M}},
year = {2014},
keywords = {Adult, Aged, Aged, 80 and over, Atrial Function, Left, Cardiac Volume/physiology*, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive/diagnostic imaging, Pulmonary Disease, Chronic Obstructive/epidemiology, Pulmonary Disease, Chronic Obstructive/physiopathology*, Respiratory Function Tests, Risk Factors, Severity of Illness Index, Smoking/epidemiology, Tomography, X-Ray Computed, Ventricular Dysfunction, Left/epidemiology},
pages = {233-239}
}

@article{fisher_fatal_2014,
	title = {Fatal unintentional non-fire-related carbon monoxide poisoning: {England} and {Wales}, 1979-2012},
	volume = {52},
	issn = {1556-9519},
	shorttitle = {Fatal unintentional non-fire-related carbon monoxide poisoning},
	doi = {10.3109/15563650.2014.887092},
	abstract = {CONTEXT: Unintentional carbon monoxide poisoning remains a significant cause of morbidity and mortality in England and Wales. METHODS.
STUDY DESIGN: observational case series. Data on fatal carbon monoxide poisoning in England and Wales from 1979 to 2012 were obtained from coroner reports. Data on unintentional non-fire-related carbon monoxide poisoning were extracted and were analysed by year of registration of death, sex, age group, and whether death occurred at a private house, flat, associated garage, or residential caravan ('home'), or elsewhere.
RESULTS AND DISCUSSION: There were 28,944 carbon monoxide-related deaths, of which 82\% were male. Deaths increased from 965 (1979) to 1700 (1987), and then fell to 182 (2012). Of these 2208 (64\% male) were recorded as unintentional non-fire-related deaths. Annual numbers of these latter deaths fell from 166 in 1979 to 25 in 2012 (i.e. from 3.37 to 0.44 per million population). Some 81 and 92\% of such deaths in males and in females, respectively, occurred at 'home'. A clear preponderance of male versus female deaths was seen in the 10-19, 20-39 and 40-64 years age groups, with similar numbers of deaths in males and in females in the younger ({\textless} 1 and 1-9 year) and higher (65-79 and 80 + years) age groups. A higher proportion of these excess deaths in males occurred outside the deceased's 'home' in those aged 10-19, 20-39 and 40-64 years.
CONCLUSION: Deaths from unintentional non-fire-related carbon monoxide poisoning are now much less common in England and Wales than in earlier years, but remain a cause for concern. Installation and proper maintenance of carbon monoxide alarms in dwellings and outhouses, for example, and education not only of the public, but also of health and other professionals as to the danger posed by carbon monoxide could help prevent such deaths.},
	language = {eng},
	number = {3},
	journal = {Clinical Toxicology (Philadelphia, Pa.)},
	author = {Fisher, D. S. and Leonardi, G. and Flanagan, R. J.},
	month = mar,
	year = {2014},
	pmid = {24533843},
	note = {00006 },
	keywords = {Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Carbon Monoxide Poisoning, Child, England, Female, Humans, Male, Middle Aged, Sex Characteristics, Time Factors, Wales},
	pages = {166--170}
}

@article{lawlor_nilvad_2014,
	title = {{NILVAD} protocol: a {European} multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate {Alzheimer}'s disease},
	volume = {4},
	issn = {2044-6055},
	shorttitle = {{NILVAD} protocol},
	doi = {10.1136/bmjopen-2014-006364},
	abstract = {INTRODUCTION: This study is a European multicentre, randomised, double-blind, placebo-controlled trial investigating the efficacy and safety of nilvadipine as a disease course modifying treatment for mild-to-moderate Alzheimer's disease (AD) in a phase III study that will run for a period of 82 weeks with a treatment period of 78 weeks.
METHODS AND ANALYSIS: Adult patients, males and females over 50 years with mild-to-moderate AD as defined by the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's disease and Related Disorders Association (NINCDS-ADRDA) criteria, will be included in the study. It aims to recruit a total of 500 patients with AD; 250 in the nilvadipine group and 250 in the placebo group. Participants will be randomised to receive nilvadipine, an 8 mg overencapsulated, sustained release capsule, or a matching overencapsulated placebo (sugar pill) for a period of 78 weeks of treatment. The primary efficacy outcome measure in this study is the change in cognitive function as assessed by the Alzheimer's disease Assessment Scale (ADAS-Cog 12) from baseline to the end of treatment duration (78 weeks). There are two key secondary outcome measures, the Clinical Dementia Rating Scale Sum of Boxes (CDR-sb) and the Disability Assessment for Dementia (DAD). If a statistically significant effect is seen in the primary outcome, CDR-sb will be considered to be a coprimary end point and only the DAD will contribute to the secondary outcome analysis.
ETHICS AND DISSEMINATION: The study and all subsequent amendments have received ethical approval within each participating country according to national regulations. Each participant will provide written consent to participate in the study. All participants will remain anonymised throughout and the results of the study will be published in an international peer-reviewed journal.
TRIAL REGISTRATION NUMBER: EUDRACT Reference Number: 2012-002764-27.},
	language = {eng},
	number = {10},
	journal = {BMJ open},
	author = {Lawlor, Brian and Kennelly, Sean and O'Dwyer, Sarah and Cregg, Fiona and Walsh, Cathal and Coen, Robert and Kenny, Rose Anne and Howard, Robert and Murphy, Caroline and Adams, Jessica and Daly, Leslie and Segurado, Ricardo and Gaynor, Siobhan and Crawford, Fiona and Mullan, Michael and Lucca, Ugo and Banzi, Rita and Pasquier, Florence and Breuilh, Laetitia and Riepe, Matthias and Kalman, Janos and Wallin, Anders and Borjesson, Anne and Molloy, William and Tsolaki, Magda and Olde Rikkert, Marcel},
	month = oct,
	year = {2014},
	pmid = {25300460},
	pmcid = {PMC4194801},
	keywords = {Aged, Alzheimer Disease, Humans, Female, Male, Middle Aged, Europe, Aged, 80 and over, Treatment Outcome, Double-Blind Method, Severity of Illness Index, Calcium Channel Blockers, Nifedipine, GERIATRIC MEDICINE},
	pages = {e006364}
}

Website  abstract   bibtex   

@article{
 title = {Dynamic data during hypotensive episode improves mortality predictions among patients with sepsis and hypotension.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {80 and over,Adult,Aged,Algorithms,Cohort Studies,Comorbidity,Critical Illness,Critical Illness: mortality,Female,Great Britain,Hospital Mortality,Hospital Mortality: trends,Humans,Hypotension,Hypotension: mortality,Intensive Care Units,Male,Middle Aged,Outcome Assessment (Health Care),Predictive Value of Tests,Prognosis,Retrospective Studies,Sepsis,Sepsis: mortality},
 pages = {954-62},
 volume = {41},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3609896&tool=pmcentrez&rendertype=abstract},
 month = {4},
 publisher = {NIH Public Access},
 id = {95d7042f-e668-3f25-aeb3-4f00b98dda28},
 created = {2016-03-29T18:26:56.000Z},
 file_attached = {false},
 profile_id = {304786e8-5116-360a-80be-e62833097578},
 group_id = {d7b44578-07c1-3210-ae74-3bcd7f980767},
 last_modified = {2017-03-14T15:45:25.917Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Mayaud_Crit_Care_April_2013},
 source_type = {article},
 private_publication = {false},
 abstract = {OBJECTIVES: To determine if a prediction rule for hospital mortality using dynamic variables in response to treatment of hypotension in patients with sepsis performs better than current models.\n\nDESIGN: Retrospective cohort study.\n\nSETTING: All ICUs at a tertiary care hospital.\n\nPATIENTS: Adult patients admitted to ICUs between 2001 and 2007 of whom 2,113 met inclusion criteria and had sufficient data.\n\nINTERVENTIONS: None.\n\nMEASUREMENTS AND MAIN RESULTS: We developed a prediction algorithm for hospital mortality in patients with sepsis and hypotension requiring medical intervention using data from the Multiparameter Intelligent Monitoring in Intensive Care II. We extracted 189 candidate variables, including treatments, physiologic variables and laboratory values collected before, during, and after a hypotensive episode. Thirty predictors were identified using a genetic algorithm on a training set (n=1500) and validated with a logistic regression model on an independent validation set (n=613). The final prediction algorithm used included dynamic information and had good discrimination (area under the receiver operating curve=82.0%) and calibration (Hosmer-Lemeshow C statistic=10.43, p=0.06). This model was compared with Acute Physiology and Chronic Health Evaluation IV using reclassification indices and was found to be superior with an Net Reclassification Improvement of 0.19 (p<0.001) and an Integrated Discrimination Improvement of 0.09 (p<0.001).\n\nCONCLUSIONS: Hospital mortality predictions based on dynamic variables surrounding a hypotensive event is a new approach to predicting prognosis. A model using these variables has good discrimination and calibration and offers additional predictive prognostic information beyond established ones.},
 bibtype = {article},
 author = {Mayaud, Louis and Lai, Peggy S and Clifford, Gari D and Tarassenko, Lionel and Celi, Leo Anthony and Annane, Djillali},
 journal = {Critical Care Medicine},
 number = {4}
}

@article{becquemont_national_2013,
	title = {National observatory on the therapeutic management in ambulatory care patients aged 65 and over, with type 2 diabetes, chronic pain or atrial fibrillation},
	volume = {68},
	issn = {0040-5957},
	doi = {10.2515/therapie/2013043},
	abstract = {The primary objective of the S.AGES cohort is to describe the real-life therapeutic care of elderly patients. Patients and methods. This is a prospective observational cohort study of 3 700 non-institutionalized patients over the age of 65 years with either type 2 diabetes mellitus (T2DM), chronic pain or atrial fibrillation (AF) recruited by French general practitioners (GPs). Follow-up is planned for 3 years. Baseline characteristics. In the chronic pain sub-cohort, 33\% of patients are treated with only grade 1 analgesics, 29\% with grade 2 analgesics and 3\% with grade 3 analgesics, and 22\% have no pain treatment. In the T2DM sub-cohort, 61\% of patients have well-controlled diabetes (Hb1c{\textless}7\%) and 18\% are treated with insulin. In the AF sub-cohort, 65\% of patients have a CHADS2 score greater than 2, 77\% are treated with oral anticoagulants, 17\% with platelet inhibitors, 40\% with antiarrhythmic drugs and 56\% with rate slowing medications. Conclusion. The S.AGES cohort presents a unique opportunity to clarify the real-life therapeutic management of ambulatory elderly subjects and will help to identify the factors associated with the occurrence of major clinical events.},
	language = {eng},
	number = {4},
	journal = {Therapie},
	author = {Becquemont, Laurent and Benattar-Zibi, Linda and Bertin, Philippe and Berrut, Gilles and Corruble, Emmanuelle and Danchin, Nicolas and Delespierre, Tiba and Derumeaux, Geneviève and Falissard, Bruno and Forette, Francoise and Hanon, Olivier and Pasquier, Florence and Pinget, Michel and Ourabah, Rissane and Piedvache, Céline and {S.AGES investigators}},
	month = aug,
	year = {2013},
	pmid = {23981265},
	keywords = {Aged, Humans, Female, Male, Aged, 80 and over, Cohort Studies, France, Ambulatory Care, Atrial Fibrillation, Chronic Pain, Diabetes Mellitus, Type 2, Residence Characteristics},
	pages = {265--283}
}

@article{theophile_comparison_2013,
	title = {Comparison of three methods (an updated logistic probabilistic method, the {Naranjo} and {Liverpool} algorithms) for the evaluation of routine pharmacovigilance case reports using consensual expert judgement as reference},
	volume = {36},
	issn = {1179-1942},
	doi = {10.1007/s40264-013-0083-1},
	abstract = {BACKGROUND: An updated probabilistic causality assessment method and the Liverpool algorithm presented as an improved version of the Naranjo algorithm, one of the most used and accepted causality assessment methods, have recently been proposed.
OBJECTIVE: In order to test the validity of the probabilistic method in routine pharmacovigilance, results provided by the Naranjo and Liverpool algorithms, as well as the updated probabilistic method, were each compared with a consensual expert judgement taken as reference.
METHODS: A sample of 59 drug-event pairs randomly sampled from spontaneous reports to the French pharmacovigilance system was assessed by expert judgement until reaching consensus and by members of a pharmacovigilance unit using the updated probabilistic method, the Naranjo and Liverpool algorithms. Probabilities given by the probabilistic method, and categories obtained by both the Naranjo and the Liverpool algorithms were compared as well as their sensitivity, specificity, positive and negative predictive values.
RESULTS: The median probability for drug causation given by the consensual expert judgement was 0.70 (inter-quartile range, IQR 0.54-0.84) versus 0.77 (IQR 0.54-0.91) for the probabilistic method. For the Naranjo algorithm, the 'possible' causality category was predominant (61 \%), followed by 'probable' (35 \%), 'doubtful', and 'almost certain' categories (2 \% each). Category distribution obtained with the Liverpool algorithm was similar to that obtained by the Naranjo algorithm with a majority of 'possible' (61 \%) and 'probable' (30 \%) followed by 'definite' (7 \%) and 'unlikely' (2 \%). For the probabilistic method, sensitivity, specificity, positive and negative predictive values were 0.96, 0.56, 0.92 and 0.71, respectively. For the Naranjo algorithm, depending on whether the 'possible' category was considered in favour or in disfavour of drug causation, sensitivity was, respectively, 1 or 0.42, specificity 0.11 or 0.89, negative predictive value 1 or 0.22 and positive predictive value 0.86 or 0.95; results were identical for the Liverpool algorithm.
CONCLUSION: The logistic probabilistic method gave results closer to the consensual expert judgment than either the Naranjo or Liverpool algorithms whose performance were strongly dependent on the meaning given to the 'possible' category. Owing to its good sensitivity and positive predictive value and by providing results as continuous probabilities, the probabilistic method seems worthy to use for a trustable assessment of adverse drug reactions in routine practice.},
	language = {eng},
	number = {10},
	journal = {Drug Safety},
	author = {Théophile, Hélène and André, Manon and Miremont-Salamé, Ghada and Arimone, Yannick and Bégaud, Bernard},
	month = oct,
	year = {2013},
	pmid = {23828659},
	keywords = {Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Algorithms, Child, Preschool, Consensus, Drug-Related Side Effects and Adverse Reactions, Expert Testimony, Female, France, Humans, Infant, Judgment, Logistic Models, Male, Middle Aged, Pharmaceutical Preparations, Pharmacovigilance, Sensitivity and Specificity},
	pages = {1033--1044}
}

@article{ganten_role_2013,
	title = {The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging},
	volume = {13},
	issn = {1470-7330},
	doi = {10.1102/1470-7330.2013.0045},
	abstract = {PURPOSE: The aim of this study was to characterize and understand the therapy-induced changes in diffusion parameters in rectal carcinoma under chemoradiotherapy (CRT). The current literature shows conflicting results in this regard. We applied the intravoxel incoherent motion model, which allows for the differentiation between diffusion (D) and perfusion (f) effects, to further elucidate potential underlying causes for these divergent reports.
MATERIALS AND METHODS: Eighteen patients with primary rectal carcinoma undergoing preoperative CRT were examined before, during, and after neoadjuvant CRT using diffusion-weighted imaging. Using the intravoxel incoherent motion approach, f and D were extracted and compared with postoperative tumor downstaging and volume.
RESULTS: Initial diffusion-derived parameters were within a narrow range (D1 = 0.94 ± 0.12 × 10(-3) mm(2)/s). At follow-up, D rose significantly (D2 = 1.18 ± 0.13 × 10(-3) mm(2)/s; P {\textless} 0.0001) and continued to increase significantly after CRT (D3 = 1.24 ± 0.14 × 10(-3) mm(2)/s; P {\textless} 0.0001). The perfusion fraction f did not change significantly (f1 = 9.4 ± 2.0\%, f2 = 9.4 ± 1.7\%, f3 = 9.5 ± 2.7\%). Mean volume (V) decreased significantly (V1 = 16,992 ± 13,083 mm(3); V2 = 12,793 ± 8317 mm(3), V3 = 9718 ± 6154 mm(3)). T-downstaging (10:18 patients) showed no significant correlation with diffusion-derived parameters.
CONCLUSIONS: Conflicting results in the literature considering apparent diffusion coefficient (ADC) changes in rectal carcinoma under CRT for patients showing T-downstaging are unlikely to be due to perfusion effects. Our data support the view that under effective therapy, an increase in D/ADC can be observed.},
	language = {eng},
	number = {4},
	journal = {Cancer Imaging: The Official Publication of the International Cancer Imaging Society},
	author = {Ganten, Maria-Katharina and Schuessler, Maximilian and Bäuerle, Tobias and Muenter, Marc and Schlemmer, Heinz-Peter and Jensen, Alexandra and Brand, Karsten and Dueck, Margret and Dinkel, Julien and Kopp-Schneider, Annette and Maier-Hein*, Klaus and Stieltjes, Bram},
	year = {2013},
	keywords = {Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Rectal Neoplasms, Tumor Burden},
	pages = {548--556}
}

Paper  doi  abstract   bibtex   

@article{de_oliveira_socio-demographic_2013,
	title = {Socio-demographic factors and oral health conditions in the elderly: {A} population-based study.},
	volume = {57},
	issn = {0167-4943},
	url = {http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=89884612&site=ehost-live},
	doi = {10.1016/j.archger.2013.05.004},
	abstract = {Abstract: The aim of the present study was to analyze the relationship between oral health conditions and socio-demographic factors in an elderly population from Macaíba/RN (Brazil). A questionnaire was used to characterize the socio-demographic profiles and a clinical examination was performed to assess oral health conditions such as tooth decay, gum disease, use of dental prosthesis, need for dental prosthesis and soft tissue injuries. The technique of random sampling by conglomerates was used, taken from randomly selected census drafts, with a total sample of 441 individuals. The prevalence of edentulism, bleeding and dental calculus was 50.8\%, 27.2\% and 32\%, respectively, excluding all sextants in 59\% of the elderly. Data analysis was conducted using the chi-squared test with the level of significance set at 5\%. Prior to association tests, the dependant variables were submitted to principal component analysis. Four factors were extracted to represent the oral health conditions of elderly individuals. A statistically significant association was found between the following variables: gender and the presence of a caregiver with gum disease; age, residence area, presence of a caregiver and household density with need for dental prosthesis; and household density with soft tissue injuries. Therefore, precarious oral health conditions were found among the elderly and associations were found between these conditions and the socio-demographic factors, particularly gender, age and residence area. The results obtained demonstrated the need for improved oral health conditions in the elderly. The study of these conditions, allied to socio-demographic factors, is important in terms of both dental care and public policy planning related to these individuals.},
	number = {3},
	journal = {Archives of Gerontology \& Geriatrics},
	author = {de Oliveira, Tamires Carneiro and da Silva, Diviane Alves and Leite de Freitas, Yan Nogueira and da Silva, Romerito Lins and Pegado, Carla Patrícia de Castro and de Lima, Kenio Costa},
	month = nov,
	year = {2013},
	note = {Publisher: Elsevier B.V.},
	keywords = {Age Factors, Aged, Aged, 80 and over, Brazil, Brazil/epidemiology, Census, Chi Square Test, Cross-sectional studies, DMF Index, Educational Status, Elderly, Elderly Oral health and socio-demographic conditions Poverty Sampling studies Cross-sectional studies, Elderly people, Female, Gender, Households, Human, Humans, Male, Middle Aged, Oral Health -- Brazil, Oral Health/*statistics \& numerical data, Oral health, Oral health and socio-demographic conditions, Poverty, Prosthesis, Public Policy -- Brazil, Random Sample, Sampling Studies, Sampling studies, Sex Factors, Sociodemographic aspects, Socioeconomic Factors, Socioeconomic Factors -- Brazil, article},
	pages = {389--397},
}

@article{chopra_factors_2013,
	title = {Factors associated with primary hip arthroplasty after hip fracture},
	volume = {19},
	issn = {1936-2692},
	abstract = {OBJECTIVES: To determine patient, clinical, and hospital factors associated with receiving total hip arthroplasty (THA) and hemiarthroplasty (HA) in the United States.
STUDY DESIGN: Retrospective, cross-sectional study.
METHODS: Hospital discharge records with a principal diagnosis of hip fracture and primary hip arthroplasty or no surgery were identified from the 2009 Nationwide Inpatient Sample data set of the Healthcare Cost and Utilization Project. Patient (age, sex, race, income, payer), clinical (comorbidities, severity, fracture type), hospital (region, location, teaching status, bed size, ownership), and outcome (receipt of THA or HA) variables were extracted and weighted for the analyses. Univariate and multivariate analysis were conducted and significance was set at P {\textless} .05.
RESULTS: A total of 92,861, 15,489, and 9863 discharges occurred for HA, no surgery, and THA, respectively. Compared with no surgery, THA or HA was significantly more likely in patients who were aged {\textgreater} 50 years, white, and female; had {\textgreater} \$39,000 income; lived in a medium-metro or noncore county; had comorbidities (anemia, hypertension); and had intracapsular fracture. THA or HA was significantly more likely in urban, privately owned hospitals with {\textgreater} 249 beds. Compared with no surgery, THA was significantly more likely in nonteaching hospitals, the Northeast region, and in private insurance or self-pay patients with moderate to severe fractures; HA was more likely in teaching hospitals, in the South and West, and in Medicare patients with minor fractures.
CONCLUSIONS: Similarities and differences in patient, clinical, and hospital factors associated with surgical treatments of hip fracture warrant the attention of providers and payers.},
	language = {ENG},
	number = {3},
	journal = {The American Journal of Managed Care},
	author = {Chopra, Ishveen and Kamal, Kahlid M. and Sankaranarayanan, Jayashri and Kanyongo, Gibbs},
	month = mar,
	year = {2013},
	keywords = {Age Factors, Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, Comorbidity, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Retrospective Studies, Sex Factors, Socioeconomic Factors, United States, hip fractures},
	pages = {e74--84}
}

@article{
 title = {An environmental scan of an aged care workplace using the PARiHS model: assessing preparedness for change},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Aged, 80 and over,Focus Groups,Homes for the Aged/organization & administration/s,Humans,Models, Theoretical,Organizational Culture,Organizational Innovation,Patient Care Team,Workplace},
 pages = {293-303},
 volume = {21},
 month = {3},
 publisher = {Blackwell Publishing Ltd},
 city = {Research and Development Unit, Helping Hand Aged Inc Care, North Adelaide, South Australia, Australia. hgibb@helpinghand.org.au},
 id = {3a4428f8-5de6-3767-8fb4-6836305e2b86},
 created = {2016-08-21T22:18:08.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {ID: 68477; CI: (c) 2012; JID: 9306050; 2012/06/14 [aheadofprint]; ppublish},
 folder_uuids = {cf78c658-6722-4a88-93c6-6a86fb55df05},
 private_publication = {false},
 abstract = {AIM: The environmental scan aimed to deepen our understanding of the aged care work culture and to ascertain the readiness of the workers to advance towards team-based quality care provision. BACKGROUND: The workplace context was a high-care unit within a large residential aged care facility. METHODS: We used the Promoting Action on Research Implementation in Health Services (PARiHS) framework to assess workplace readiness via interviews, individual surveys and observation of practice. RESULTS: A profile of current culture emerged as mutually supportive and task focused, but at the same time lacking corporate team features of shared decision-making and feedback for practice improvement. However, latent within the frontline leaders and personal care staff, there was evidence of some embedded knowledge and capacity for corporate team performance. CONCLUSIONS: This study has validated an evidence-based method for conducting environmental scanning in aged care, recommended before any major change is introduced. IMPLICATIONS FOR NURSING MANAGEMENT: Environmental scanning helps gauge workforce capacity and limitations; this information can enable managers to capitalize on identified cultural strengths to fortify change and avoid pitfalls of personal and collective vulnerabilities.},
 bibtype = {article},
 author = {Gibb, H},
 journal = {Journal of nursing management},
 number = {2}
}

@article{lapi_androgen_2013,
	title = {Androgen deprivation therapy and risk of acute kidney injury in patients with prostate cancer},
	volume = {310},
	issn = {1538-3598},
	doi = {10.1001/jama.2013.8638},
	abstract = {IMPORTANCE: The use of androgen deprivation therapy (ADT) in the treatment of advanced prostate cancer has been shown to delay the clinical progression of the disease. However, the testosterone suppression associated with this therapy may lead to a hypogonadal condition that can have detrimental effects on renal function, thus raising the hypothesis that ADT-induced hypogonadism could potentially lead to acute kidney injury (AKI).
OBJECTIVE: To determine whether the use of ADT is associated with an increased risk of AKI in patients newly diagnosed with prostate cancer.
DESIGN AND SETTING: A nested case-control analysis using medical information extracted from the UK Clinical Practice Research Datalink linked to the Hospital Episodes Statistics database.
PARTICIPANTS: Men newly diagnosed with nonmetastatic prostate cancer between January 1, 1997, and December 31, 2008, were selected and followed up until December 31, 2009. Cases were patients with incident AKI during follow-up who were randomly matched with up to 20 controls on age, calendar year of prostate cancer diagnosis, and duration of follow-up.
MAIN OUTCOMES AND MEASURES: Conditional logistic regression was used to estimate odds ratios (ORs) with 95\% CIs of AKI associated with the use of ADT. ADT was categorized into 1 of 6 mutually exclusive groups: gonadotropin-releasing hormone agonists, oral antiandrogens, combined androgen blockade, bilateral orchiectomy, estrogens, and combination of the above. RESULTS A total of 10,250 patients met the study inclusion criteria. During a mean follow-up of 4.1 (SD, 2.9) years, 232 incident cases of AKI were identified (rate, 5.5/1000 person-years). Overall, current use of any ADT was associated with an increased risk of AKI when compared with never use (OR, 2.48 [95\% CI, 1.61-3.82]), generating a rate difference of 4.43/1000 persons per year (95\% CI, 1.54-7.33). This association was mainly driven by a combined androgen blockade consisting of gonadotropin-releasing hormone agonists with oral antiandrogens (OR, 4.50 [95\% CI, 2.61-7.78]), estrogens (OR, 4.00 [95\% CI, 1.06-15.03]), other combination therapies (OR, 4.04 [95\% CI, 1.88-8.69]), and gonadotropin-releasing hormone agonists (OR, 1.93 [95\% CI, 1.20-3.10]).
CONCLUSIONS AND RELEVANCE: In a cohort of patients with newly diagnosed nonmetastatic prostate cancer, the use of ADT was significantly associated with an increased risk of AKI. These findings require replication in other well-designed studies as well as further investigation of their clinical importance.},
	language = {eng},
	number = {3},
	journal = {JAMA},
	author = {Lapi, Francesco and Azoulay, Laurent and Niazi, M. Tamim and Yin, Hui and Benayoun, Serge and Suissa, Samy},
	month = jul,
	year = {2013},
	pmid = {23860987},
	keywords = {Acute Kidney Injury, Aged, Aged, 80 and over, Androgen Antagonists, Case-Control Studies, Estrogens, Follow-Up Studies, Gonadotropin-Releasing Hormone, Humans, Male, Odds Ratio, Orchiectomy, Prostatic Neoplasms, Risk},
	pages = {289--296}
}

@article{becker_metformin_2013,
	title = {Metformin and the risk of endometrial cancer: a case-control analysis},
	volume = {129},
	issn = {1095-6859},
	shorttitle = {Metformin and the risk of endometrial cancer},
	doi = {10.1016/j.ygyno.2013.03.009},
	abstract = {OBJECTIVE: To explore the risk of endometrial cancer in relation to metformin and other antidiabetic drugs.
METHODS: We conducted a case-control analysis to explore the association between use of metformin and other antidiabetic drugs and the risk of endometrial cancer using the UK-based General Practice Research Database (GPRD). Cases were women with an incident diagnosis of endometrial cancer, and up to 6 controls per case were matched in age, sex, calendar time, general practice, and number of years of active history in the GPRD prior to the index date. Odds ratios (ORs) with 95\% confidence intervals (95\% CI) were calculated and results were adjusted by multivariate logistic regression analyses for BMI, smoking, a recorded diagnosis of diabetes mellitus, and diabetes duration.
RESULTS: A total of 2554 cases with incident endometrial cancer and 15,324 matched controls were identified. Ever use of metformin compared to never use of metformin was not associated with an altered risk of endometrial cancer (adj. OR 0.86, 95\% CI 0.63-1.18). Stratified by exposure duration, neither long-term (≥25 prescriptions) use of metformin (adj. OR 0.79, 95\% CI 0.54-1.17), nor long-term use of sulfonylureas (adj. OR 0.96, 95\% CI 0.65-1.44), thiazolidinediones (≥15 prescriptions; adj. OR 1.22, 95\% CI 0.67-2.21), or insulin (adj. OR 1.05 (0.79-1.82) was associated with the risk of endometrial cancer.
CONCLUSION: Use of metformin and other antidiabetic drugs were not associated with an altered risk of endometrial cancer.},
	language = {eng},
	number = {3},
	journal = {Gynecologic Oncology},
	author = {Becker, Claudia and Jick, Susan S. and Meier, Christoph R. and Bodmer, Michael},
	month = jun,
	year = {2013},
	pmid = {23523618},
	keywords = {Adult, Aged, Aged, 80 and over, Case-Control Studies, Endometrial Neoplasms, Female, General Practice, Great Britain, Humans, Hypoglycemic Agents, Logistic Models, Metformin, Middle Aged, incidence},
	pages = {565--569}
}

Paper  doi  abstract   bibtex   

@article{hirai_distribution_2012,
	title = {Distribution of polybrominated diphenyl ethers in {Japanese} autopsy tissue and body fluid samples.},
	volume = {19},
	issn = {1614-7499},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22544599},
	doi = {10.1007/s11356-012-0915-z},
	abstract = {Brominated flame retardants are components of many plastics and are used in products such as cars, textiles, televisions, and personal computers. Human exposure to polybrominated diphenyl ether (PBDE) flame retardants has increased exponentially during the last three decades. Our objective was to measure the body burden and distribution of PBDEs and to determine the concentrations of the predominant PBDE congeners in samples of liver, bile, adipose tissue, and blood obtained from Japanese autopsy cases. Tissues and body fluids obtained from 20 autopsy cases were analyzed. The levels of 25 PBDE congeners, ranging from tri- to hexa-BDEs, were assessed. The geometric means of the sum of the concentrations of PBDE congeners having detection frequencies {\textbackslash}textgreater50 \% (ΣPBDE) in the blood, liver, bile, and adipose tissue were 2.4, 2.6, 1.4, and 4.3 ng/g lipid, respectively. The most abundant congeners were BDE-47 and BDE-153, followed by BDE-100, BDE-99, and BDE-28+33. These concentrations of PBDE congeners were similar to other reports of human exposure in Japan but were notably lower than concentrations than those reported in the USA. Significant positive correlations were observed between the concentrations of predominant congeners and ΣPBDE among the samples analyzed. The ΣPBDE concentration was highest in the adipose tissue, but PBDEs were distributed widely among the tissues and body fluids analyzed. The PBDE levels observed in the present study are similar to those reported in previous studies in Japan and significantly lower than those reported in the USA.},
	number = {8},
	journal = {Environmental science and pollution research international},
	author = {Hirai, Tetsuya and Fujimine, Yoshinori and Watanabe, Shaw and Nakano, Takeshi},
	month = sep,
	year = {2012},
	pmid = {22544599},
	keywords = {80 and over, Adipose Tissue, Adipose Tissue: chemistry, Adult, Aged, Asian Continental Ancestry Group, Bile, Bile: chemistry, Body Burden, Cadaver, Female, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Halogenated Diphenyl Ethers: blood, Humans, Liver, Liver: chemistry, Male, Middle Aged},
	pages = {3538--46},
}

@article{looker_lumbar_2012-1,
	title = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: {United} {States}, 2005-2008},
	issn = {0083-1980},
	shorttitle = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area},
	abstract = {OBJECTIVE: This report presents bone measurement data from dual-energy X-ray absorptiometry scans of the lumbar spine and proximal femur for persons aged 8 years and over from the National Health and Nutrition Examination Survey (NHANES) 2005-2008.
METHODS: Means, standard deviations, and selected percentiles were calculated for the proximal femur and lumbar spine (total and subregions) by sex, race and ethnicity, and age. Smoothed mean total lumbar spine and femur neck bone mineral density (BMD) were plotted by age, sex, and race and ethnicity. Multiple regression was used to test for significant interactions and to calculate mean total lumbar spine and femur neck BMD after adjusting for age, sex, and race and ethnicity. Differences by sex, race and ethnicity, and age were summarized by calculating the percent difference in adjusted means.
RESULTS: Among scanned individuals, 11\% lacked total lumbar spine data due to invalid data for one or more lumbar vertebrae, and 4\% had invalid data for the proximal femur. Non-Hispanic black persons had 6\% higher total lumbar spine BMD and 9\%-10\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD and femur neck BMD did not differ between Mexican-American and non-Hispanic white persons in those under age 20. For those aged 20 and over, Mexican-American persons had 4\% lower total lumbar spine BMD but 1\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD was 8\%-17\% higher in females aged 8-15 compared with males of the same age. In the age group 16-49, mean total lumbar spine BMD was similar or slightly higher for females compared with males, but after age 50 it was 60\%-15\% lower for females compared with males. Mean femur neck BMD was 5\%-13\% lower for females than males in all age groups except 12-15.},
	language = {eng},
	number = {251},
	journal = {Vital and Health Statistics. Series 11, Data from the National Health Survey},
	author = {Looker, Anne C. and Borrud, Lori G. and Hughes, Jeffery P. and Fan, Bo and Shepherd, John A. and Melton, L. Joseph},
	month = mar,
	year = {2012},
	pmid = {24261130},
	keywords = {Absorptiometry, Photon, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bone Density, Child, Ethnic Groups, Female, Femur, Humans, Lumbar Vertebrae, Male, Middle Aged, Nutrition Surveys, Regression Analysis, Sex Factors, United States, Young Adult},
	pages = {1--132}
}

@article{spoendlin_study_2012,
	title = {A study on the epidemiology of rosacea in the {U}.{K}},
	volume = {167},
	issn = {1365-2133},
	doi = {10.1111/j.1365-2133.2012.11037.x},
	abstract = {BACKGROUND: Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09\% to 22\%. To our knowledge, incidence rates have not been quantified before.
OBJECTIVES: In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls.
METHODS: Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region.
RESULTS: We identified 60,042 rosacea cases and 60,042 controls (61·5\% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80\% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8\% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95\% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase.
CONCLUSIONS: We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.},
	language = {eng},
	number = {3},
	journal = {The British Journal of Dermatology},
	author = {Spoendlin, J. and Voegel, J. J. and Jick, S. S. and Meier, C. R.},
	month = sep,
	year = {2012},
	pmid = {22564022},
	keywords = {Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Alcohol Drinking, Child, Child, Preschool, Diagnosis, Differential, Epidemiologic Methods, Female, Great Britain, Humans, Infant, Life Style, Male, Middle Aged, Rosacea, Smoking, Young Adult, incidence},
	pages = {598--605}
}

@article{fuchs_icu_2012,
	title = {{ICU} admission characteristics and mortality rates among elderly and very elderly patients},
	volume = {38},
	issn = {1432-1238},
	doi = {10.1007/s00134-012-2629-6},
	abstract = {PURPOSE: The effect of advanced age per se versus severity of chronic and acute diseases on the short- and long-term survival of older patients admitted to the intensive care unit (ICU) remains unclear.
METHODS: Intensive care unit admissions to the surgical ICU and medical ICU of patients older than 65 years were analyzed. Patients were divided into three age groups: 65-74, 75-84, and 85 and above. The primary endpoints were 28-day and 1-year mortality.
RESULTS: The analysis focused on 7,265 patients above the age of 65, representing 45.7 \% of the total ICU population. From the first to third age group there was increased prevalence of heart failure (25.9-40.3 \%), cardiac arrhythmia (24.6-43.5 \%), and valvular heart disease (7.5-15.8 \%). There was reduced prevalence of diabetes complications (7.5-2.4 \%), alcohol abuse (4.1-0.6 \%), chronic obstructive pulmonary disease (COPD) (24.4-17.4 \%), and liver failure (5.0-1.0 \%). Logistic regression analysis adjusted for gender, sequential organ failure assessment, do not resuscitate, and Elixhauser score found that patients from the second and third age group had odds ratios of 1.38 [95 \% confidence interval (CI) 1.19-1.59] and 1.53 (95 \% CI 1.29-1.81) for 28-day mortality as compared with the first age group. Cox regression analysis for 1-year mortality in all populations and in 28-day survivors showed the same trend.
CONCLUSIONS: The proportion of elderly patients from the total ICU population is high. With advancing age, the proportion of various preexisting comorbidities and the primary reason for ICU admission change. Advanced age should be regarded as a significant independent risk factor for mortality, especially for ICU patients older than 75.},
	language = {eng},
	number = {10},
	journal = {Intensive Care Medicine},
	author = {Fuchs, Lior and Chronaki, Catherine E. and Park, Shinhyuk and Novack, Victor and Baumfeld, Yael and Scott, Daniel and McLennan, Stuart and Talmor, Daniel and Celi, Leo},
	month = oct,
	year = {2012},
	pmid = {22797350},
	pmcid = {PMC5718912},
	keywords = {Acute Disease, Aged, Aged, 80 and over, Chronic Disease, Comorbidity, Critical Care, Demography, Female, Hospital Mortality, Hospitalization, Humans, Intensive Care Units, Male, Outcome Assessment (Health Care), Patient Admission, Risk Factors, Survival Analysis},
	pages = {1654--1661}
}

@article{kimura_clinical_2012,
	title = {Clinical characteristics of patients with remitting seronegative symmetrical synovitis with pitting edema compared to patients with pure polymyalgia rheumatica},
	volume = {39},
	issn = {0315-162X},
	doi = {10.3899/jrheum.110558},
	abstract = {OBJECTIVE: To compare clinical features of patients with remitting seronegative symmetrical synovitis with pitting edema (RS3PE) and patients with polymyalgia rheumatica (PMR) and to explore the purported association between RS3PE and malignancy.
METHODS: We did a retrospective chart review of patients with RS3PE and PMR treated in a community-based hospital between January 2000 and December 2009. Outcomes assessed were clinical course of disease and associated malignancies.
RESULTS: We identified 28 patients with RS3PE and 123 with pure PMR. All patients with RS3PE fulfilled PMR criteria as well. Age, comorbidity, erythrocyte sedimentation rate, duration and progression of symptoms, treatment response to initial low-dose steroids, and steroid complication rates were similar in both groups. Patients with RS3PE were more likely to be male (79\% vs 41\%; p = 0.001) and to have a history of smoking (39\% vs 15\%; p = 0.008) and a higher rate of depression (11\% vs 2\%; p = 0.044) at diagnosis. Among those with RS3PE, hip pain was less common (39\% vs 74\%; p = 0.001) than in the PMR group. No patients with RS3PE and 6 patients with pure PMR (4.9\%) developed another rheumatological disease during followup. Seven of 9 patients (78\%) with concurrent cancer presented slightly more frequently with systemic symptoms compared to patients without cancer (48\%; p = 0.098), especially with fatigue (56\% vs 22\%; p = 0.037) and anorexia (33\% vs 9.0\%; p = 0.047). Despite rigorous cancer screening in patients with RS3PE, however, the rate of associated malignancy was not statistically different from that of patients with pure PMR [2 (7\%) vs 7 (6\%), respectively; p = 0.673].
CONCLUSION: Despite evidence that RS3PE is clinically distinct from PMR, we observed characteristics, treatment response, and outcomes like those expected in pure PMR. Compared to patients with pure PMR, patients with RS3PE are more likely to be male, to be depressed, and to smoke. Contrary to earlier studies, no clear association of RS3PE with malignancy was found despite rigorous cancer screening, although clinicians should be aware that patients with concurrent cancer may manifest more systemic signs and symptoms, as well as steroid resistance.},
	language = {eng},
	number = {1},
	journal = {The Journal of Rheumatology},
	author = {Kimura, Makiko and Tokuda, Yasuharu and Oshiawa, Hideto and Yoshida, Kazuki and Utsunomiya, Masako and Kobayashi, Tatsuo and Deshpande, Gautam A. and Matsui, Kazuo and Kishimoto, Mitsumasa},
	month = jan,
	year = {2012},
	pmid = {22174210},
	keywords = {Adrenal Cortex Hormones, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Diagnosis, Differential, Disease Progression, Edema, Female, Humans, Male, Middle Aged, Neoplasms, Polymyalgia Rheumatica, Retrospective Studies, Synovitis},
	pages = {148--153}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Poor 1-year survival in elderly patients undergoing nonelective colorectal resection.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Aged, 80 and over,Colectomy,Colectomy: mortality,Fecal Incontinence,Fecal Incontinence: etiology,Female,Follow-Up Studies,Germany,Hospitals, Community,Humans,Male,Middle Aged,Postoperative Complications,Rectal Fistula,Rectal Fistula: mortality,Rectal Fistula: surgery,Reoperation,Retrospective Studies,Survival Rate,Treatment Outcome,Young Adult},
 pages = {788-96},
 volume = {55},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22706132},
 month = {7},
 id = {44cbf07f-e611-36ee-9a91-0db0119c9971},
 created = {2014-10-14T09:23:25.000Z},
 accessed = {2014-10-13},
 file_attached = {true},
 profile_id = {341834ae-df6e-3305-9ea5-95d94ce15292},
 group_id = {62784a9e-1455-39bf-ae63-5ef2a147689e},
 last_modified = {2017-03-14T15:15:44.505Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 abstract = {BACKGROUND: Colorectal resection in elderly patients is associated with significant morbidity and mortality, especially in an emergency setting.

OBJECTIVES: This study aims to quantify the risks associated with nonelective colorectal resection up to 1 year after surgery in elderly patients.

DESIGN: This is a population-based observational study.

SETTING: Data were obtained from the Hospital Episode Statistics database.

POPULATION: All patients aged 70 years and older who underwent a nonelective colorectal resection in an English National Health Service Trust hospital between April 2001 and March 2008 were included.

MAIN OUTCOME MEASURES: : The primary outcomes measured were 30-day in hospital mortality, 365-day mortality, unplanned readmission within 28 days of discharge, and duration of hospital stay.

RESULTS: During the study period, 36,767 nonelective colorectal resections were performed in patients aged ≥ 70 years in England. Patients were classified into 3 age groups: A (70-75 years), B (76-80 years), and C (>80 years). Thirty-day mortality was 17.0%, 23.3%, and 31.0% in groups A, B, and C (p < 0.001). The overall 30-day medical complication rate was 33.7%, and the reoperation rate was 6.3%. Cardiac and respiratory complications were significantly higher in group C (22.2% and 18.2%, p < 0.001). Mortality in Group C was 51.2% at 1-year postsurgery. Advanced age was an independent determinant of mortality in risk-adjusted regression analyses.

LIMITATIONS: This is a retrospective analysis of a prospective database. Stage of disease at presentation, severity of complications, and cause of death cannot be ascertained from this database.

CONCLUSIONS: In this population-based study, half of all English patients aged over 80 years undergoing nonelective colorectal resection died within 1 year of surgery. Further research is required to identify perioperative and postdischarge strategies that may improve survival in this vulnerable cohort.},
 bibtype = {article},
 author = {Mamidanna, Ravikrishna and Eid-Arimoku, Lola and Almoudaris, Alex M and Burns, Elaine M and Bottle, Alex and Aylin, Paul and Hanna, George B and Faiz, Omar},
 journal = {Diseases of the colon and rectum},
 number = {7}
}

@article{ mcelhaney_influenza_2011,
  title = {Influenza vaccine responses in older adults},
  volume = {10},
  issn = {1872-9649},
  doi = {10.1016/j.arr.2010.10.008},
  abstract = {The most profound consequences of immune senescence with respect to public health are the increased susceptibility to influenza and loss of efficacy of the current split-virus influenza vaccines in older adults, which are otherwise very effective in younger populations. Influenza infection is associated with high rates of complicated illness including pneumonia, heart attacks and strokes in the 65+ population. Changes in both innate and adaptive immune function not only converge in the reduced response to vaccination and protection against influenza, but present significant challenges to new vaccine development. In older adults, the goal of vaccination is more realistically targeted to providing clinical protection against disease rather sterilizing immunity. Correlates of clinical protection may not be measured using standard techniques such as antibody titres to predict vaccine efficacy. Further, antibody responses to vaccination as a correlate of protection may fail to detect important changes in cellular immunity and enhanced vaccine-mediated protection against influenza illness in older people. This article will discuss the impact of influenza in older adults, immunologic targets for improved efficacy of the vaccines, and alternative correlates of clinical protection against influenza that are needed for more effective translation of novel vaccination strategies to improved protection against influenza in older adults.},
  language = {eng},
  number = {3},
  journal = {Ageing Research Reviews},
  author = {McElhaney, Janet E.},
  month = {July},
  year = {2011},
  pmid = {21055484},
  pmcid = {PMC3061971},
  keywords = {Adaptive Immunity, Aged, Aged, 80 and over, Aging, Humans, Immunity, Innate, Influenza Vaccines, Influenza, Human, T-Lymphocytes, Treatment Outcome},
  pages = {379--388}
}

@article{hollingworth_common_2011,
	title = {Common variants at {ABCA7}, {MS4A6A}/{MS4A4E}, {EPHA1}, {CD33} and {CD2AP} are associated with {Alzheimer}'s disease},
	volume = {43},
	issn = {1546-1718},
	doi = {10.1038/ng.803},
	abstract = {We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).},
	language = {eng},
	number = {5},
	journal = {Nature Genetics},
	author = {Hollingworth, Paul and Harold, Denise and Sims, Rebecca and Gerrish, Amy and Lambert, Jean-Charles and Carrasquillo, Minerva M. and Abraham, Richard and Hamshere, Marian L. and Pahwa, Jaspreet Singh and Moskvina, Valentina and Dowzell, Kimberley and Jones, Nicola and Stretton, Alexandra and Thomas, Charlene and Richards, Alex and Ivanov, Dobril and Widdowson, Caroline and Chapman, Jade and Lovestone, Simon and Powell, John and Proitsi, Petroula and Lupton, Michelle K. and Brayne, Carol and Rubinsztein, David C. and Gill, Michael and Lawlor, Brian and Lynch, Aoibhinn and Brown, Kristelle S. and Passmore, Peter A. and Craig, David and McGuinness, Bernadette and Todd, Stephen and Holmes, Clive and Mann, David and Smith, A. David and Beaumont, Helen and Warden, Donald and Wilcock, Gordon and Love, Seth and Kehoe, Patrick G. and Hooper, Nigel M. and Vardy, Emma R. L. C. and Hardy, John and Mead, Simon and Fox, Nick C. and Rossor, Martin and Collinge, John and Maier, Wolfgang and Jessen, Frank and Rüther, Eckart and Schürmann, Britta and Heun, Reiner and Kölsch, Heike and van den Bussche, Hendrik and Heuser, Isabella and Kornhuber, Johannes and Wiltfang, Jens and Dichgans, Martin and Frölich, Lutz and Hampel, Harald and Gallacher, John and Hüll, Michael and Rujescu, Dan and Giegling, Ina and Goate, Alison M. and Kauwe, John S. K. and Cruchaga, Carlos and Nowotny, Petra and Morris, John C. and Mayo, Kevin and Sleegers, Kristel and Bettens, Karolien and Engelborghs, Sebastiaan and De Deyn, Peter P. and Van Broeckhoven, Christine and Livingston, Gill and Bass, Nicholas J. and Gurling, Hugh and McQuillin, Andrew and Gwilliam, Rhian and Deloukas, Panagiotis and Al-Chalabi, Ammar and Shaw, Christopher E. and Tsolaki, Magda and Singleton, Andrew B. and Guerreiro, Rita and Mühleisen, Thomas W. and Nöthen, Markus M. and Moebus, Susanne and Jöckel, Karl-Heinz and Klopp, Norman and Wichmann, H.-Erich and Pankratz, V. Shane and Sando, Sigrid B. and Aasly, Jan O. and Barcikowska, Maria and Wszolek, Zbigniew K. and Dickson, Dennis W. and Graff-Radford, Neill R. and Petersen, Ronald C. and {Alzheimer's Disease Neuroimaging Initiative} and van Duijn, Cornelia M. and Breteler, Monique M. B. and Ikram, M. Arfan and DeStefano, Anita L. and Fitzpatrick, Annette L. and Lopez, Oscar and Launer, Lenore J. and Seshadri, Sudha and {CHARGE consortium} and Berr, Claudine and Campion, Dominique and Epelbaum, Jacques and Dartigues, Jean-François and Tzourio, Christophe and Alpérovitch, Annick and Lathrop, Mark and {EADI1 consortium} and Feulner, Thomas M. and Friedrich, Patricia and Riehle, Caterina and Krawczak, Michael and Schreiber, Stefan and Mayhaus, Manuel and Nicolhaus, S. and Wagenpfeil, Stefan and Steinberg, Stacy and Stefansson, Hreinn and Stefansson, Kari and Snaedal, Jon and Björnsson, Sigurbjörn and Jonsson, Palmi V. and Chouraki, Vincent and Genier-Boley, Benjamin and Hiltunen, Mikko and Soininen, Hilkka and Combarros, Onofre and Zelenika, Diana and Delepine, Marc and Bullido, Maria J. and Pasquier, Florence and Mateo, Ignacio and Frank-Garcia, Ana and Porcellini, Elisa and Hanon, Olivier and Coto, Eliecer and Alvarez, Victoria and Bosco, Paolo and Siciliano, Gabriele and Mancuso, Michelangelo and Panza, Francesco and Solfrizzi, Vincenzo and Nacmias, Benedetta and Sorbi, Sandro and Bossù, Paola and Piccardi, Paola and Arosio, Beatrice and Annoni, Giorgio and Seripa, Davide and Pilotto, Alberto and Scarpini, Elio and Galimberti, Daniela and Brice, Alexis and Hannequin, Didier and Licastro, Federico and Jones, Lesley and Holmans, Peter A. and Jonsson, Thorlakur and Riemenschneider, Matthias and Morgan, Kevin and Younkin, Steven G. and Owen, Michael J. and O'Donovan, Michael and Amouyel, Philippe and Williams, Julie},
	month = may,
	year = {2011},
	pmid = {21460840},
	pmcid = {PMC3084173},
	keywords = {Aged, Alzheimer Disease, Humans, Female, Male, Aged, 80 and over, Genetic Predisposition to Disease, Case-Control Studies, Genome-Wide Association Study, Adaptor Proteins, Signal Transducing, Polymorphism, Single Nucleotide, Antigens, CD, Antigens, Differentiation, Myelomonocytic, ATP-Binding Cassette Transporters, Cytoskeletal Proteins, Databases, Genetic, Genetic Variation, Membrane Proteins, Multigene Family, Receptor, EphA1, Sialic Acid Binding Ig-like Lectin 3},
	pages = {429--435}
}

@article{humes_concurrent_2011,
	title = {Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study},
	volume = {60},
	issn = {1468-3288},
	shorttitle = {Concurrent drug use and the risk of perforated colonic diverticular disease},
	doi = {10.1136/gut.2010.217281},
	abstract = {OBJECTIVE: To determine the risk of diverticular perforation associated with current and ever use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists.
DESIGN, SETTING AND PARTICIPANTS: Case-control analysis using conditional logistic regression analysis of data from the UK General Practice Research Database. The study involved 899 cases of incident diverticular perforation and 8980 population controls from 1990 to 2005.
MAIN OUTCOME MEASURES: Odds ratios (ORs) are presented for perforation associated with use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists. Data were adjusted for smoking, comorbidity, prior abdominal pain and body mass index.
RESULTS: A total of 899 patients with an incident diagnosis of perforated diverticular disease were identified. Current use of opiate analgesics (OR=2.16; 95\% CI 1.55 to 3.01) and oral corticosteroids (OR=2.74; 95\% CI 1.63 to 4.61) was associated with a two- and threefold increase in the risk of diverticular perforation, respectively. Current use of a calcium antagonist and aspirin were not associated with an increased risk of diverticular perforation. Current statin use was associated with a reduction in the risk of perforation (OR=0.44; 95\% CI 0.20 to 0.95).
CONCLUSION: Perforated diverticular disease is a serious surgical emergency with current opiate analgesics and oral corticosteroids being strongly associated with an increased risk of diverticular perforation.},
	language = {eng},
	number = {2},
	journal = {Gut},
	author = {Humes, David J. and Fleming, Kate M. and Spiller, Robin C. and West, Joe},
	month = feb,
	year = {2011},
	pmid = {20940283},
	keywords = {Aged, Aged, 80 and over, Analgesics, Anti-Inflammatory Agents, Non-Steroidal, Cardiovascular Agents, Comorbidity, Confounding Factors (Epidemiology), Diverticulum, Colon, Drug-Related Side Effects and Adverse Reactions, Epidemiologic Methods, Female, Glucocorticoids, Great Britain, Humans, Intestinal Perforation, Male, Middle Aged},
	pages = {219--224}
}

Paper  doi  abstract   bibtex   

@article{gow_stability_2011,
	title = {Stability and change in intelligence from age 11 to ages 70, 79, and 87: the {Lothian} {Birth} {Cohorts} of 1921 and 1936.},
	volume = {26},
	issn = {1939-1498},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/20973608},
	doi = {10.1037/a0021072},
	abstract = {Investigating the predictors of age-related cognitive change is a research priority. However, it is first necessary to discover the long-term stability of measures of cognitive ability because prior cognitive ability level might contribute to the amount of cognitive change experienced within old age. These two issues were examined in the Lothian Birth Cohorts of 1921 and 1936. Cognitive ability data were available from age 11 years when the participants completed the Moray House Test No. 12 (MHT). The Lothian Birth Cohort 1936 (LBC1936) completed the MHT a second time at age 70. The Lothian Birth Cohort 1921 (LBC1921) completed the MHT at ages 79 and 87. We examined cognitive stability and change from childhood to old age in both cohorts, and within old age in the LBC1921. Raw stability coefficients for the MHT from 11-70, 11-79, and 11-87 years were .67, .66, and .51, respectively; and larger when corrected for range restriction in the samples. Therefore, minimum estimates of the variance in later-life MHT accounted for by childhood performance on the same test ranged from 26-44\%. This study also examined, in the LBC1921, whether MHT score at age 11 influenced the amount of change in MHT between ages 79 and 87. It did not. Higher intelligence from early life was apparently protective of intelligence in old age due to the stability of cognitive function across the lifespan, rather than because it slowed the decline experienced in later life.},
	number = {1},
	urldate = {2012-07-23},
	journal = {Psychology and aging},
	author = {Gow, Alan J and Johnson, Wendy and Pattie, Alison and Brett, Caroline E and Roberts, Beverly and Starr, John M and Deary, Ian J},
	month = mar,
	year = {2011},
	pmid = {20973608},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Aging, Aging: physiology, Aging: psychology, Child, Cognition, Cognition: physiology, Female, Humans, Intelligence, Intelligence Tests, Intelligence: physiology, Longitudinal Studies, Male, Middle Aged, Scotland, Young Adult},
	pages = {232--40},
}

@article{filion_thiazolidinediones_2011,
	title = {Thiazolidinediones and the risk of incident congestive heart failure among patients with type 2 diabetes mellitus},
	volume = {20},
	issn = {1099-1557},
	doi = {10.1002/pds.2165},
	abstract = {BACKGROUND: Clinical trials suggest that thiazolidinediones (TZDs) may increase the risk of congestive heart failure (CHF). However, their effect on the risk of incident CHF in unselected populations has not been thoroughly investigated.
METHODS: Using data from the UK's General Practice Research Database, we conducted a case-control study within a population-based cohort of patients with type 2 diabetes. Cases were identified by a clinical diagnosis of incident CHF and were then classified as possible or probable cases using prescription data. A 90-day drug exposure window was used in the primary analysis, which compared patients prescribed TZDs with those with no prescriptions for anti-diabetic medications.
RESULTS: We identified 3405 incident cases (2632 probable and 773 possible) of CHF and 32,042 corresponding controls. TZDs were prescribed in 6.4\% of cases and 6.3\% of controls. Prescription of TZDs was associated with an increased rate of possible or probable CHF (adjusted rate ratio (RR) = 1.24, 95\% CI = 1.01, 1.54 and adjusted RR = 1.24, 95\% CI = 0.98, 1.58, respectively). Similar results were obtained when using a 180-day exposure window (RR = 1.38, 95\% CI = 1.11, 1.72 and RR = 1.44, 95\% CI = 1.12, 1.84, respectively).
CONCLUSIONS: Given the totality of the evidence from this and previous studies, the probability of an increased risk for CHF with these agents remains high. However, any increase in CHF risk associated with TZDs may be lower than previously reported.},
	language = {eng},
	number = {8},
	journal = {Pharmacoepidemiology and Drug Safety},
	author = {Filion, Kristian B. and Joseph, Lawrence and Boivin, Jean-François and Suissa, Samy and Brophy, James M.},
	month = aug,
	year = {2011},
	pmid = {21671441},
	keywords = {Aged, Aged, 80 and over, Case-Control Studies, Databases, Factual, Diabetes Mellitus, Type 2, Female, Great Britain, Heart Failure, Humans, Hypoglycemic Agents, Male, Middle Aged, Risk, Thiazolidinediones},
	pages = {785--796}
}

@article{vinogradova_exposure_2011,
	title = {Exposure to cyclooxygenase-2 inhibitors and risk of cancer: nested case-control studies},
	volume = {105},
	issn = {1532-1827},
	shorttitle = {Exposure to cyclooxygenase-2 inhibitors and risk of cancer},
	doi = {10.1038/bjc.2011.252},
	abstract = {BACKGROUND: Selective cyclooxygenase-2 (COX2) inhibitors are widely used as analgesics and it is unclear whether its long-term use affects cancer risk.
METHODS: A series of nested case-control studies using the QResearch primary care database. Associations of COX2 inhibitor use with risk of all cancers and 10 common site-specific cancers were estimated using conditional logistic regression adjusted for comorbidities, smoking status, socioeconomic status, and use of non-steroidal anti-inflammatory drugs, aspirin and statins.
RESULTS: A total of 88,125 cancers, diagnosed between 1998 and 2008, matched with up to five controls, were analysed. Use of COX2 inhibitors for more than a year was associated with a significantly increased risk of breast cancer (odds ratio (OR) 1.24, 95\% confidence interval (CI) 1.08-1.42) and haematological malignancies (OR 1.38, 95\% CI 1.12-1.69) and a decreased risk of colorectal cancer (OR 0.76, 95\% CI 0.63-0.92). There were no other significant associations.
CONCLUSION: Prolonged use of COX2 inhibitors was associated with an increased risk of breast and haematological cancers and decreased risk of colorectal cancer. These findings need to be confirmed using other data sources.},
	language = {eng},
	number = {3},
	journal = {British Journal of Cancer},
	author = {Vinogradova, Y. and Coupland, C. and Hippisley-Cox, J.},
	month = jul,
	year = {2011},
	pmid = {21750557},
	pmcid = {PMC3172909},
	keywords = {Adult, Aged, Aged, 80 and over, Breast Neoplasms, Case-Control Studies, Colorectal Neoplasms, Cyclooxygenase 2 Inhibitors, Drug Administration Schedule, Female, Hematologic Neoplasms, Humans, Male, Middle Aged, Neoplasms, Risk Factors},
	pages = {452--459}
}

@article{deramecourt_88-year_2011,
	title = {An 88-year old woman with long-lasting parkinsonism},
	volume = {21},
	issn = {1750-3639},
	doi = {10.1111/j.1750-3639.2011.00496.x},
	language = {eng},
	number = {4},
	journal = {Brain Pathology (Zurich, Switzerland)},
	author = {Deramecourt, Vincent and Maurage, Claude-Alain and Sergeant, Nicolas and Buée-Scherrer, Valérie and Buée, Luc and Defebvre, Luc},
	month = jul,
	year = {2011},
	pmid = {21668554},
	keywords = {Aged, Humans, Female, Middle Aged, Brain, Adult, Disease Progression, Aged, 80 and over, Adolescent, Child, Child, Preschool, Infant, Parkinson Disease, Postencephalitic},
	pages = {465--468}
}

@article{kuy_age_2011,
	title = {Age matters: a study of clinical and economic outcomes following cholecystectomy in elderly {Americans}},
	volume = {201},
	issn = {1879-1883},
	shorttitle = {Age matters},
	doi = {10.1016/j.amjsurg.2010.04.018},
	abstract = {BACKGROUND: Gallstone disease increases with age. The aims of this study were to measure short-term outcomes from cholecystectomy in hospitalized elderly patients, assess the effect of age, and identify predictors of outcomes.
METHODS: This was a cross-sectional analysis, using the Health Care Utilization Project Nationwide Inpatient Sample (1999-2006), of elderly patients (aged 65-79 and ≥80 years) and a comparison group (aged 50-64 years) hospitalized for cholecystectomy. Linear and logistic regression models were used to evaluate age and outcome relationships. Main outcomes were in-hospital mortality, complications, discharge disposition, mean length of stay, and cost.
RESULTS: A total of 149,855 patients aged 65 to 79 years, 62,561 patients aged ≥ 80 years, and 145,675 subjects aged 50 to 64 years were included. Elderly patients had multiple biliary diagnoses and longer times to surgery from admission and underwent more open procedures. Patients aged 65 to 79 years and those aged ≥80 years had higher adjusted odds of mortality (odds ratios [ORs], 2.36 and 5.91, respectively), complications (ORs, 1.57 and 2.39), nonroutine discharge (ORs, 3.02 and 10.76), longer length of stay (ORs, 1.11 and 1.31), and higher cost (ORs, 1.09 and 1.22) than younger patients.
CONCLUSIONS: Elderly patients undergoing inpatient cholecystectomy have complex disease, with worse outcomes. Longer time from admission to surgery predicts poor outcome.},
	language = {ENG},
	number = {6},
	journal = {American Journal of Surgery},
	author = {Kuy, Sreyram and Sosa, Julie Ann and Roman, Sanziana A. and Desai, Rani and Rosenthal, Ronnie A.},
	month = jun,
	year = {2011},
	keywords = {Aged, Aged, 80 and over, Cholecystectomy, Cost of Illness, Cross-Sectional Studies, Female, Follow-Up Studies, Gallbladder Diseases, Hospital Mortality, Humans, Male, Middle Aged, Retrospective Studies, Survival Rate, United States},
	pages = {789--796}
}

@article{hippisley-cox_individualising_2010,
	title = {Individualising the risks of statins in men and women in {England} and {Wales}: population-based cohort study},
	volume = {96},
	issn = {1468-201X},
	shorttitle = {Individualising the risks of statins in men and women in {England} and {Wales}},
	doi = {10.1136/hrt.2010.199034},
	abstract = {OBJECTIVE: To derive and validate risk algorithms so that the risks of four clinical outcomes associated with statin use can be estimated for individual patients.
DESIGN: Prospective open cohort study using routinely collected data from 368 QResearch general practices in England and Wales to develop the scores. The scores were validated using two separate sets of practices-188 separate QResearch practices and 364 practices contributing to the THIN database.
SUBJECTS: In the QResearch derivation cohort 225 922 new users of statins and 1 778 770 non-users of statins were studied. In the QResearch validation cohort 118 372 statin users and 877 812 non-users of statins were studied. In the THIN validation cohort, we studied 282 056 statin users and 1 923 840 non-users of statins were studied.
METHODS: Cox proportional hazards models in the derivation cohort to derive risk equations. Measures of calibration and discrimination in both validation cohorts.
OUTCOMES: 5-Year risk of moderate/serious myopathic events; moderate/serious liver dysfunction; acute renal failure and cataract.
RESULTS: The performance of three of the risk prediction algorithms in the THIN cohort was very good. For example, in women, the algorithm for moderate/serious myopathy explained 42.15\% of the variation. The corresponding D statistics was 1.75. The acute renal failure algorithm explained 59.62\% of the variation (D statistic=2.49). The cataract algorithm explained 59.14\% of the variation (D statistic=2.46). The algorithms to predict moderate/severe liver dysfunction only explained 15.55\% of the variation (D statistics=0.89). The performance of each algorithm was similar for both sexes when tested on the QResearch validation cohort.
CONCLUSIONS: The algorithms to predict acute renal failure, moderate/serious myopathy and cataract could be used to identify patients at increased risk of these adverse effects enabling patients to be monitored more closely. Further research is needed to develop a better algorithm to predict liver dysfunction.},
	language = {eng},
	number = {12},
	journal = {Heart (British Cardiac Society)},
	author = {Hippisley-Cox, Julia and Coupland, Carol},
	month = jun,
	year = {2010},
	pmid = {20489220},
	keywords = {Acute Kidney Injury, Adult, Aged, Aged, 80 and over, Algorithms, Body Mass Index, Cataract, Drug-Induced Liver Injury, England, Epidemiologic Methods, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Muscular Diseases, Wales},
	pages = {939--947}
}

@article{hansmannel_is_2010,
	title = {Is the urea cycle involved in {Alzheimer}'s disease?},
	volume = {21},
	issn = {1875-8908},
	doi = {10.3233/JAD-2010-100630},
	abstract = {Since previous observations indicated that the urea cycle may have a role in the Alzheimer's disease (AD) process, we set out to quantify the expression of each gene involved in the urea cycle in control and AD brains and establish whether these genes could be genetic determinants of AD. We first confirmed that all the urea cycle enzyme genes are expressed in the AD brain. The expression of arginase 2 was greater in the AD brain than in the control brain. The presence of the rare arginase 2 allele rs742869 was associated with an increase in the risk of AD in men and with an earlier age-at-onset for both genders. None of the other genes in the pathway appeared to be differentially expressed in the AD brain or act as genetic determinants of the disease.},
	language = {eng},
	number = {3},
	journal = {Journal of Alzheimer's disease: JAD},
	author = {Hansmannel, Franck and Sillaire, Adeline and Kamboh, M. Ilyas and Lendon, Corinne and Pasquier, Florence and Hannequin, Didier and Laumet, Geoffroy and Mounier, Anais and Ayral, Anne-Marie and DeKosky, Steven T. and Hauw, Jean-Jacques and Berr, Claudine and Mann, David and Amouyel, Philippe and Campion, Dominique and Lambert, Jean-Charles},
	year = {2010},
	pmid = {20693631},
	pmcid = {PMC2945690},
	keywords = {Aged, Alzheimer Disease, Humans, Female, Male, Middle Aged, Brain, Aged, 80 and over, Chi-Square Distribution, Risk Factors, Alleles, Genotype, Case-Control Studies, Genetic Association Studies, Arginase, Urea},
	pages = {1013--1021}
}

@article{fan_does_2010,
	title = {Does standardized {BMD} still remove differences between {Hologic} and {GE}-{Lunar} state-of-the-art {DXA} systems?},
	volume = {21},
	issn = {1433-2965},
	doi = {10.1007/s00198-009-1062-3},
	abstract = {The standardized bone mineral density (sBMD) values, derived using universal standardized equations, were shown to be equivalent within 1.0\% for hip but significantly different for spine for state-of-art fan-beam dual X-ray absorptiometry (DXA) Hologic and GE-Lunar systems. Spine L1-L4 and L2-L4 sBMD mean differences between the two systems were 0.042 g/cm(2) (4.1\%) and 0.035 g/cm(2) (3.2\%), respectively.
INTRODUCTION: The objective of this study is to validate the 1994 pencil-beam DXA "universal standardization equations" for state-of-the-art fan-beam DXA systems.
METHODS: The spine and bilateral femurs of 87 postmenopausal women were scanned on both Hologic Delphi and GE-Lunar Prodigy DXA systems at three different clinical centers. The scans were analyzed using Hologic Apex and GE-Lunar EnCore software. The BMD results were converted to sBMD using the equations previously developed. Linear regression analysis was used to describe the relationship of the two systems' BMD results. Bland-Altman analysis was used to assess the differences in measures.
RESULTS: The Apex and Prodigy sBMD values were highly correlated (r ranged from 0.92 to 0.98). Spine L1-L4 and L2-L4 sBMD values had significant intercepts and slopes for Bland-Altman regression, with mean differences of 0.042 g/cm(2) (4.1\%) and 0.035 g/cm(2) (3.2\%), respectively. The total hip and neck sBMD showed no significant intercept and slope, except left total sBMD had a significant difference between the two systems of 0.009 g/cm(2) (1.0\%).
CONCLUSIONS: The sBMD values were shown to be equivalent within 1.0\% for hip but were significantly different for spine on the two systems. Biases may persist in pooled sBMD data from different manufacturers, and further study is necessary to determine the cause.},
	language = {eng},
	number = {7},
	journal = {Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA},
	author = {Fan, B. and Lu, Y. and Genant, H. and Fuerst, T. and Shepherd, J.},
	month = jul,
	year = {2010},
	pmid = {19859644},
	pmcid = {PMC2906746},
	keywords = {Absorptiometry, Photon, Aged, Aged, 80 and over, Bone Density, Female, Femur Neck, Hip Joint, Humans, Lumbar Vertebrae, Middle Aged, Reproducibility of Results},
	pages = {1227--1236}
}

Paper  doi  bibtex   

@article{delahunt_gleason_2010,
	title = {Gleason scoring: a comparison of classical and modified ({International} {Society} of {Urological} {Pathology}) criteria using nadir {PSA} as a clinical end point},
	volume = {42},
	issn = {0031-3025},
	shorttitle = {Pathology},
	url = {http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=01268031-201042040-00006},
	doi = {10.3109/00313021003787924},
	urldate = {2011-11-02},
	journal = {Pathology},
	author = {Delahunt, Brett and Lamb, David S. and Srigley, John R. and Murray, Judy D. and Wilcox, Chantelle and Samaratunga, Hemamali and Atkinson, Christopher and Spry, Nigel A. and Joseph, David and Denham, James W.},
	month = jun,
	year = {2010},
	keywords = {Adenocarcinoma, Aged, Aged, 80 and over, Humans, Male, Middle Aged, Neoplasm Staging, Practice Guidelines as Topic, Prognosis, Prostate-Specific Antigen, Prostatic Neoplasms, ROC Curve},
	pages = {339--343},
}

Paper  doi  bibtex   

@article{agosta_apolipoprotein_2009,
	title = {Apolipoprotein {E} epsilon4 is associated with disease-specific effects on brain atrophy in {Alzheimer}'s disease and frontotemporal dementia},
	volume = {106},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19164761},
	doi = {10.1073/pnas.0812697106},
	number = {6},
	journal = {Proc Natl Acad Sci U S A},
	author = {Agosta, F. and Vossel, K.A. and Miller, B.L. and Migliaccio, R. and Bonasera, S.J. and Filippi, M. and Boxer, A.L. and Karydas, A. and Possin, K.L. and Gorno-Tempini, M.L.},
	year = {2009},
	keywords = {\#nosource, Adult, Aged, Aged, 80 and over, Alzheimer Disease/*pathology, Apolipoprotein E4/*genetics, Atrophy, Brain Mapping, Brain/*pathology, Case-Control Studies, Dementia/*pathology, Gene Frequency, Hippocampus/pathology, Humans, Middle Aged, Parietal Lobe/pathology, Prognosis, Temporal Lobe/*pathology},
	pages = {2018--22},
}

Paper  abstract   bibtex   

@article{
 id = {8364c8e1-57a1-3484-94df-1bd37d5d7010},
 title = {Nonlinear measure of synchrony between blood oxygen saturation and heart rate from nocturnal pulse oximetry in obstructive sleep apnoea syndrome.},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Aged, 80 and over,Algorithms,Data Interpretation, Statistical,Entropy,Female,Heart Rate,Heart Rate: physiology,Humans,Male,Middle Aged,Nonlinear Dynamics,Oximetry,Oxygen,Oxygen: blood,Polysomnography,ROC Curve,Reproducibility of Results,Sleep Apnea, Obstructive,Sleep Apnea, Obstructive: blood,Sleep Apnea, Obstructive: physiopathology,Young Adult},
 created = {2012-06-13T03:54:21.000Z},
 pages = {967-82},
 volume = {30},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19696463},
 month = {9},
 accessed = {2010-08-14},
 file_attached = {true},
 profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},
 group_id = {ba0deb47-e19a-3151-83cc-b6262d5edb6e},
 last_modified = {2014-07-19T19:17:42.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Alvarez2009b},
 client_data = {"desktop_id":"5adc2c25-73db-4b77-aed2-d32a75858a27"},
 abstract = {This study focuses on analysis of the relationship between changes in blood oxygen saturation (SaO(2)) and heart rate (HR) recordings from nocturnal pulse oximetry (NPO) in patients suspected of suffering from obstructive sleep apnoea (OSA) syndrome. Two different analyses were developed: a classical frequency analysis based on the magnitude squared coherence (MSC) and a nonlinear analysis by means of a recently developed measure of synchrony, the cross-approximate entropy (cross-ApEn). A data set of 187 subjects was studied. We found significantly higher correlation and synchrony between oximetry signals from OSA positive patients compared with OSA negative subjects. We assessed the diagnostic ability to detect OSA syndrome of both the classical and nonlinear approaches by means of receiver operating characteristic (ROC) analyses with tenfold cross-validation. The nonlinear measure of synchrony significantly improved the results obtained with classical MSC: 69.2% sensitivity, 90.9% specificity and 78.1% accuracy were reached with MSC, whereas 83.7% sensitivity, 84.3% specificity and 84.0% accuracy were obtained with cross-ApEn. Our results suggest that the use of nonlinear measures of synchrony could provide essential information from oximetry signals, which cannot be obtained with classical spectral analysis.},
 bibtype = {article},
 author = {Alvarez, D and Hornero, R and Abásolo, D and del Campo, F and Zamarrón, C and López, M},
 journal = {Physiological measurement},
 number = {9}
}

Website  abstract   bibtex   

@article{
 title = {MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Aged,Aged, 80 and over,Alzheimer Disease/genetics/*pathology/psychology,Amyloid beta-Protein/cerebrospinal fluid,Apolipoproteins E/*genetics,Biological Markers/cerebrospinal fluid,Cognition Disorders/etiology,Disease Progression,Female,Genetic Predisposition to Disease,Genotype,Hippocampus/*pathology,Humans,Magnetic Resonance Imaging/methods,Male,Peptide Fragments/cerebrospinal fluid,Polymorphism, Genetic/genetics,Psychiatric Status Rating Scales,Sample Size},
 pages = {1067-1077},
 volume = {132},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19251758},
 edition = {2009/03/03},
 id = {61a4bbcd-3b8f-34b8-a3c7-c58df58db770},
 created = {2017-06-19T13:45:55.655Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:45:55.771Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Schuff, N<m:linebreak/>Woerner, N<m:linebreak/>Boreta, L<m:linebreak/>Kornfield, T<m:linebreak/>Shaw, L M<m:linebreak/>Trojanowski, J Q<m:linebreak/>Thompson, P M<m:linebreak/>Jack, C R Jr<m:linebreak/>Weiner, M W<m:linebreak/>Alzheimer's Disease Neuroimaging Initiative<m:linebreak/>U01 AG024904-01/AG/NIA NIH HHS/United States<m:linebreak/>Multicenter Study<m:linebreak/>Research Support, N.I.H., Extramural<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>England<m:linebreak/>Brain : a journal of neurology<m:linebreak/>awp007<m:linebreak/>Brain. 2009 Apr;132(Pt 4):1067-77. Epub 2009 Feb 27.</m:note>},
 abstract = {Hippocampal volume change over time, measured with MRI, has huge potential as a marker for Alzheimer's disease. The objectives of this study were: (i) to test if constant and accelerated hippocampal loss can be detected in Alzheimer's disease, mild cognitive impairment and normal ageing over short periods, e.g. 6-12 months, with MRI in the large multicentre setting of the Alzheimer's Disease Neuroimaging Initiative (ADNI); (ii) to determine the extent to which the polymorphism of the apolipoprotein E (ApoE) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, such as the beta-amyloid (Abeta(1-42)) and tau proteins (tau). The MRI multicentre study included 112 cognitive normal elderly individuals, 226 mild cognitive impairment and 96 Alzheimer's disease patients who all had at least three successive MRI scans, involving 47 different imaging centres. The mild cognitive impairment and Alzheimer's disease groups showed hippocampal volume loss over 6 months and accelerated loss over 1 year. Moreover, increased rates of hippocampal loss were associated with presence of the ApoE allele epsilon4 gene in Alzheimer's disease and lower CSF Abeta(1-42) in mild cognitive impairment, irrespective of ApoE genotype, whereas relations with tau were only trends. The power to measure hippocampal change was improved by exploiting correlations statistically between successive MRI observations. The demonstration of considerable hippocampal loss in mild cognitive impairment and Alzheimer's disease patients over only 6 months and accelerated loss over 12 months illustrates the power of MRI to track morphological brain changes over time in a large multisite setting. Furthermore, the relations between faster hippocampal loss in the presence of ApoE allele epsilon4 and decreased CSF Abeta(1-42) supports the concept that increased hippocampal loss is an indicator of Alzheimer's disease pathology and a potential marker for the efficacy of therapeutic interventions in Alzheimer's disease.},
 bibtype = {article},
 author = {Schuff, N and Woerner, N and Boreta, L and Kornfield, T and Shaw, L M and Trojanowski, J Q and Thompson, P M and Jack  Jr., C R and Weiner, M W},
 journal = {Brain},
 number = {Pt 4}
}

@article{hawkins_no_2009-1,
	title = {No study left behind: a network meta-analysis in non–small-cell lung cancer demonstrating the importance of considering all relevant data},
	volume = {12},
	number = {6},
	journal = {Value in health},
	author = {Hawkins, Neil and Scott, David A and Woods, Beth S and Thatcher, Nicholas},
	year = {2009},
	keywords = {80 and over, Adult, Aged, Antineoplastic Agents, Bias, Carcinoma, Data Interpretation, Docetaxel, Erlotinib Hydrochloride, Female, Humans, Lung Neoplasms, Male, Middle Aged, Non-Small-Cell Lung, oncology, Proportional Hazards Models, Protein Kinase Inhibitors, Quinazolines, Randomized Controlled Trials as Topic, Research Design, Statistical, Taxoids, Young Adult},
	pages = {996--1003},
	file = {Hawkins et al. - 2009 - No Study Left Behind A Network Meta-Analysis in N.pdf:/Users/neil.hawkins/Zotero/storage/X42T8EEQ/Hawkins et al. - 2009 - No Study Left Behind A Network Meta-Analysis in N.pdf:application/pdf},
}

@article{boussekey_pilot_2008,
	title = {A pilot randomized study comparing high and low volume hemofiltration on vasopressor use in septic shock.},
	volume = {34},
	issn = {0342-4642 0342-4642},
	doi = {10.1007/s00134-008-1127-3},
	abstract = {OBJECTIVE: High volume hemofiltration (HVHF) has shown potential benefits in septic animals and a few reports suggested a hemodynamic improvement in humans. However, randomized studies are still lacking. Our goal was to evaluate the hemodynamic effects of HVHF in septic shock patients with acute renal failure (ARF). DESIGN AND SETTING: Prospective randomized study in an intensive care unit (ICU). PATIENTS: Twenty patients with septic shock and ARF. INTERVENTIONS: Patients were randomized to either high volume hemofiltration [HVHF 65 ml/(kg h)] or low volume hemofiltration [LVHF 35 ml/(kg h). Vasopressor dose was adjusted to reach a mean arterial pressure (MAP) {\textgreater} 65 mmHg. MEASUREMENTS AND RESULTS: We performed six hourly measurements of MAP, norepinephrine dose, PaO(2)/FiO(2) and  lactate, and four daily urine output and logistic organ dysfunction (LOD) score.  Baseline characteristics of the two groups were comparable on randomization. Mean norepinephrine dose decreased more rapidly after 24 h of HVHF treatment compared  to LVHF treatment (P = 0.004) whereas lactate and PaO(2)/FiO(2) did not differ between the two treatment groups. During the 4-day follow-up, urine output was slightly increased in the HVHF group (P = 0.059) but the LOD score evolution was  not different. Duration of mechanical ventilation, renal replacement therapy and  ICU length of stay were also comparable. Survival on day 28 was not affected. CONCLUSION: HVHF decreased vasopressor requirement and tended to increase urine output in septic shock patients with renal failure. However, a larger trial is required to confirm our results and perhaps to show a benefit in survival.},
	language = {eng},
	number = {9},
	journal = {Intensive care medicine},
	author = {Boussekey, Nicolas and Chiche, Arnaud and Faure, Karine and Devos, Patrick and Guery, Benoit and d'Escrivan, Thibaud and Georges, Hugues and Leroy, Olivier},
	month = sep,
	year = {2008},
	pmid = {18542921},
	keywords = {Humans, Adult, Female, Aged, Intensive Care Units, Male, Middle Aged, Aged, 80 and over, *Hospital Mortality, Acute Kidney Injury/*complications/*therapy, APACHE, Blood Pressure/drug effects, Hemofiltration/*methods, Norepinephrine/administration \& dosage/*therapeutic use, Respiration, Artificial, Shock, Septic/classification/*complications/*therapy, Vasoconstrictor Agents/administration \& dosage/*therapeutic use},
	pages = {1646--1653}
}

Paper  Website  abstract   bibtex   

@article{
 title = {1.4T study of proton magnetic relaxation rates, iron concentrations, and plaque burden in Alzheimer's disease and control postmortem brain tissue},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {*Brain Chemistry,*Plaque,*Senile Plaques,80 and over,Aged,Alzheimer Disease/*metabolism/*pathology,Amyloid,Female,Humans,Iron/*analysis,Magnetic Resonance Spectroscopy/*methods,Male},
 pages = {41-52},
 volume = {60},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18523986},
 id = {2e510ac5-7c59-3b6b-8c1b-12dc1cf30bca},
 created = {2016-09-21T08:35:05.000Z},
 file_attached = {true},
 profile_id = {5d250c3e-485a-3099-8087-b35242bd2203},
 group_id = {a9625e9e-5a77-317b-ab12-c1d6dcc9ef27},
 last_modified = {2016-09-25T08:31:21.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {House2008},
 abstract = {We measured proton magnetic longitudinal (R(1)) and transverse (R(2)) relaxation rates at 1.4T, iron concentrations, water contents, and amyloid plaque densities in postmortem brain tissue samples from three Alzheimer's disease (AD), two possible AD, and five control subjects. Iron concentrations and R(1) were significantly higher in the temporal cortex region of our AD group compared to the controls. Frequency analyses showed that the observed trends of higher iron, R(1), and R(2) in AD gray matter regions were statistically significant. Simple regression models indicated that for AD and control gray matter the iron concentrations and water contents have significant linear correlations with R(1) and R(2). Multiple regression models based on iron concentrations and water contents were highly significant for all groups and tissue types and suggested that the effects of iron become more important in determining R(1) and R(2) in the AD samples. At 1.4T R(1) and R(2) are strongly affected by water content and to a lesser extent by variations in iron concentrations. The AD plaque density did not correlate with iron concentrations, water contents, R(1), or R(2), suggesting that increases in AD brain iron are not strongly related to the accumulation of amyloid plaques.},
 bibtype = {article},
 author = {House, M J and St Pierre, T G and McLean, C},
 journal = {Magn Reson Med},
 number = {1}
}

@article{edwards_efficacy_2007,
	title = {Efficacy and safety of galantamine in patients with dementia with {Lewy} bodies: a 24-week open-label study},
	volume = {23},
	issn = {1420-8008},
	shorttitle = {Efficacy and safety of galantamine in patients with dementia with {Lewy} bodies},
	doi = {10.1159/000101512},
	abstract = {BACKGROUND: Dementia with Lewy bodies (DLB) is a common dementia of the elderly. A significant cholinergic deficit has been demonstrated that may be responsive to treatment by cholinesterase inhibitors (ChEIs).
METHODS: A 24-week, open-label study was designed to assess the efficacy and safety of a ChEI, galantamine, in 50 patients with DLB.
RESULTS: This study showed beneficial effects with galantamine in 2 of the 3 primary efficacy parameters. The scores on the Neuropsychiatric Inventory (NPI-12) improved by 8.24 points from baseline (p = 0.01) especially in visual hallucinations and nighttime behaviors (p = 0.004). The scores on the Clinician's Global Impression of Change improved by 0.5 points from baseline (p = 0.01). The third primary efficacy parameter, the Cognitive Drug Research Computerized Cognitive Assessment System, was unchanged from baseline. Adverse events were generally mild and transient.
CONCLUSION: Galantamine appears to be an effective and safe therapy for patients with DLB.},
	language = {eng},
	number = {6},
	journal = {Dementia and Geriatric Cognitive Disorders},
	author = {Edwards, Keith and Royall, Donald and Hershey, Linda and Lichter, David and Hake, Ann and Farlow, Martin and Pasquier, Florence and Johnson, Stewart},
	year = {2007},
	pmid = {17409748},
	keywords = {Aged, Humans, Dementia, Female, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Aged, 80 and over, Treatment Outcome, Mental Status Schedule, Behavioral Symptoms, Cholinesterase Inhibitors, Galantamine, Lewy Body Disease, Dose-Response Relationship, Drug, Hallucinations, Parkinsonian Disorders},
	pages = {401--405}
}

@article{srinivasan_risk_2007,
	title = {Risk of colorectal cancer in women with a prior diagnosis of gynecologic malignancy},
	volume = {41},
	issn = {0192-0790},
	doi = {10.1097/01.mcg.0000225587.85953.06},
	abstract = {GOALS AND BACKGROUND: Earlier studies regarding the risk of colorectal cancer (CRC) in women with a prior diagnosis of gynecologic malignancies have revealed conflicting results. We sought to further clarify this association.
METHODS: A retrospective cohort study was performed using the General Practice Research Database of the United Kingdom. Patients with a prior diagnosis of ovarian, uterine, or cervical cancers were compared with control patients without a prior gynecologic malignancy. The primary outcome was a diagnosis of CRC. Poisson regression analysis was used to assess the effects of potential confounders.
RESULTS: The study included 1995 ovarian, 1348 uterine, and 1101 cervical cancer patients and 7980, 5392, and 4404 matched control patients, respectively. The adjusted incidence rate ratio (IRR) of CRC among ovarian cancer patients was 2.90 [95\% confidence intervals (CI) 1.45-5.82]. Five of 10 cases of CRC in ovarian cancer patients were diagnosed within 6 months of the cancer diagnosis with an adjusted IRR of 8.0 (95\% CI 1.9-33.6). Excluding the initial 6 months of follow-up after the diagnosis of ovarian cancer, the adjusted IRR was 1.6 (95\% CI 0.76-5.03). The adjusted IRR of CRC in patients with a prior diagnosis of uterine and cervical cancer was 0.79 (95\% CI 0.24-2.61) and 1.50 (95\% CI 0.43-5.21), respectively.
CONCLUSIONS: Women with a prior diagnosis of ovarian cancer are at an increased risk of CRC. The risk of CRC was not increased among patients with a prior history of uterine and cervical cancer.},
	language = {eng},
	number = {3},
	journal = {Journal of Clinical Gastroenterology},
	author = {Srinivasan, Radhika and Yang, Yu-Xiao and Rubin, Stephen C. and Morgan, Mark A. and Lewis, James D.},
	month = mar,
	year = {2007},
	pmid = {17426469},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Child, Cohort Studies, Colorectal Neoplasms, Female, Genital Neoplasms, Female, Humans, Middle Aged, Ovarian Neoplasms, Retrospective Studies, Risk, Uterine Cervical Neoplasms, Uterine Neoplasms},
	pages = {291--296}
}

@article{fox_prevalence_2006,
	title = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database: {A} series of retrospective analyses of data from 1998 through 2002},
	volume = {28},
	issn = {0149-2918},
	shorttitle = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database},
	doi = {10.1016/j.clinthera.2006.03.005},
	abstract = {BACKGROUND: Since the mid-1990s, the development of new oral antidiabetic agents (OAs) and treatment guidelines have created an opportunity to improve glycemic control in patients with type 2 diabetes.
OBJECTIVES: This study aimed to assess the prevalence of good and inadequate glycemic control across a 5-year period among patients with diabetes in the United Kingdom. It also investigated the factors associated with achieving glycemic targets.
METHODS: This was a retrospective, cross-sectional analysis of data from the General Practice Research Database. Three limits were used to assess glycosylated hemoglobin (HbA1c): 6.5\%, 7.0\%, or 7.5\%. Values above the cutoffs indicated inadequate control of HbA1c; those at or below the cutoffs indicated good control. The study evaluated clinical and pharmacy data from the years 1998 to 2002 for patients with type 2 diabetes, {\textgreater} or =2 years of follow-up, and {\textgreater} or =2 HbA1c measurements during the first year. Five independent cross-sectional analyses were conducted, grouping data by year. Statistical significance was determined by Student t and chi2 tests.
RESULTS: Data were analyzed for 10,663 patients aged 17 to 98 years. The number of total eligible type 2 diabetes patients increased over the course of the study period: 5674 patients in 1998, 6553 in 1999, 7314 in 2000, 7323 in 2001, and 6192 in 2002. Overall, the study population had a mean (SD) age of 66 (11.0) years, was 53\% male (3033/5674), and had a body mass index of 29 kg/m(2). Seventy-six percent of patients had HbA1c {\textgreater}7.0\% and 37\% were taking {\textgreater} or =2 oral agents. In 1998 and 2002, 79\% (4482/5674) and 76\% (4732/6192) of patients, respectively, had inadequate glycemic control, defined as HbA1c {\textgreater}7.0\%. When defined as HbA1c {\textgreater}7.5\%, 69\% (3923/5674) and 62\% (3814/6192) of patients, respectively, had inadequate control. Finally, when defined as HbA1c {\textgreater}6.5\%, 88\% (5011/5674) of patients in both 1998 and 2002 had inadequate control. Compared with patients with good disease control (HbA1c {\textless} or =7.0\%), patients with inadequate control were approximately 2 years younger (P {\textless} 0.001) and had been prescribed more OAs: 41\% received {\textgreater} or =2 OAs in 1998 and 52\% in 2002, compared with 23\% and 34\% (both, P = 0.001), respectively, of patients with good glycemic control (P {\textless} 0.02). Sex, number of diabetes complications, and number of comorbidities did not differ between groups (P = NS).
CONCLUSIONS: Despite the introduction of new OAs and treatment guidelines, the prevalence of inadequate glycemic control remains high ({\textgreater}60\%) in patients with type 2 diabetes in the United Kingdom. Regardless of the HbA1c cutoff, patients with inadequate control were younger and received prescriptions for more OAs than patients with good control.},
	language = {eng},
	number = {3},
	journal = {Clinical Therapeutics},
	author = {Fox, Kathleen M. and Gerber Pharmd, Robert A. and Bolinder, Bjorn and Chen, Jack and Kumar, Sanjaya},
	month = mar,
	year = {2006},
	pmid = {16750453},
	keywords = {Administration, Oral, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Family Practice, Female, Great Britain, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prevalence, Retrospective Studies, databases as topic},
	pages = {388--395}
}

@article{shepherd_comparison_2006,
	title = {Comparison of {BMD} precision for {Prodigy} and {Delphi} spine and femur scans},
	volume = {17},
	issn = {0937-941X},
	doi = {10.1007/s00198-006-0127-9},
	abstract = {INTRODUCTION: Precision error in bone mineral density (BMD) measurement can be affected by patient positioning, variations in scan analysis, automation of software, and both short- and long-term fluctuations of the densitometry equipment. Minimization and characterization of these errors is essential for reliable assessment of BMD change over time.
METHODS: We compared the short-term precision error of two dual-energy X-ray absorptiometry (DXA) devices: the Lunar Prodigy (GE Healthcare) and the Delphi (Hologic). Both are fan-beam DXA devices predominantly used to measure BMD of the spine and proximal femur. In this study, 87 women (mean age 61.6+/-8.9 years) were measured in duplicate, with repositioning, on both systems, at one of three clinical centers. The technologists were International Society for Clinical Densitometry (ISCD) certified and followed manufacturer-recommended procedures. All scans were acquired using 30-s scan modes. Precision error was calculated as the root-mean-square standard deviation (RMS-SD) and coefficient of variation (RMS-\%CV) for the repeated measurements. Right and left femora were evaluated individually and as a combined dual femur precision. Precision error of Prodigy and Delphi measurements at each measurement region was compared using an F test to determine significance of any observed differences.
RESULTS: While precision errors for both systems were low, Prodigy precision errors were significantly lower than Delphi at L1-L4 spine (1.0\% vs 1.2\%), total femur (0.9\% vs 1.3\%), femoral neck (1.5\% vs 1.9\%), and dual total femur (0.6\% vs 0.9\%). Dual femur modes decreased precision errors by approximately 25\% compared with single femur results.
CONCLUSIONS: This study suggests that short-term BMD precision errors are skeletal-site and manufacturer specific. In clinical practice, precision should be considered when determining: (a) the minimum time interval between baseline and follow-up scans and (b) whether a statistically significant change in the patient's BMD has occurred.},
	language = {eng},
	number = {9},
	journal = {Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA},
	author = {Shepherd, J. A. and Fan, B. and Lu, Y. and Lewiecki, E. M. and Miller, P. and Genant, H. K.},
	year = {2006},
	pmid = {16823544},
	keywords = {Absorptiometry, Photon, Aged, Aged, 80 and over, Bone Density, Female, Femur, Femur Neck, Hip Joint, Humans, Lumbar Vertebrae, Middle Aged, Osteoporosis, Postmenopausal, Postmenopause, Reproducibility of Results},
	pages = {1303--1308}
}

@article{latinovic_incidence_2006,
	title = {Incidence of common compressive neuropathies in primary care},
	volume = {77},
	issn = {0022-3050},
	doi = {10.1136/jnnp.2005.066696},
	abstract = {Apart from carpal tunnel syndrome, there are no population based studies of the epidemiology of compressive neuropathies. To provide this information, new presentations of compressive neuropathies among patients registered with 253 general practices in the UK General Practice Research Database with 1.83 million patient years at risk in 2000 were analysed. The study revealed that in 2000 the annual age standardised rates per 100 000 of new presentations in primary care were: carpal tunnel syndrome, men 87.8/women 192.8; Morton's metatarsalgia, men 50.2/women 87.5; ulnar neuropathy, men 25.2/women 18.9; meralgia paraesthetica, men 10.7/women 13.2; and radial neuropathy, men 2.97/women 1.42. New presentations were most frequent at ages 55-64 years except for carpal tunnel syndrome, which was most frequent in women aged 45-54 years, and radial nerve palsy, which was most frequent in men aged 75-84 years. In 2000, operative treatment was undertaken for 31\% of new presentations of carpal tunnel syndrome, 3\% of Morton's metatarsalgia, and 30\% of ulnar neuropathy.},
	language = {eng},
	number = {2},
	journal = {Journal of Neurology, Neurosurgery, and Psychiatry},
	author = {Latinovic, R. and Gulliford, M. C. and Hughes, R. a. C.},
	month = feb,
	year = {2006},
	pmid = {16421136},
	pmcid = {PMC2077603},
	keywords = {Adult, Age Factors, Aged, Aged, 80 and over, Carpal Tunnel Syndrome, Cross-Sectional Studies, Female, Great Britain, Humans, Male, Metatarsalgia, Middle Aged, Nerve Compression Syndromes, Primary Health Care, Radial Neuropathy, Sex Factors, Ulnar Neuropathies, incidence},
	pages = {263--265}
}

@article{jones_physical_2006,
	title = {Physical and psychological co-morbidity in irritable bowel syndrome: a matched cohort study using the {General} {Practice} {Research} {Database}},
	volume = {24},
	issn = {0269-2813},
	shorttitle = {Physical and psychological co-morbidity in irritable bowel syndrome},
	doi = {10.1111/j.1365-2036.2006.03044.x},
	abstract = {BACKGROUND: Irritable bowel syndrome is a common problem known to have a complex relationship with psychological disorders and other physical symptoms. Little information, however, is available concerning physical and psychological comorbidity in irritable bowel syndrome patients studied over an extended period.
AIM: To evaluate physical and psychological morbidity 2 years before and during 6 years after the time of diagnosis in incident cases of irritable bowel syndrome and control subjects.
METHODS: A matched cohort study was implemented in 123 general practices using the General Practice Research Database. Irritable bowel syndrome cases (n = 1827) and controls (n = 3654) were compared for 2 years before and 6 years after diagnosis.
RESULTS: The age-standardized incidence of irritable bowel syndrome in patients over 15 years of age was 1.9 per 1,000 in men and 5.8 per 1,000 in women. From 2 years before the date of diagnosis, more irritable bowel syndrome cases (13\%) than controls (5\%) consulted with depression or were prescribed antidepressant drugs. Consultation and prescription rates for anxiety were also higher before diagnosis, and both anxiety and depression remained prevalent up to 6 years after diagnosis. Asthma, symptoms of urinary tract infection, gall-bladder surgery, hysterectomy and diverticular disease were recorded more frequently in irritable bowel syndrome patients, who were also more likely than controls to be referred to hospital.
CONCLUSIONS: People who are diagnosed with irritable bowel syndrome experience more anxiety and depression and a range of physical problems, compared with controls; they are more likely to be referred to hospital.},
	language = {eng},
	number = {5},
	journal = {Alimentary Pharmacology \& Therapeutics},
	author = {Jones, R. and Latinovic, R. and Charlton, J. and Gulliford, M.},
	month = sep,
	year = {2006},
	pmid = {16918893},
	keywords = {Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Asthma, Cohort Studies, Comorbidity, Databases, Factual, Diverticulum, Family Practice, Female, Gallbladder Diseases, Great Britain, Hospitalization, Humans, Hysterectomy, Irritable Bowel Syndrome, Male, Middle Aged, Prevalence, Sex Distribution, Urinary Tract Infections, anxiety, depression, incidence},
	pages = {879--886}
}

@article{frank_effects_2005,
	title = {Effects of compulsory treatment orders on time to hospital readmission},
	volume = {56},
	issn = {1075-2730},
	doi = {10.1176/appi.ps.56.7.867},
	abstract = {To evaluate the effect of compulsory community treatment orders on subsequent time out of the hospital, the authors studied the admission dates of psychotic patients who had repeated hospitalizations in Quebec, Canada, and divided each admission according to its time in relation to the index admission, during which the judicial order was obtained. The data were stratified by type of admission (early, preindex, index, or postindex), and the hypothesis tested was that the median time to readmission would be greatest for the index admission. The hypothesis was confirmed, supporting previous findings that judicial orders that mandate severely ill psychotic patients to undergo compulsory community treatment are associated with decreased time spent in the hospital and thus increased personal freedom.},
	language = {eng},
	number = {7},
	journal = {Psychiatric Services (Washington, D.C.)},
	author = {Frank, Daniel and Perry, J. Christopher and Kean, Dana and Sigman, Maxine and Geagea, Khalil},
	month = jul,
	year = {2005},
	pmid = {16020822},
	keywords = {Adult, Aged, Aged, 80 and over, Commitment of Mentally Ill, Community Mental Health Services, Female, Follow-Up Studies, Hospitalization, Humans, Male, Mental Disorders, Middle Aged, Patient Admission, Quebec, Time Factors, Treatment Outcome},
	pages = {867--869},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Biological evidence for inheritance of exceptional longevity},
 type = {article},
 year = {2005},
 identifiers = {[object Object]},
 keywords = {Age Factors,Aged,Aged, 80 and over,Aging/*ethnology/*genetics,Alleles,Carrier Proteins/genetics,Case-Control Studies,Genotype,Glycoproteins/genetics,Homozygote,Humans,Lipids/metabolism,Lipoproteins, HDL/genetics/metabolism,Lipoproteins, LDL/genetics/metabolism,Longevity/*genetics,Phenotype,Polymorphism, Genetic,Valine/genetics},
 pages = {341-345},
 volume = {126},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15621216},
 id = {ac53ce7e-fc6c-35da-8438-be74b645fce9},
 created = {2017-06-19T13:45:30.857Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:45:31.024Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0047-6374<m:linebreak/>Journal Article</m:note>},
 abstract = {Subjects with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility. In a case control study, we aim to determine phenotype and genotype of exceptional longevity in a genetically homogenous population (Ashkenazi Jews), and their offspring, while an age-matched control group of Ashkenazi Jews was used as control groups. We demonstrated that exceptional longevity and healthy aging in humans is an inherited phenotype across three generations. Moreover, we demonstrated that subjects with exceptional longevity and their offspring have significantly larger high-density lipoprotein (HDL) levels and particle sizes and low-density lipoprotein (LDL) levels that reflect on their health and cognitive function performance. This phenotype have led us to study candidate genes involved in lipoprotein metabolism, and to the implication of homozygosity for the 405 valine (V) allele of cholesteryl ester transfer protein (CETP). A markedly higher frequency of a functional CETP variant that led to increased particle sizes of HDL and LDL and thus a better health performance is the first example of a phenotype and an associated genotype in humans with exceptional longevity. Hopefully, this line of research will lead us to establish which genotype is necessary (although not necessary sufficient) for a prolonged disease-free aging.},
 bibtype = {article},
 author = {Atzmon, G and Rincon, M and Rabizadeh, P and Barzilai, N},
 journal = {Mech Ageing Dev},
 number = {2}
}

Paper  doi  abstract   bibtex   

@article{liu_truncation_2005,
	title = {Truncation and activation of calcineurin {A} by calpain {I} in {Alzheimer} disease brain},
	volume = {280},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16150694},
	doi = {10/fxdq5g},
	abstract = {A disturbance of calcium homeostasis is believed to play an important role in the neurodegeneration of the brains of Alzheimer disease (AD) patients, but the molecular pathways by which it contributes to the disease are not well understood. Here we studied the activation of two major Ca(2+)-regulated brain proteins, calpain and calcineurin, in AD brain. We found that calpain I is activated, which in turn cleaves and activates calcineurin in AD brain. Mass spectrometric analysis indicated that the cleavage of calcineurin by calpain I is at lysine 501, a position C-terminal to the autoinhibitory domain, which produces a 57-kDa truncated form. The 57-kDa calcineurin maintains its Ca(2+)/calmodulin dependence of the phosphatase activity, but the phosphatase activity is remarkably activated upon truncation. The cleavage and activation of calcineurin correlate to the number of neurofibrillary tangles in human brains. These findings suggest that the overactivation of calpain I and calcineurin may mediate the role of calcium homeostatic disturbance in the neurodegeneration of AD.},
	number = {45},
	journal = {J Biol Chem},
	author = {Liu, F. and Grundke-Iqbal, I. and Iqbal, K. and Oda, Y. and Tomizawa, K. and Gong, C.X.},
	year = {2005},
	keywords = {Aged, Aged, 80 and over, Alzheimer Disease/*metabolism, Amino Acid Sequence, Brain/*enzymology, Calcineurin/chemistry/*metabolism, Calcium Signaling, Calpain/*metabolism, Enzyme Activation, Female, Humans, Male, Molecular Sequence Data},
	pages = {37755--62},
}

Paper  doi  abstract   bibtex   

@article{hillis_anatomy_2005,
	title = {Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke},
	volume = {25},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15788773},
	doi = {10/dfqkdz},
	abstract = {The site of lesion responsible for left hemispatial neglect after stroke has been intensely debated recently. Some studies provide evidence that right angular lesions are most likely to cause left neglect, whereas others indicate that right superior temporal lesions are most likely to cause neglect. We examine two potential accounts of the conflicting results: (1) neglect could result from cortical dysfunction beyond the structural lesion in some studies; and (2) different forms of neglect with separate neural correlates have been included in different proportions in separate studies. To evaluate these proposals, we studied 50 patients with acute right subcortical infarcts using tests of hemispatial neglect and magnetic resonance diffusion-weighted and perfusion-weighted imaging performed within 48 h of onset of symptoms. Left "allocentric" neglect (errors on the left sides of individual stimuli, regardless of location with respect to the viewer) was most strongly associated with hypoperfusion of right superior temporal gyrus (Fisher's exact test; p {\textless} 0.0001), whereas left "egocentric" neglect (errors on the left of the viewer) was most strongly associated with hypoperfusion of the right angular gyrus (p {\textless} 0.0001). Patients without cortical hypoperfusion showed no hemispatial neglect. Because the patients did not have cortical infarcts, our data show that neglect can be caused by hypoperfused dysfunctional tissue not detectable by structural magnetic resonance imaging. Moreover, different forms of neglect were associated with different sites of cortical hypoperfusion. Results help explain conflicting results in the literature and contribute to the understanding of spatial attention and representation in the human brain.},
	number = {12},
	journal = {Journal of Neuroscience},
	author = {Hillis, A.E. and Newhart, M. and Heidler, J. and Barker, P.B. and Herskovits, E.H. and Degaonkar, M.},
	year = {2005},
	keywords = {\#nosource, Adult, Aged, Aged, 80 and over, Attention/*physiology, Brain Mapping, Brain/pathology, Cerebrovascular Accident/*complications/pathology, Diffusion Magnetic Resonance Imaging/methods, Female, Functional Laterality/physiology, Humans, Image Processing, Computer-Assisted/methods, Male, Middle Aged, Neuropsychological Tests, Perceptual Disorders/classification/*etiology/*pathology, Space Perception/*physiology},
	pages = {3161--3167},
}

@article{fischer_discontinuation_2004,
	title = {Discontinuation of nonsteroidal anti-inflammatory drug therapy and risk of acute myocardial infarction},
	volume = {164},
	issn = {0003-9926},
	doi = {10.1001/archinte.164.22.2472},
	abstract = {BACKGROUND: Systemic inflammation has been shown to be associated with an increased risk of acute myocardial infarction (AMI). However, the effect of the use of nonsteroidal anti-inflammatory drugs (NSAIDs) on the risk of AMI has not yet been well defined. We therefore studied the risk of AMI during NSAID exposure and after the cessation of NSAID therapy.
METHODS: We conducted a large case-control analysis on the British General Practice Research Database. The study included 8688 cases with a first-time AMI between 1995 and 2001 and 33 923 controls, matched to cases on age, sex, calendar time, and general practice attended.
RESULTS: After adjusting for hypertension, hyperlipidemia, diabetes mellitus, ischemic heart disease, rheumatoid arthritis, systemic lupus erythematosus, acute chest infection, body mass index, smoking, and aspirin use, the risk of AMI was 1.52 (95\% confidence interval [CI], 1.33-1.74) for subjects who stopped taking NSAIDs 1 to 29 days prior to the index date, compared with nonusers. The risk was highest in subjects with rheumatoid arthritis or systemic lupus erythematosus (adjusted OR, 3.68 [95\% CI, 2.36-5.74]) and for subjects who discontinued therapy with NSAIDs after previous long-term use (adjusted OR, 2.60 [95\% CI, 1.84-3.68]). Current and past NSAID use (discontinued therapy {\textgreater}/=60 days prior to the index date) were not associated with an increased risk of AMI (adjusted OR, 1.07 [95\% CI, 0.96-1.19] and 1.05 [95\% CI, 0.99-1.12], respectively).
CONCLUSION: Our findings suggest that the risk of AMI is increased during several weeks after the cessation of NSAID therapy.},
	language = {eng},
	number = {22},
	journal = {Archives of Internal Medicine},
	author = {Fischer, Lorenz M. and Schlienger, Raymond G. and Matter, Christian M. and Jick, Hershel and Meier, Christoph R.},
	month = dec,
	year = {2004},
	pmid = {15596638},
	keywords = {Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Rheumatoid, Female, Humans, Lupus Erythematosus, Systemic, Male, Middle Aged, Myocardial Infarction, Substance Withdrawal Syndrome},
	pages = {2472--2476}
}

@article{boyle_5-alpha_2004,
	title = {5-{Alpha} reductase inhibition provides superior benefits to alpha blockade by preventing {AUR} and {BPH}-related surgery},
	volume = {45},
	issn = {0302-2838},
	doi = {10.1016/j.eururo.2003.09.012},
	abstract = {OBJECTIVES: This analysis examines the relative effectiveness of current medical therapies for BPH in preventing AUR, AUR-related catheterisation and surgery in real-life clinical practice.
METHODS: This is a retrospective analysis of observational data from the General Practice Research Database (UK) (GPRD). The cohort contains 4500 patients experiencing BPH or lower urinary tract symptoms strongly suggestive of BPH, aged over 50 years, who were prescribed a 5ARI (finasteride) or an alpha-blocker (alfuzosin, doxazosin, indoramin, prazosin, tamsulosin, terazosin) as their first BPH treatment between 1996 and 1999 inclusive. Cox regression and competing risks analyses, adjusted for age and year of first treatment, followed patients from the start of their first BPH treatment to AUR, catheterisation or surgery, or censoring.
RESULTS: Patients prescribed an alpha-blocker were significantly more likely to experience AUR (hazard ratio 2.32, 95\%CI 1.37, 3.94) or surgery (hazard ratio 1.78, 95\%CI 1.30, 2.44) than patients prescribed a 5ARI. These differences were sustained with sensitivity analyses.
CONCLUSION: Real-life clinical practice shows that significantly fewer BPH patients prescribed a 5ARI experienced serious complications associated with the progression of BPH compared with those prescribed an alpha-blocker.},
	language = {eng},
	number = {5},
	journal = {European Urology},
	author = {Boyle, P. and Roehrborn, C. and Harkaway, R. and Logie, J. and de la Rosette, J. and Emberton, M.},
	month = may,
	year = {2004},
	pmid = {15082205},
	keywords = {5-alpha Reductase Inhibitors, Acute Disease, Adrenergic alpha-Antagonists, Aged, Aged, 80 and over, Enzyme Inhibitors, Finasteride, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Prostatic Hyperplasia, Regression Analysis, Retrospective Studies, Urinary Retention},
	pages = {620--626; discussion 626--627}
}

@article{morant_application_2004,
	title = {Application of a propensity score to adjust for channelling bias with {NSAIDs}},
	volume = {13},
	issn = {1053-8569},
	doi = {10.1002/pds.946},
	abstract = {PURPOSE: To compare the relative risks of upper GI haemorrhage (UGIH) in users of Newer versus Older, non-specific NSAIDs when adjusted for channelling bias by regression on individual covariates, a propensity score and both.
METHODS: Cohort study of patients prescribed NSAIDs between June 1987 and January 2000. Exposure to Newer and Older non-specific NSAIDs was identified, and risk factors evaluated for each patient. Results of multiple covariate analyses and the propensity scoring technique to assess potential channelling bias in comparisons between Newer and Older non-specific NSAIDs were compared.
RESULTS: This study included 7.1 thousand patient years (tpy) exposure to meloxicam, 1.6 tpy exposure to coxibs, and 628 tpy exposure to Older non-specific NSAIDs. Patients receiving Newer NSAIDs were older, more likely to have a history of GI symptoms, and at higher risk for GI complications. Adjusting for these risk factors reduced the relative risks of UGIH on meloxicam and coxibs versus Older non-specific NSAIDs to 0.84 (95\%CI 0.60, 1.17) and 0.36 (0.14, 0.97) respectively.
CONCLUSIONS: Channelling towards high GI risk patients occurred in the prescribing of Newer NSAIDs. Propensity scores highlighted the markedly different risk profiles of users of Newer and Older non-specific NSAID. Correcting for channelling bias, coxib exposure, but not meloxicam exposure, was associated with less UGIH than Older non-specific NSAID exposure. In the present study, corrections made by regression on a propensity score and on individual covariates were similar.},
	language = {eng},
	number = {6},
	journal = {Pharmacoepidemiology and Drug Safety},
	author = {Morant, S. V. and Pettitt, D. and MacDonald, T. M. and Burke, T. A. and Goldstein, J. L.},
	month = jun,
	year = {2004},
	pmid = {15170763},
	keywords = {Adult, Age Factors, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Cohort Studies, Cyclooxygenase Inhibitors, Databases, Factual, Drug Utilization Review, Family Practice, Female, Gastrointestinal Hemorrhage, Great Britain, Humans, Male, Middle Aged, Osteoarthritis, Regression Analysis, Risk Factors, Sex Factors, Thiazines, Thiazoles, pharmacoepidemiology},
	pages = {345--353}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Clinical phenotype of families with longevity},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {*Family Health,Aged,Aged, 80 and over,Cardiovascular Diseases/*epidemiology/genetics,Case-Control Studies,Chronic Disease/*epidemiology,European Continental Ancestry Group/statistics & n,Female,Humans,Israel/epidemiology,Jews/statistics & numerical data,Longevity/*genetics,Male,Matched-Pair Analysis,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.,Risk,Sex Factors,Statistics, Nonparametric,United States/epidemiology},
 pages = {274-277},
 volume = {52},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14728640},
 id = {269afc28-8f71-3cb1-91c4-4f7293ce8166},
 created = {2017-06-19T13:45:32.818Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:45:32.918Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0002-8614<m:linebreak/>Journal Article</m:note>},
 abstract = {OBJECTIVES: To determine whether offspring of centenarians acquired protection from age-related diseases. DESIGN: Case-control study. SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey. MEASUREMENTS: Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass. RESULTS: Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) "risk" for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups. CONCLUSION: Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment.},
 bibtype = {article},
 author = {Atzmon, G and Schechter, C and Greiner, W and Davidson, D and Rennert, G and Barzilai, N},
 journal = {J Am Geriatr Soc},
 number = {2}
}

@article{peyriere_adverse_2003,
	title = {Adverse drug events associated with hospital admission},
	volume = {37},
	issn = {1060-0280},
	abstract = {OBJECTIVE: To increase the knowledge base on the frequency, causality, and avoidability of adverse drug events (ADEs) as a cause for admission in internal medicine or when occurring during hospitalization.
METHODS: A prospective study was performed for 6 periods of 8 days each. Epidemiologic data (e.g., age, gender, medical history), drug utilization, and adverse drug reactions on patients hospitalized during these periods were collected by a pharmacy student.
RESULTS: A total of 156 patients (70 men and 86 women) were included in the study. The patients' mean age +/- SD was 66.5 +/- 18.1 years and mean length of stay was 13.2 +/- 9 days. Renal and hepatic insufficiency and previous history of drug intolerance were observed in 17.9\%, 10.2\%, and 2\% of the hospitalized patients, respectively. Thirty-eight ADEs occurred in 32 patients; in 15 cases, ADEs were identified as the reason for admission, 10 cases occurred during hospitalization, and 13 cases were present at admission, but were not the cause of admission. The most frequent ADEs involved the neurologic (23.6\%), renal (15.7\%), and hematologic (13.1\%) systems. Among these 38 ADEs, 22 were considered avoidable (57.9\%); 20 of these were associated with therapeutic errors (inappropriate administration, drug-drug interactions, dosage error, drug not stopped despite the onset of ADEs). Patients with ADEs stayed longer in the hospital and took more drugs both before and during their hospital stay (p {\textless} 0.05).
CONCLUSIONS: Most of the ADEs observed in this study were avoidable. The risk/benefit ratio of administered drugs could be improved with better knowledge of the patients' medical history and the risk factors of ADEs.},
	language = {eng},
	number = {1},
	journal = {The Annals of Pharmacotherapy},
	author = {Peyriere, Hélène and Cassan, Stéphanie and Floutard, Edith and Riviere, Sophie and Blayac, Jean-Pierre and Hillaire-Buys, Dominique and Le Quellec, Alain and Hansel, Sylvie},
	month = jan,
	year = {2003},
	pmid = {12503925},
	keywords = {Adult, Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Drug Hypersensitivity, Drug-Related Side Effects and Adverse Reactions, Female, Hospitalization, Humans, Length of Stay, Male, Medication Errors, Middle Aged, Pharmacy Service, Hospital, Prospective Studies, Risk Factors},
	pages = {5--11}
}

Website  abstract   bibtex   

@article{
 title = {Do children of long-lived parents age more successfully?},
 type = {article},
 year = {2002},
 identifiers = {[object Object]},
 keywords = {Age Distribution,Aged,Aged, 80 and over,Aging/*genetics/*physiology,Cognition/physiology,Cross-Sectional Studies,Denmark/epidemiology,Female,Genetics, Population,Hand Strength/physiology,Health Status,Humans,Interviews,Male,Middle Aged,Nuclear Family,Odds Ratio,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.},
 pages = {334-339},
 volume = {13},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11964936},
 id = {d2c3d7a4-58f6-3e99-95c4-c6ccb4863013},
 created = {2017-06-19T13:42:11.345Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:42:11.443Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1044-3983<m:linebreak/>Journal Article<m:linebreak/>Meta-Analysis</m:note>},
 abstract = {BACKGROUND: Long-lived individuals are rare and may be selected in part for the genetic factors that promote successful aging. The children of long-lived parents may therefore age more successfully than the children of short-lived parents. METHODS: We used three major cross-sectional population-based surveys to study the association of parental longevity with successful aging in offspring. The measures of aging were hand-grip strength, cognitive performance (Mini Mental State Examination and a cognitive composite score), self-reported diseases, and self-rated health. RESULTS: For every additional 10 years the parents lived, their children's grip strength increased by 0.32 kg (95% CI = 0.00-0.63), Mini Mental State Examination score by 0.20 points (95% CI = 0.03-0.37), and cognitive composite score by 0.24 points (95% CI = 0.07-0.40). A 10-year increment of parental life was associated with a reduction by approximately 0.20 in the adjusted odds ratio for their children having each of the following conditions: diabetes; hypertension; ischemic heart disease; heart failure; stroke; or fair, poor, or very poor self-rated health. Almost all the effects were seen solely in the cohort of 70+-year-olds, but not among middle-aged or nonagenarian subjects. CONCLUSIONS: Parental life span is positively associated with the children's physical and cognitive functioning and avoidance of some of the common chronic diseases. However, the effects are small and are seen among offspring who are elderly, but not among the middle-aged or the oldest old.},
 bibtype = {article},
 author = {Frederiksen, H and McGue, M and Jeune, B and Gaist, D and Nybo, H and Skytthe, A and Vaupel, J W and Christensen, K},
 journal = {Epidemiology},
 number = {3}
}

Website  abstract   bibtex   

@article{
 title = {Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus},
 type = {article},
 year = {2001},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Aged, 80 and over,Alleles,Apolipoproteins B/*genetics,Comparative Study,DNA/analysis/genetics,Demography,Denmark,Female,Gene Frequency/genetics,Genotype,Humans,Italy,Longevity/*genetics,Male,Middle Aged,Minisatellite Repeats/*genetics,Models, Genetic,Polymerase Chain Reaction,Research Support, Non-U.S. Gov't,Risk,Sex Characteristics},
 pages = {371-376},
 volume = {65},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11592926},
 id = {30365bd9-8031-3f7e-8ef2-9d02c1ab8dba},
 created = {2017-06-19T13:45:42.031Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:45:42.142Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0003-4800<m:linebreak/>Journal Article</m:note>},
 abstract = {In Danes we replicated the 3'APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.},
 bibtype = {article},
 author = {Varcasia, O and Garasto, S and Rizza, T and Andersen-Ranberg, K and Jeune, B and Bathum, L and Andreev, K and Tan, Q and Yashin, A I and Bonafe, M and Franceschi, C and De Benedictis, G},
 journal = {Ann Hum Genet},
 number = {Pt 4}
}

@article{bartolomeoLaterallyDirectedArm2001,
	title = {Laterally directed arm movements and right unilateral neglect after left hemisphere damage},
	volume = {39},
	issn = {00283932},
	doi = {10/cn877m},
	abstract = {Signs of unilateral neglect for events occurring in one hemispace most often result from right hemisphere lesions. Right unilateral neglect after left hemisphere damage is much rarer, and has received less attention. The present study explores the relationships between right unilateral neglect and asymmetries in producing laterally directed arm movements in the horizontal plane in left brain-damaged (LBD) patients. Participants produced right- or left-directed arm movements with their left arm in response to centrally located visual stimuli. Results showed that LBD patients with signs of right unilateral neglect were consistently slowed when producing arm movements toward the right (neglected) side, as compared to left-directed movements. Taking into account patients with and without signs of neglect, this directional asymmetry positively correlated with a reaction-time measure of perceptual spatial bias. These findings stand in contrast with previous results obtained with the same experimental paradigm in right brain-damaged patients, in whom a consistent slowing of leftward-directed movements was rare and apparently unrelated to the presence and severity of left neglect. These conflicting results are discussed with respect to the hypothesis that different mechanisms may underlie left and right unilateral neglect.},
	number = {10},
	journal = {Neuropsychologia},
	author = {Bartolomeo, P and Chokron, S and Gainotti, G},
	year = {2001},
	keywords = {Adult, Female, Humans, Male, Aged, Orientation, Middle Aged, Aged, 80 and over, Brain Mapping, Neuropsychological Tests, Perceptual Disorders, Psychomotor Performance, Cerebral Cortex, Cerebral Infarction, Dominance, Cerebral, Hemianopsia, Cerebral Hemorrhage, \#nosource},
	pages = {1013--21},
	file = {Bartolomeo et al_2001_Laterally directed arm movements and right unilateral neglect after left.pdf:/Users/paolobartolomeo/PICNIC Lab Dropbox/Paolo Bartolomeo/zotero/pdf/pdf/Bartolomeo et al_2001_Laterally directed arm movements and right unilateral neglect after left.pdf:application/pdf},
}

Paper  abstract   bibtex   

@article{
 title = {The local field in infratentorial ependymoma: does the entire posterior fossa need to be treated?},
 type = {article},
 year = {2001},
 identifiers = {[object Object]},
 keywords = {80 and over,Adolescent,Adult,Aged,Child,Cranial Fossa,Ependymoma,Ependymoma: radiotherapy,Ependymoma: surgery,Female,Humans,Infratentorial Neoplasms,Infratentorial Neoplasms: radiotherapy,Infratentorial Neoplasms: surgery,Male,Middle Aged,Posterior,Preschool,Radiotherapy Dosage,Survival Analysis,Treatment Failure},
 pages = {757-61},
 volume = {49},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11172959},
 month = {3},
 day = {1},
 id = {824b4da9-3acc-37d7-9dd5-8c30fb640a36},
 created = {2014-08-02T21:56:13.000Z},
 file_attached = {true},
 profile_id = {be299c88-7105-3a8d-a1cd-3aa95c25e2c4},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-12-29T19:36:51.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {INTRODUCTION: In the past decade, there have been multiple reports indicating that the predominant problem in the curative treatment of intracranial ependymoma is local failure. As a result, many have recommended local field radiotherapy. For infratentorial ependymoma, there is controversy regarding what constitutes the local field. Some radiation oncologists advocate coverage of the entire posterior fossa, whereas others recommend radiotherapy to the tumor bed and a safety margin. METHODS AND MATERIALS: From 1984 to 1998, 28 patients with posterior fossa ependymoma were diagnosed at our institution. There were 18 males and 10 females with a median age of 12 years (range, 2-81 years). Four patients (14%) had high-grade ependymoma and 3 (11%) had M+ disease at initial diagnosis. Gross total resection was achieved in 17 (61%) and postoperative radiotherapy (RT) was given to 22 (77%). Radiotherapy fields were craniospinal in 10, whole brain in 1, posterior fossa in 2, and tumor bed with a 2-cm. margin in 9. Median dose to the primary site was 54 Gy (range, 45-55 Gy). All 4 patients with high-grade ependymoma received craniospinal RT. Six patients did not receive RT after surgery. Magnetic resonance imaging (MRI) or computed tomography (CT) scans of the brain at initial diagnosis were compared to MRI or CT scans of patients at relapse to determine if the local relapse was in the tumor bed or nontumor bed posterior fossa. Median follow-up was 127 months (range, 14-188 months). RESULTS: Six patients have relapsed. For the 11 patients who had craniospinal or whole brain radiotherapy (RT), 3 recurred (tumor bed 1, spine 1, nontumor bed posterior fossa + spine 1). Both patients who failed in the spine had high-grade tumors. Neither of the 2 treated with posterior fossa fields relapsed. For the 9 patients who had tumor bed RT alone and the 6 who did not receive RT, there were 3 relapses; all were in the tumor bed. There were no relapses in the nontumor bed posterior fossa. CONCLUSION: For nondisseminated, low-grade infratentorial ependymoma, the radiotherapy volume does not need to include the entire posterior fossa. This information can be used to minimize late effects of RT in the era of three-dimensional (conformal) radiotherapy. No conclusion can be reached regarding the appropriate local field for high-grade infratentorial ependymoma because of the small number of patients.},
 bibtype = {article},
 author = {Paulino, A C},
 journal = {International Journal of Radiation Oncology Biology Physics},
 number = {3}
}

@article{
 title = {Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast and/or ovarian cancer families from North-Eastern Poland},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {*Founder Effect,Adult,Aged,Aged, 80 and over,BRCA1 Protein/*genetics,BRCA2 Protein,Breast Neoplasms/*genetics,Female,Genetic Markers/genetics,Germ-Line Mutation/*genetics,Human,Male,Middle Age,Neoplasm Proteins/*genetics,Ovarian Neoplasms/*genetics,Poland,Support, Non-U.S. Gov't,Support, U.S. Gov't, P.H.S.,Transcription Factors/*genetics},
 pages = {480-1.},
 volume = {15},
 id = {fffeb98c-4cdd-3ed3-a41a-4a351d41efdd},
 created = {2017-06-19T13:44:22.272Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:22.379Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>},
 abstract = {Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact of BRCA2 mutations in Poland, we have analyzed 25 high-risk breast and/or ovarian cancer families from North-Eastern Poland for mutations in all coding exons of the BRCA1 and BRCA2 genes, using combined heteroduplex analysis/SSCP followed by direct DNA sequence analysis. Out of 25 probands a total of five (20%) carried three recurrent BRCA1 mutations (300T>G, 3819del5, 5382insC). The 300T>G mutation accounted for 60% (3/5) of BRCA1 mutations and allelotyping suggested a common founder of this mutation. No unique mutations were found. In addition, we identified three BRCA2 (12%) mutations, one recurrent 4075delGT, and two novel frameshift mutations, 7327ins/dupl19 and 9068delA. We conclude that 30% of high-risk families from North-Eastern Poland may be due to recurrent BRCA1 and unique BRCA2 mutations. Intriguingly, the BRCA1 mutation spectrum seems to be different within subregions of Poland.},
 bibtype = {article},
 author = {van Der Looij, M and Wysocka, B and Brozek, I and Jassem, J and Limon, J and Olah, E},
 journal = {Hum Mutat},
 number = {5}
}

@article{behrmann_attention_1999,
	title = {Attention accesses multiple reference frames: evidence from visual neglect},
	volume = {25},
	abstract = {Research with normal participants has demonstrated that mechanisms of selective attention can simultaneously gain access to internal representations of spatial information defined with respect to both location- and object-based frames of reference. The present study demonstrates that patients with unilateral spatial neglect following a right-hemisphere lesion are poorer at detecting information on the contralateral left side in both location- and object-based spatial coordinates simultaneously. Moreover, the extent of the neglect is modulated by the probability of a target's appearing in either reference frame; as the probability of sampling a target in a particular frame of reference increases, so does the severity of neglect in the frame. These findings suggest that attention can be flexibly and strategically assigned to a reference frame depending on the contingencies of the task.},
	number = {1},
	journal = {J Exp Psychol Hum Percept Perform},
	author = {Behrmann, M and Tipper, S P},
	year = {1999},
	pmid = {10069027},
	keywords = {*Attention, *Field Dependence-Independence, *Orientation, *Pattern Recognition, Visual, Aged, Aged, 80 and over, Brain Damage, Chronic/diagnosis, Dominance, Cerebral, Female, Hemianopsia/diagnosis, Humans, Male, Middle Aged, Neuropsychological Tests, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.},
	pages = {83--101},
}

Paper  doi  abstract   bibtex   

@article{bisiach_two-dimensional_1999,
	title = {Two-dimensional distortion of space representation in unilateral neglect: perceptual and response-related factors},
	volume = {37},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10617269},
	doi = {10.1016/S0028-3932(99)00046-9},
	abstract = {The paper reports the results of an experiment in which left-neglect patients were required to point at the location they judged vertically to correspond (within the frame of the visual stimulus display they were given) with a cue that was variably located along a left-right axis lying proximally or distally with respect to the left-right axis over which they had to give their response. Patients were found to make rightward errors as in a similar, single-case study. The significant positive correlation between those errors and the degree of response bias on a manual-response version of the Milner Landmark Task suggests that rightward pointing errors made by left-neglect patients in conditions such as those set in the present experiment are due to a dysfunction selectively affecting an output-related component of space representation.},
	number = {13},
	journal = {Neuropsychologia},
	author = {Bisiach, E. and Ricci, R. and Berruti, G. and Genero, R. and Pepi, R. and Fumelli, T.},
	year = {1999},
	keywords = {\#nosource, Aged, Aged, 80 and over, Cerebral Cortex/physiopathology, Cerebrovascular Accident/diagnosis/physiopathology, Dominance, Cerebral/*physiology, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Orientation/*physiology, Perceptual Disorders/diagnosis/*physiopathology, Perceptual Distortion/*physiology, Psychomotor Performance/*physiology, Reference Values, Research Support, Non-U.S. Gov't},
	pages = {1491--8},
}

@article{murphy_audit_1998-1,
	title = {Audit of patients on oral anticoagulants with {International} normalized ratios of eight or above},
	volume = {20},
	issn = {0141-9854},
	abstract = {We reviewed retrospectively the medical records of all patients (n = 77, mean age 74.2) on oral anticoagulants with an International normalized ratio (INR) of eight or above in a 12-month period in the Leicestershire District Health Authority (DHA). From a total of 55,625 INRs, 131 (0.24\%) were {\textbackslash}textgreater or = 8. A major cause of over-anticoagulation was unsatisfactory dose loading during in-hospital commencement of oral anticoagulation. The incidence of major bleeding was 12.9\% of total episodes of INR {\textbackslash}textgreater or = 8 with two haemorrhage-related fatalities. Therapy of major haemorrhage with fresh frozen plasma (FFP) and intravenous (i.v) vitamin K proved effective but was not given in a majority of such cases. In conclusion, improvements in initial dose loading of oral anticoagulation and in the management of major haemorrhage are required. Severely over-anticoagulated patients without obvious bleeding should nevertheless receive small dose vitamin K therapy to reduce the risk of haemorrhage related morbidity and mortality without compromising subsequent oral anti-coagulant control.},
	language = {eng},
	number = {4},
	journal = {Clinical and Laboratory Haematology},
	author = {Murphy, P. T. and Casey, M. C. and Abrams, K. R.},
	month = aug,
	year = {1998},
	pmid = {9777273},
	keywords = {80 and over, Adult, Aged, Anticoagulants, Cardiovascular Diseases, Drug Interactions, Female, Heart Failure, Hemorrhage, Humans, International Normalized Ratio, Male, Medical Audit, Middle Aged, Retrospective Studies, Thrombosis, United Kingdom},
	pages = {253--257},
}

Website  abstract   bibtex   

@article{
 title = {How heritable is individual susceptibility to death? The results of an analysis of survival data on Danish, Swedish and Finnish twins},
 type = {article},
 year = {1998},
 identifiers = {[object Object]},
 keywords = {*Death,*Genetic Predisposition to Disease,Adult,Age Factors,Aged,Aged, 80 and over,Denmark,Disease Susceptibility,Environment,Epidemiology, Molecular,Female,Finland,Forecasting,Health,Humans,Life Tables,Likelihood Functions,Longevity/genetics,Male,Middle Aged,Models, Genetic,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.,Sex Factors,Survival Analysis,Sweden,Twins/*genetics},
 pages = {196-205},
 volume = {1},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10100811},
 id = {161c25f0-f407-3983-ac34-656acbfb7169},
 created = {2017-06-19T13:42:57.913Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:42:58.237Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1369-0523<m:linebreak/>Journal Article<m:linebreak/>Twin Study</m:note>},
 abstract = {Molecular epidemiological studies confirm a substantial contribution of individual genes to variability in susceptibility to disease and death for humans. To evaluate the contribution of all genes to susceptibility and to estimate individual survival characteristics, survival data on related individuals (eg twins or other relatives) are needed. Correlated gamma-frailty models of bivariate survival are used in a joint analysis of survival data on more than 31,000 pairs of Danish, Swedish and Finnish male and female twins using the maximum likelihood method. Additive decomposition of frailty into genetic and environmental components is used to estimate heritability in frailty. The estimate of the standard deviation of frailty from the pooled data is about 1.5. The hypothesis that variance in frailty and correlations of frailty for twins are similar in the data from all three countries is accepted. The estimate of narrow-sense heritability in frailty is about 0.5. The age trajectories of individual hazards are evaluated for all three populations of twins and both sexes. The results of our analysis confirm the presence of genetic influences on individual frailty and longevity. They also suggest that the mechanism of these genetic influences may be similar for the three Scandinavian countries. Furthermore, results indicate that the increase in individual hazard with age is more rapid than predicted by traditional demographic life tables.},
 bibtype = {article},
 author = {Iachine, I A and Holm, N V and Harris, J R and Begun, A Z and Iachina, M K and Laitinen, M and Kaprio, J and Yashin, A I},
 journal = {Twin Res},
 number = {4}
}

Website  abstract   bibtex   

@article{
 title = {Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group},
 type = {article},
 year = {1996},
 identifiers = {[object Object]},
 keywords = {Adolescent,Adult,Age Distribution,Aged,Aged, 80 and over,Allergens/diagnostic use,Asthma/epidemiology/*genetics,Atlantic Ocean,Bronchoconstrictor Agents/diagnostic use,Child,Child, Preschool,Consanguinity,Female,Forced Expiratory Volume,Founder Effect,Humans,Linkage (Genetics),Male,Methacholine Chloride/diagnostic use,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Sex Distribution,Skin Tests},
 pages = {1902-1906},
 volume = {153},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8665053},
 id = {ba377ad3-36ac-3937-b8d3-44f6b08c99e3},
 created = {2017-06-19T13:44:45.103Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:45.287Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1073-449x<m:linebreak/>Journal Article</m:note>},
 abstract = {Although asthma has a significant heritable component, the mode of inheritance remains controversial because of the complexity of the disease and the influence of environmental factors. Isolated, inbred populations serve to reduce variability, thus increasing the probability of gene localization. We studied the inbred population of the remote island of Tristan da Cunha to document asthma prevalence for the purpose of genetic linkage analysis. Medical histories and skin atopy were determined on 282 islanders, representing 97% of the population, and airway responsiveness was measured in 254; 226 by methacholine challenge (tidal breathing method) and 28 by bronchodilator response (400 micrograms salbutamol aerosol). Blood samples were collected from 275 islanders. Participants ranged in age from 3 to 94 yr. Asthma was defined as increased airway responsiveness (AR+: PC20 < 4 mg/ml or > or = 15% increase in FEV1 postbronchodilator) combined with a positive history (Hx+). Fifty-seven percent of the islanders had at least partial evidence of asthma (Hx+ and/or AR+) and 23% had a definitive diagnosis of asthma (AR+ with Hx+). Overall 47% of the population were atopic, atopy was proportionally higher in asthmatics (74%) than nonasthmatics (32%; p < 0.01). Analysis of the methacholine dose-response curves demonstrated that asthmatics were significantly (p < 0.01) more responsive than those with AR+ only, and nonasthmatics (AR-, Hx-) were more responsive than laboratory control subjects (p < 0.05), suggesting that these islanders may also carry an airway hyperresponsiveness gene. A frequency plot of the percent fall in FEV1 for all Hx- subjects compared with control data suggests a bimodal distribution consistent with a major gene mechanism for airway responsiveness. Genealogy mapping revealed that the islanders are direct descendants of the 15 original settlers, and historical records suggest at least two founders may have been asthmatic. The data confirm previous reports of a high asthma prevalence on Tristan and support the postulate that this prevalence is a result of gene enrichment occurring in isolated populations by virtue of extensive inbreeding and a probable founder effect.},
 bibtype = {article},
 author = {Zamel, N and McClean, P A and Sandell, P R and Siminovitch, K A and Slutsky, A S},
 journal = {Am J Respir Crit Care Med},
 number = {6 Pt 1}
}

Paper  abstract   bibtex   

@article{falconer_acute-phase_1995,
	title = {Acute-phase protein response and survival duration of patients with pancreatic cancer},
	volume = {75},
	issn = {0008-543X},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/7535184},
	abstract = {BACKGROUND

Current methods to predict survival duration of patients with pancreatic cancer are limited. The aim of this study was to determine whether certain nutritional indices and the acute-phase protein response are prognostic factors independent of disease stage for patients with unresectable pancreatic cancer.


METHODS

Variables at the time of diagnosis of 102 patients with unresectable pancreatic cancer were entered into a Cox's proportional hazards model. Included in the analysis were the serum concentration of C-reactive protein (CRP) and albumin, the extent of weight loss, age, sex, and disease stage (International Union Against Cancer criteria).


RESULTS

A multivariate analysis in which each factor was adjusted for the influence of the other factors revealed the patient age, disease stage, serum albumin, and serum CRP to be independent predictors of survival. The presence of an acute-phase protein response was the most significant independent predictors of survival duration. The median survival of those with an acute-phase protein response (CRP {\textgreater} 10 mg/L, n = 45) was 66 days compared with 222 days for those with no acute-phase protein response (n = 57, P = 0.001, Mann-Whitney U test).


CONCLUSION

The acute-phase protein response is a useful prognostic indicator for patients with unresectable pancreatic cancer. Moreover, the metabolic disturbances associated with an acute-phase protein response of patients with pancreatic cancer may be a worthwhile therapeutic target.},
	number = {8},
	urldate = {2012-03-25},
	journal = {Cancer},
	author = {Falconer, J S and Fearon, K C and Ross, J A and Elton, R and Wigmore, S J and Garden, O J and Carter, D C},
	month = apr,
	year = {1995},
	pmid = {7535184},
	keywords = {Acute-Phase Proteins, Adult, Aged, Aged, 80 and over, C-Reactive Protein, Cachexia, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Prognosis, Survival Analysis},
	pages = {2077--2082},
}

Paper  doi  abstract   bibtex   

@article{rao_relationship_1994,
	title = {The relationship between basal cell epithelioma and seborrheic keratosis. {A} study of 60 cases},
	volume = {20},
	copyright = {All rights reserved},
	issn = {0148-0812 (Print) 0148-0812 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/7962939},
	doi = {10.1111/j.1524-4725.1994.tb03201.x},
	abstract = {BACKGROUND: Various skin tumors can be seen rarely in association with seborrheic keratosis. We present 60 cases of seborrheic keratosis related to a basal cell epithelioma in the same specimen. OBJECTIVE: To report association of basal cell epithelioma with seborrheic keratosis and discuss the possibility of malignant change in seborrheic keratosis. METHODS: Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques. RESULTS: Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60). CONCLUSION: Malignant change in seborrheic keratosis is controversial. We recommend the histological evaluation of seborrheic keratosis especially when inflamed or atypical in appearance. This should not be taken as a mandate for pathological evaluation or for treatment of every seborrheic keratosis as though it was potentially malignant.},
	number = {11},
	journal = {J Dermatol Surg Oncol},
	author = {Rao, B. K. and Freeman, R. G. and Poulos, E. G. and Arbesfeld, L. and Rendon, M.},
	month = nov,
	year = {1994},
	keywords = {Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell/*complications/pathology, Cell Transformation, Neoplastic, Female, Humans, Keratosis, Seborrheic/*complications/pathology, Male, Middle Aged, Skin Neoplasms/*complications/pathology},
	pages = {761--4},
}

Paper  doi  abstract   bibtex   

@article{clayman_serum_1993,
	title = {Serum and acute phase protein modulation of the effector phase of lymphokine-activated killer cells},
	volume = {103},
	issn = {0023-852X},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/7680086},
	doi = {10.1288/00005537-199303000-00010},
	abstract = {An understanding of the role that immunomodulatory factors play in the effector phase of lymphokine-activated killer (LAK) activity is essential for the development of biologic response modifiers for use in the treatment of advanced carcinoma. Fifteen head and neck cancer patients were studied. Single-donor killer cells activated by recombinant interleukin-2 (10 U/mL) and induced in either a complete medium or complete medium plus a 10\% autologous serum solution were used. Effector phase solutions of 25\% autologous serum were used in chromium 51 release assays to determine sera immunomodulation of LAK cell cytotoxicity. Both K562 and squamous carcinoma (MDA686-Ln) tumor cell lines were tested. Significant effector phase inhibition (EPI) of cytotoxicity occurred in 40\% of studied patients. Seventy percent of patients with stage III or IV or recurrent disease exhibited EPI, whereas only 20\% of patients with stage I or II disease and 30\% of controls did so. EPI of cancer patient serum correlated directly with alpha 1-antitrypsin, alpha 1-acid glycoprotein, and C-reactive protein (CRP) levels (MDA686-Ln targets) (r = 0.6, 0.7, and 0.6, respectively) (P {\textless} .02). Neither EPI against K562 targets nor EPI in control patients correlated with acute phase protein levels. These findings suggest that advances in in vivo immunomodulatory therapy will be dependent upon further elucidation of serologic inhibition of the effector phase of the LAK cell phenomenon. The relationship between LAK cell recognition and EPI requires further investigation.},
	number = {3},
	urldate = {2012-03-25},
	journal = {The Laryngoscope},
	author = {Clayman, G L and Taylor, D L and Liu, F J and Lavedan, P and Savage, H E and Schantz, S P},
	month = mar,
	year = {1993},
	pmid = {7680086},
	keywords = {Acute-Phase Proteins, Adult, Aged, Aged, 80 and over, Antigen-Antibody Complex, Blood Proteins, C-Reactive Protein, Carcinoma, Squamous Cell, Complement C1q, Culture Media, Cytotoxicity, Immunologic, Female, Fibrinogen, Head and Neck Neoplasms, Humans, Immunologic Factors, Killer Cells, Lymphokine-Activated, Killer Cells, Natural, Lymphocyte Activation, Male, Middle Aged, Neoplasm Recurrence, Local, Orosomucoid, Tumor Cells, Cultured, alpha 1-Antitrypsin},
	pages = {299--307},
}

@article{franklin_sex_2009,
	title = {Sex differences in the association between body mass index and total hip or knee joint replacement resulting from osteoarthritis},
	volume = {68},
	issn = {1468-2060},
	doi = {10.1136/ard.2007.086868},
	abstract = {{OBJECTIVE}: To examine the association between body mass index ({BMI}) and osteoarthritis ({OA}) leading to total hip ({THR}) or knee ({TKR}) joint replacement.
{METHODS}: Case-control study design. All patients still living in Iceland who had had a {THR} or {TKR} resulting from {OA} before the end of 2002 were invited to participate. First-degree relatives of participating patients served as controls. A total of 1473 patients (872 women) and 1103 controls (599 women), all born between 1910 and 1939 and who had answered a questionnaire including questions about height and weight, were analysed. A randomly selected sample, representative of the Icelandic population, was used as a secondary control group.
{RESULTS}: The {OR}, adjusted for age, occupation and presence of hand {OA}, for having a {THR} was 1.1 (95\% {CI} 0.9 to 1.5) for overweight men and 1.7 (95\% {CI} 1.0 to 2.9) for obese men. The {OR} for having a {TKR} was 1.7 (95\% {CI} 1.1 to 2.6) for overweight men and 5.3 (95\% {CI} 2.8 to 10.1) for obese men. The {OR} for having a {THR} was 1.0 (95\% {CI} 0.8 to 1.3) for overweight women and 1.0 (95\% {CI} 0.6 to 1.5) for obese women. The {OR} for having a {TKR} was 1.6 (95\% {CI} 1.1 to 2.2) for overweight women and 4.0 (95\% {CI} 2.6 to 6.1) for obese women.
{CONCLUSION}: This study supports a positive association between high {BMI} and {TKR} in both sexes, but for {THR} the association with {BMI} seems to be weaker, and possibly negligible for women.},
	pages = {536--540},
	number = {4},
	journaltitle = {Annals of the Rheumatic Diseases},
	shortjournal = {Ann. Rheum. Dis.},
	author = {Franklin, J. and Ingvarsson, T. and Englund, M. and Lohmander, L. S.},
	date = {2009-04},
	pmid = {18504290},
	keywords = {Aged, 80 and over, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Body Mass Index, Case-Control Studies, Family, Female, Humans, Iceland, Male, Obesity, Occupational Diseases, Odds Ratio, Osteoarthritis, Hip, Osteoarthritis, Knee, Overweight, Regression Analysis, Risk Assessment, Sex Factors}
}

@article{joud_low_2012,
	title = {Low back pain: epidemiology of consultations.},
	volume = {64},
	rights = {Copyright (c) 2012 by the American College of Rheumatology.},
	issn = {2151-4658 2151-464X},
	doi = {10.1002/acr.21642},
	abstract = {{OBJECTIVE}: Low back pain ({LBP}) affects most people at some stage in life. However, the burden on the health care system is unclear. We studied: 1) the},
	pages = {1084--1088},
	number = {7},
	journaltitle = {Arthritis care \& research},
	shortjournal = {Arthritis Care Res (Hoboken)},
	author = {Joud, Anna and Petersson, Ingemar F. and Englund, Martin},
	date = {2012-07},
	pmid = {22337573},
	keywords = {Adult, Aged, Aged, 80 and over, Delivery of Health Care/utilization, Female, Humans, Low Back Pain/*diagnosis/*epidemiology, Male, Middle Aged, Prevalence, Referral and Consultation/*statistics \& numerical data, Registries, Retrospective Studies, Sweden/epidemiology}
}